Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Deborah Gérard"'
Autor:
Leticia Soriano-Baguet, Melanie Grusdat, Henry Kurniawan, Mohaned Benzarti, Carole Binsfeld, Anouk Ewen, Joseph Longworth, Lynn Bonetti, Luana Guerra, Davide G. Franchina, Takumi Kobayashi, Veronika Horkova, Charlène Verschueren, Sergio Helgueta, Deborah Gérard, Tushar H. More, Antonia Henne, Catherine Dostert, Sophie Farinelle, Antoine Lesur, Jean-Jacques Gérardy, Christian Jäger, Michel Mittelbronn, Lasse Sinkkonen, Karsten Hiller, Johannes Meiser, Dirk Brenner
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112153- (2023)
Summary: Pyruvate dehydrogenase (PDH) is the central enzyme connecting glycolysis and the tricarboxylic acid (TCA) cycle. The importance of PDH function in T helper 17 (Th17) cells still remains to be studied. Here, we show that PDH is essential for
Externí odkaz:
https://doaj.org/article/4c586aa5408c4295a1eead933ab65a54
Autor:
Jonas Walter, Silvia Bolognin, Suresh K. Poovathingal, Stefano Magni, Deborah Gérard, Paul M.A. Antony, Sarah L. Nickels, Luis Salamanca, Emanuel Berger, Lisa M. Smits, Kamil Grzyb, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Jochen Ohnmacht, Michele Bertacchi, Javier Jarazo, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Rejko Krüger, Thomas Sauter, Michèle Studer, Luis Pereira de Almeida, Karl J. Tronstad, Lasse Sinkkonen, Alexander Skupin, Jens C. Schwamborn
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109864- (2021)
Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a
Externí odkaz:
https://doaj.org/article/2b9fa19fd71645ae8efd92a4e547da7e
Autor:
Živa Frangež, Deborah Gérard, Zhaoyue He, Marios Gavriil, Yuniel Fernández-Marrero, S. Morteza Seyed Jafari, Robert E. Hunger, Philippe Lucarelli, Shida Yousefi, Thomas Sauter, Lasse Sinkkonen, Hans-Uwe Simon
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Autophagy is a highly conserved cellular process in which intracellular proteins and organelles are sequestered and degraded after the fusion of double-membrane vesicles known as autophagosomes with lysosomes. The process of autophagy is dependent on
Externí odkaz:
https://doaj.org/article/92f2f53d26a24de8bac3faed30cc5478
Autor:
Kamil Grzyb, Rejko Krüger, Jochen Ohnmacht, Lasse Sinkkonen, Laura Gonzalez-Cano, Tomasz Ignac, Luis Salamanca, Emanuel Berger, Karl Johan Tronstad, Lisa M. Smits, Jens Christian Schwamborn, Paul Antony, Silvia Bolognin, Alexander Skupin, Michèle Studer, Javier Jarazo, Fredrik Hoel, Thomas Sauter, Sarah Louise Nickels, Xiaobing Qing, Anna S. Monzel, Jonas Walter, Rita Perfeito, Deborah Gérard, Luís Pereira de Almeida, Stefano Magni, Michele Bertacchi, Suresh Poovathingal
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109864-(2021)
Cell reports
Cell reports
Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d0963bff88e50986d632a723edeb86
https://lirias.kuleuven.be/handle/20.500.12942/715986
https://lirias.kuleuven.be/handle/20.500.12942/715986
Autor:
Marcel H. Schulz, Florian Schmidt, Peter Ebert, Deborah Gérard, Rashi Halder, Lasse Sinkkonen, Thomas Sauter, Aurélien Ginolhac, Martine Schmitz
Publikováno v:
Nucleic Acids Research. Oxford, United Kingdom: Oxford University Press (2018).
Nucleic Acids Research
Nucleic Acids Research
Temporal data on gene expression and context-specific open chromatin states can improve identification of key transcription factors (TFs) and the gene regulatory networks (GRNs) controlling cellular differentiation. However, their integration remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc882dfda301010cb6f05776e435e7e2
https://doi.org/10.1093/nar/gky1240
https://doi.org/10.1093/nar/gky1240
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612651
Cellular energy metabolism is regulated by complex metabolic pathways. Although anaerobic glycolysis was reported as a primary source of energy in cancer leading to a high rate of lactate production, current evidence shows that the main energy source
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a967f00deb37dfc6fcda724ca201f4a
https://doi.org/10.1007/978-1-0716-1266-8_9
https://doi.org/10.1007/978-1-0716-1266-8_9
Autor:
Thomas Farge, Marc Diederich, Franck Morceau, Jean-Emmanuel Sarry, Christian Recher, Barbora Orlikova-Boyer, Mario Dicato, Marion Orsini, Anthoula Gaigneaux, Sébastien Chateauvieux, Deborah Gérard
Publikováno v:
Haematologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17166f5ee5bf57515db291d9154196de
https://europepmc.org/articles/PMC7271611/
https://europepmc.org/articles/PMC7271611/
Autor:
Aloran Mazumder, Muneer Ahamed, Hélène Losson, Byung Woo Han, Mario Dicato, Marc Diederich, Deborah Gérard, Michael Schnekenburger, Koen Vermeulen, Manon Lernoux, Guy Bormans, Jin Young Lee, Christo Christov, Hyunggu Hahn, Dong-Wook Kim
Publikováno v:
Clinical Epigenetics
Background Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce2f35012e269663eb6a6d720640b44
https://lirias.kuleuven.be/handle/123456789/656313
https://lirias.kuleuven.be/handle/123456789/656313
Autor:
Jung Weon Lee, Barbora Orlikova-Boyer, Deborah Gérard, Hye-Jin Kim, Ludmila Ermolenko, Christo Christov, Ali Al-Mourabit, Marc Diederich, Michael Schnekenburger, Mario Dicato, Seungwon Ji, Claudia Cerella, Aloran Mazumder, Heeju Ryu, Sungmi Song, Jin Young Lee, Dong-Wook Kim
Publikováno v:
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2020, 11 (2), ⟨10.1038/s41419-020-2304-8⟩
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 2, Pp 1-20 (2020)
Cell Death and Disease, Nature Publishing Group, 2020, 11 (2), ⟨10.1038/s41419-020-2304-8⟩
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 2, Pp 1-20 (2020)
By comparing imatinib-sensitive and -resistant chronic myeloid leukemia (CML) cell models, we investigated the molecular mechanisms by which tetrahydrobenzimidazole derivative TMQ0153 triggered caspase-dependent apoptosis at low concentrations accomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a33d10ad949c9ee87584a77602024a
https://hal.archives-ouvertes.fr/hal-03004649
https://hal.archives-ouvertes.fr/hal-03004649
Autor:
Deborah Gérard, Christo Christov, Mario Dicato, Marc Diederich, Anthoula Gaigneaux, Michael Schnekenburger, Cindy Grandjenette, Aloran Mazumder
Publikováno v:
Cancer letters. 469
Although tyrosine kinase inhibitors (TKIs) revolutionized the management of chronic myeloid leukemia (CML), resistance against TKIs and leukemia stem cell (LSC) persistence remain a clinical concern. Therefore, new therapeutic strategies combining co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab85bd9b7fc5760ef3d92f9e096fb68
https://pubmed.ncbi.nlm.nih.gov/31734352
https://pubmed.ncbi.nlm.nih.gov/31734352