Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Deborah Drage"'
Autor:
Stephen J. Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Göttgens, John C. Marioni, Jennifer Nichols, Wolf Reik
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic con
Externí odkaz:
https://doaj.org/article/b2195c14571047cdb9fd7debc8032fd3
Autor:
Ricard Argelaguet, Tim Lohoff, Jingyu Gavin Li, Asif Nakhuda, Deborah Drage, Felix Krueger, Lars Velten, Stephen J. Clark, Wolf Reik
Following gastrulation, the three primary germ layers develop into the major organs in a process known as organogenesis. Single-cell RNA sequencing has enabled the profiling of the gene expression dynamics of these cell fate decisions, yet a comprehe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22704f2c8c357894e878aa0e0971a796
https://doi.org/10.1101/2022.06.15.496239
https://doi.org/10.1101/2022.06.15.496239
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Zygotic genome activation (ZGA) represents the initiation of transcription following fertilisation. Despite its importance, we know little of the molecular events that initiate mammalian ZGA in vivo. Recent in vitro studies in mouse embryonic stem ce
Zygotic Genome Activation (ZGA) represents the initiation of transcription following fertilisation. Despite its importance in shifting developmental control from primarily maternal stores in the oocyte to the embryo proper, we know little of the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e96d9dd7b26d5580ec57c039c4a7e8c
https://doi.org/10.1101/2021.09.13.460183
https://doi.org/10.1101/2021.09.13.460183
Autor:
Côme Ialy-Radio, Julie Cocquet, Giuseppe Silvestri, Deborah Drage, Claudia Cattoni Rathje, Peter J.I. Ellis, Emma Elizabeth Philippa Johnson, Christina Patinioti, Benjamin M. Skinner, Nabeel A. Affara
Publikováno v:
Current Biology
Current Biology-CB
Current Biology-CB, 2019, 29 (21), pp.3692-3698.e4. ⟨10.1016/j.cub.2019.09.031⟩
Current Biology-CB
Current Biology-CB, 2019, 29 (21), pp.3692-3698.e4. ⟨10.1016/j.cub.2019.09.031⟩
Summary The mouse sex chromosomes exhibit an extraordinary level of copy number amplification of postmeiotically expressed genes [1, 2], driven by an “arms race” (genomic conflict) between the X and Y chromosomes over the control of offspring sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5f6e917e95462f7bd14084749c6c2d
https://kar.kent.ac.uk/75684/11/PIIS0960982219311935.pdf
https://kar.kent.ac.uk/75684/11/PIIS0960982219311935.pdf
Publikováno v:
Development. 135:2511-2520
To investigate the link between Cdx protein concentration and axial patterning in embryos, we made lines of mice OE1, OE2 and OE4 that overexpress each of the Cdx genes Cdx1, Cdx2 and Cdx4,respectively. The lines carry Cdx transgenes under the transc
Publikováno v:
The International Journal of Developmental Biology. 48:613-622
Expression of a Hoxa-7/lacZ reporter construct in transgenic mouse embryos is shifted anteriorly when the upstream enhancer is multimerized. The shift occurs in spinal ganglia, neurectoderm and in both paraxial and lateral plate mesoderms. Much of th
Publikováno v:
Mechanisms of Development. 120:573-586
The vertebrate caudal proteins, being upstream regulators of the Hox genes, play a role in establishment of the body plan. We describe analysis of two orthologous caudal genes (chick cdx-A and mouse cdx-1) by use of lacZ reporters expressed in transg
Publikováno v:
The International journal of developmental biology. 49(8)
Expression of the mouse caudal genes cdx4 and cdx2 is examined by use of lacZ reporter constructs expressed in transgenic mouse embryos. During early gastrulation, up to at least 8.5 days of development, reporter mRNA distributions are apparently sim