Výsledky vyhledávání - "Deborah F. Chapman"

Metabotropic Glutamate Receptor mGlu5 Is a Mediator of Appetite and Energy Balance in Rats and Mice

Autor: Mark A. Varney, Nicholas D. P. Cosford, Jeffery J. Anderson, Una Campbell, Margaret J. Bradbury, Deborah F. Chapman, Lida R. Tehrani, Darlene R. Giracello, Christopher D. King, A. M. Strack

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 313:395-402

The metabotropic glutamate receptor subtype mGlu5 modulates central reward pathways. Many transmitter systems within reward pathways affect feeding. We examined the potential role of mGlu5 in body weight regulation using genetic and pharmacological a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52454c9bcd6cc70440ef92af9dbd726a
https://doi.org/10.1124/jpet.104.076406

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2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Autor: Jeffrey Roger Roppe, Nicholas D. P. Cosford, Lida R. Tehrani, Deborah F. Chapman, Merryl Cramer, Nicholas D. Smith, Steve F. Poon, Thomas S. Reger, Dehua Huang, Janice Chung

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:5473-5476

Structure–activity relationship studies on 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 2 led to the discovery of 2-{2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine (10)—a highly potent and selective mGlu5 receptor antagonist with good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9240feead331b5af99660bf78b37033d
https://doi.org/10.1016/j.bmcl.2004.09.012

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In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine)

Autor: Jeffery J. Anderson, Mark A. Varney, Christopher D. King, Margaret J. Bradbury, Deborah F. Chapman, Greg Holtz, Nicholas D. P. Cosford, Jeffrey R. Roppe, Darlene R. Giracello

Publikováno v: European Journal of Pharmacology. 473:35-40

In vivo receptor occupancy of mGlu5 receptor antagonists was quantified in rat and mouse brain using the mGlu5 receptor selective antagonist [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine) ([3H]methoxy-PEPy). Administration of [3H]methoxy-PEPy (50 mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be033af1806d2538cfdab7fc5078019
https://doi.org/10.1016/s0014-2999(03)01935-6

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[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization

Autor: Darlene R. Giracello, Blake A. Rowe, Nicholas D. P. Cosford, Mark A. Varney, Deborah F. Chapman, Margaret J. Bradbury, Jeffery J. Anderson, Lida R. Tehrani, Greg Holtz, Sara P. Rao

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 303:1044-1051

The binding of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (methoxymethyl-MTEP), a potent and selective antagonist for metabotropic glutamate (mGlu)5 receptors, was characterized in rat brain both in vitro and in vivo. Nonspecifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02261e288431280fa923c3e0993cf6e7
https://doi.org/10.1124/jpet.102.040618

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Comparison of TNK With Wild-Type Tissue Plasminogen Activator in a Rabbit Embolic Stroke Model

Autor: Harold Thibodeaux, Patrick D. Lyden, Deborah F. Chapman, Paul A. Lapchak, Sonia Nunez, Justin A. Zivin

Publikováno v: Scopus-Elsevier

Background and Purpose —Tissue plasminogen activator (tPA) is an effective treatment for stroke, but its utility is limited by fear of cerebral hemorrhage. Tenecteplase (TNK), a genetically modified form of wild-type tPA, exhibits a longer biologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1ef5ae672cd258cddec54953550d32
https://doi.org/10.1161/01.str.32.3.748

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Pharmacological Effects of the Spin Trap Agents N -t-Butyl-Phenylnitrone (PBN) and 2,2,6,6-Tetramethylpiperidine- N -Oxyl (TEMPO) in a Rabbit Thromboembolic Stroke Model

Autor: Paul A. Lapchak, Justin A. Zivin, Deborah F. Chapman

Publikováno v: Stroke. 32:147-153

Background and Purpose —It has been proposed that spin trap agents such as N -t-butyl-phenylnitrone (PBN) may be useful as neuroprotective agents in the treatment of ischemia and stroke. However, to date, there is little information concerning the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ffd58ca53fb3e3f7044edd1bd4d7567
https://doi.org/10.1161/01.str.32.1.147

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Dehydroepiandrosterone Sulfate Is Neuroprotective in a Reversible Spinal Cord Ischemia Model

Autor: Justin A. Zivin, Sonia Nunez, Deborah F. Chapman, Paul A. Lapchak

Publikováno v: Stroke. 31:1953-1957

Background and Purpose —Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may function as neurotrophic or neuroprotective factors to protect central nervous system (CNS) neurons against a variety of insults, including excitotoxicity. The prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6cdf18335c3d46c4c9a7cb370f660b
https://doi.org/10.1161/01.str.31.8.1953

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Relationships between Organizational Culture and Organizational Performance

Autor: Deborah F. Chapman, M. M. Petty, N. A. Beadles, David W. Connell, Christopher M. Lowery

Publikováno v: Psychological Reports. 76:483-492

Data on measures of organizational culture and organizational performance were collected at two different points in time from a sample of 12 organizations of a firm in the electric utility industry. Pearson correlations indicated measures of organiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8916cd5e73662bf117ab6b541c2cac2
https://doi.org/10.2466/pr0.1995.76.2.483

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3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

Autor: Merryl Cramer, Jeffrey Roger Roppe, Lida R. Tehrani, Nicholas D. Smith, Dehua Huang, Thomas Jon Seiders, Steve F. Poon, Deborah F. Chapman, Janice Chung, Nicholas D. P. Cosford

Publikováno v: Bioorganicmedicinal chemistry letters. 15(22)

Structure-activity relationship studies on the phenyl ring of 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 2 led to the discovery that small, non-hydrogen bond donor substituents at the 3-position led to a substantial increase in in vitro potency.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8291ecdeff7eb5a81bdbad0e0ed1ca42
https://pubmed.ncbi.nlm.nih.gov/16183275

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3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Autor: Brian W. Eastman, Nicholas D. Smith, Steve F. Poon, Janice Chung, Nicholas D. P. Cosford, Gregory Holtz, Deborah F. Chapman, Merryl Cramer

Publikováno v: Bioorganicmedicinal chemistry letters. 14(22)

Structure-activity relationship studies performed around 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile for the purpose of developing novel mGlu5 receptor antagonists are described. Synthesis of a series of four-ring tetrazoles led to the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b95f592138de119b9c7b205dd4257ee
https://pubmed.ncbi.nlm.nih.gov/15482907

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