Výsledky vyhledávání - "Deborah E. Banker"

PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism

Autor: Sasha J. Mayer, Roland B. Walter, Frederick R. Appelbaum, Jason L. Pirga, Deborah E. Banker, Michelle R. Cronk

Publikováno v: Blood. 106:3584-3593

Background: Multidrug resistance (MDR) is frequently associated with expression of anti-apoptotic proteins of the Bcl-2 family and/or ATP-binding cassette (ABC) transporter proteins. We previously showed that the peripheral benzodiazepine receptor (p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b9fa2995f75931ad9ff4f4b62926fb
https://doi.org/10.1182/blood-2005-02-0711

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Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells

Autor: Frederick R. Appelbaum, Cheryl L. Willman, Richard A. Zager, Henry Y. Li, Deborah E. Banker, Sasha J. Mayer

Publikováno v: Blood. 104:1816-1824

Cholesterol levels are abnormally increased in many acute myeloid leukemia (AML) samples exposed in vitro to chemotherapy. Blocking these acute cholesterol responses selectively sensitizes AML cells to therapeutics. Thus, defining the molecular mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30155f8f7612b0980e723a8b7011a8ec
https://doi.org/10.1182/blood-2004-01-0395

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The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin

Autor: Brian W. Raden, Michelle R. Cronk, Irwin D. Bernstein, Frederick R. Appelbaum, Deborah E. Banker, Roland B. Walter

Publikováno v: Blood. 103:4276-4284

The antibody-targeted therapeutic, gemtuzumab ozogamicin (GO, Mylotarg), is approved for treatment of relapsed acute myeloid leukemia (AML). We previously showed that AML blasts from GO refractory patients frequently express the drug transporters P-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2a68a2fc0dfa494552cdd11b8c81b4
https://doi.org/10.1182/blood-2003-11-3825

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Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses

Autor: Cheryl L. Willman, Frederick R. Appelbaum, Henry Y. Li, Richard A. Zager, Deborah E. Banker

Publikováno v: Blood. 101:3628-3634

The mevalonate pathway produces many critical substances in cells, including sterols essential for membrane structure and isoprenoids vital to the function of many membrane proteins. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc85eda49feb196afa89b6c3bfdc68f2
https://doi.org/10.1182/blood-2002-07-2283

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Acute myeloid leukemia cells are protected from spontaneous and drug-induced apoptosis by direct contact with a human bone marrow stromal cell line (HS-5)

Autor: Deborah E. Banker, Sara M Garrido, Cheryl L. Willman, Frederick R. Appelbaum

Publikováno v: Experimental Hematology. 29:448-457

In vitro culture systems that parallel in vivo growth conditions are needed to study leukemia biology and to accurately test therapeutic efficacies. We investigated the effects of the HS-5 human bone marrow stromal cell line on cultured primary leuke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917d102d0608f3f2a8a1cc8f60035233
https://doi.org/10.1016/s0301-472x(01)00612-9

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Blasts from elderly acute myeloid leukemia patients are characterized by low levels of culture- and drug-induced apoptosis

Autor: John J Cooper, Cheryl L Willman, Frederick R. Appelbaum, Sara M. Garrido, Deborah E. Banker, Kenneth J. Kopecky

Publikováno v: Leukemia Research. 25:23-32

Increasing evidence suggests that the biology of acute myeloid leukemia (AML) may differ between older and younger patients, with a higher incidence of antecedent myelodysplasia, unfavorable cytogenetic abnormalities, and multidrug resistance seen in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92471e9833f2b72786dd63062999e420
https://doi.org/10.1016/s0145-2126(00)00083-7

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Three-color versus four-color multiparameter cell cycle analyses of primary acute myeloid leukemia samples

Autor: Sara M. Garrido, Deborah E. Banker, Cheryl L. Willman, Frederick R. Appelbaum

Publikováno v: Cytometry. 42:83-94

Checkpoint alterations that impact cell cycle and apoptosis responses to therapeutic treatments may produce drug resistance in acute myeloid leukemia (AML). To study these, we have developed flow cytometry assays of checkpoint function that also allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad2425ede504e8cc76e7e202c843d3e2
https://doi.org/10.1002/(sici)1097-0320(20000415)42:2<83::aid-cyto1>3.0.co

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Measurement of Spontaneous and Therapeutic Agent-Induced Apoptosis With BCL-2 Protein Expression in Acute Myeloid Leukemia

Autor: Deborah E. Banker, Frederick R. Appelbaum, Tom Norwood, Mark Groudine

Publikováno v: Blood. 89:243-255

We have designed in vitro assays to investigate the possible association between apoptosis and chemotherapeutic sensitivity in acute myeloid leukemias (AMLs). Consistent low levels of spontaneous apoptosis were observed in myeloid cells from normal b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd25409d2b4c977a8f43b0fdf6be005
https://doi.org/10.1182/blood.v89.1.243.243_243_255

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