Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Deborah G. Conrady"'
Autor:
Seyed Mohammad Ghafoori, Gayle F. Petersen, Deborah G. Conrady, Brandy M. Calhoun, Matthew Z. Z. Stigliano, Ruth O. Baydo, Rena Grice, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Jade K. Forwood
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Influenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to the healthcare system in the billions of dollars. Several influenza pandemics have occurred during the last century and estimated to have c
Externí odkaz:
https://doaj.org/article/76d2ef5b49eb4543ad2cf4338202406a
Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans
Autor:
Jaysón Davidson, Kyndall Nicholas, Jeremy Young, Deborah G. Conrady, Stephen Mayclin, Sandhya Subramanian, Bart L. Staker, Peter J. Myler, Oluwatoyin A. Asojo
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The high-resolution structure of a putative short-chain reductase from the commercially important bacterium Paraburkholderia xenovorans is reported. P. xenovorans degrades organic wastes such as polychlorinated biphenyls.
Paraburkholderia xenovo
Paraburkholderia xenovo
Autor:
Ryan Choi, Peter S. Horanyi, David M. Dranow, Zhongsheng Zhang, Thomas E. Edwards, Kayode K. Ojo, Donald D. Lorimer, Peter J. Myler, Kevin Hybiske, Wesley C. Van Voorhis, Logan Tillery, Edelmar D. Navaluna, Sandhya Subramanian, Bart Staker, Samantha A. Michaels, Lynn K. Barrett, Shareef Shaheen, Olusegun O. Soge, Justin K. Craig, Kayleigh F. Barrett, Jan Abendroth, Isabelle Q. Phan, Erkang Fan, Deborah G. Conrady
Publikováno v:
Protein Sci
Neisseria gonorrhoeae (Ng) and Chlamydia trachomatis (Ct) are the most commonly reported sexually transmitted bacteria worldwide and usually present as co-infections. Increasing resistance of Ng to currently recommended dual therapy of azithromycin a
Autor:
Yilin Qi, Jun Kuai, Yingzhi Bi, Huadong Sun, Deborah G. Conrady, Rajiv G. Govindaraj, Graham Hone, Rajiah A. Denny, Ken Carson, Timothy Reilly, Geraldine Harriman, Fang Wang
Publikováno v:
Cancer Research. 82:598-598
E3 ligase Casitas B-Lineage Lymphoma Proto-Oncogene B (CBL-B) is a key negative modulator of T-cell receptor and co-stimulatory regulation. CBL-B inhibition lowers the threshold of antigen-specific T cell activation, even in absence of co-stimulatory
Autor:
Karen M Gallegos, Deborah G Conrady, Sayali S Karve, Thusitha S Gunasekera, Andrew B Herr, Alison A Weiss
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30368 (2012)
Immunologically distinct forms of Shiga toxin (Stx1 and Stx2) display different potencies and disease outcomes, likely due to differences in host cell binding. The glycolipid globotriaosylceramide (Gb3) has been reported to be the receptor for both t
Externí odkaz:
https://doaj.org/article/bce1d863753b4a97bfb6f6be11328253
Autor:
Deborah G Conrady, Michael J Flagler, David R Friedmann, Bradley D Vander Wielen, Rhett A Kovall, Alison A Weiss, Andrew B Herr
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15153 (2010)
Escherichia coli strain O157:H7 is a major cause of food poisoning that can result in severe diarrhea and, in some cases, renal failure. The pathogenesis of E. coli O157:H7 is in large part due to the production of Shiga toxin (Stx), an AB(5) toxin t
Externí odkaz:
https://doaj.org/article/1489be60df354a77a8c9bf5200b213af
Publikováno v:
Biochemical Journal. 474:427-443
Staphylococcus epidermidis is an opportunistic pathogen that can form robust biofilms that render the bacteria resistant to antibiotic action and immune responses. Intercellular adhesion in S. epidermidis biofilms is mediated by the cell wall-associa
Autor:
Alexander D. Barrow, Dimitri Y. Chirgadze, Michal Blaszczyk, Andrew B. Herr, Deborah G. Conrady, Richard W. Farndale, Long Zhou, Jeanette L.C. Miller, Jennifer M. Hinerman, Dominique Bihan
Publikováno v:
Blood. 127:529-537
The osteoclast-associated receptor (OSCAR) is a collagen-binding immune receptor with important roles in dendritic cell maturation and activation of inflammatory monocytes as well as in osteoclastogenesis. The crystal structure of the OSCAR ectodomai
Autor:
Alison A. Weiss, Daniel J. Hassett, Cristin C. Brescia, Katsunori Horii, Deborah G. Conrady, Andrew B. Herr
Publikováno v:
Proceedings of the National Academy of Sciences. 105:19456-19461
Hospital-acquired bacterial infections are an increasingly important cause of morbidity and mortality worldwide. Staphylococcal species are responsible for the majority of hospital-acquired infections, which are often complicated by the ability of st
Autor:
Liam J. Worrall, Yang Wang, Shawn French, Cullen L. Myers, Maya A. Farha, Natalie C. J. Strynadka, Tomasz L. Czarny, Eric Oldfield, Eric D. Brown, Deborah G. Conrady
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(35)
Drug combinations are valuable tools for studying biological systems. Although much attention has been given to synergistic interactions in revealing connections between cellular processes, antagonistic interactions can also have tremendous value in