Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Deborah D. Giera"'
Autor:
Eric S. Nisenbaum, Darryle D. Schoepp, Gerard J. Marek, David L. McKinzie, James A. Monn, Ann E. Kingston, M. Herin, John T. Catlow, Bryan G. Johnson, Jennifer L. Burkey, Deborah D. Giera, Linda M. Rorick-Kehn, Rebecca A. Wright, David O. Calligaro
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:308-317
Group II metabotropic glutamate (mGlu) receptor agonists, including (1 S ,2 S ,5 R ,6 S )-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and (–)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), have demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d401ae47d0c219201523f1eea271445
https://doi.org/10.1124/jpet.106.110809
https://doi.org/10.1124/jpet.106.110809
Autor:
Sherri L. Andis, Steven S. Henry, Darryle D. Schoepp, Deborah D. Giera, Rebecca A. Wright, and Ann E. Kingston, Marc Herin, Gregory A. Stephenson, Bryan G. Johnson, Steven Marc Massey, John T. Catlow, Mark G. Bures, Matthew John Valli, James A. Monn
Publikováno v:
Journal of Medicinal Chemistry. 50:233-240
(-)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate (LY389795, (-)-3) is a highly potent and selective agonist of metabotropic glutamate receptors 2 (mGlu2) and 3 (mGlu3). As part of our ongoing research program, we have prepared S-oxidized var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ee56b6f2c7ef0b15c22370c0370c5a
https://doi.org/10.1021/jm060917u
https://doi.org/10.1021/jm060917u
Autor:
and Lea M. Johnson, Bryan D. Anderson, Paul Lee, Miriam del Prado, C. Richard NevillJr., Sehila Pleite, Yong Wang, † Jaime Blanco-Urgoiti, Luisa M. Martín Cabrejas, Jeremy Schulenburg York, Robert M. Campbell, Deborah D. Giera, Michal Vieth, Jeffrey A. Wolos, Denis J. McCann, Chuan Shih, Li C. Li, Beatriz López de Uralde, Nicholas A. Magnus, Concepción Sánchez, Rosanne Bonjouklian, Richard M. Schultz, María José Lorite, Alfonso De Dios
Publikováno v:
Journal of Medicinal Chemistry. 48:2270-2273
We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had low-nanomolar activity in both ATP competitive enzyme binding and inhibition of TNFalpha release in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c105a28691f426c1b73e9b9ed314fcb
https://doi.org/10.1021/jm048978k
https://doi.org/10.1021/jm048978k
Publikováno v:
Toxicological Sciences. 16:348-355
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15781bc7d434a696975f841b49154065
https://doi.org/10.1093/toxsci/16.2.348
https://doi.org/10.1093/toxsci/16.2.348
Autor:
Linda M, Rorick-Kehn, Bryan G, Johnson, Jennifer L, Burkey, Rebecca A, Wright, David O, Calligaro, Gerard J, Marek, Eric S, Nisenbaum, John T, Catlow, Ann E, Kingston, Deborah D, Giera, Marc F, Herin, James A, Monn, David L, McKinzie, Darryle D, Schoepp
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 321(1)
Group II metabotropic glutamate (mGlu) receptor agonists, including (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), have demonstrated efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41f7c69cf3ff2eb81259e83f8a98b823
https://pubmed.ncbi.nlm.nih.gov/17204749
https://pubmed.ncbi.nlm.nih.gov/17204749
Autor:
Jose Eduardo Lopez, James H Wikel, Mary Margaret Mader, Beth A Hollister, Luisa M Martin Cabrejas, Beverly Teicher, James A Aikins, Enrique Alvarez, Philip A Hipskind, Deborah D Giera, Michael E Richett, Rafael Ferritto, Karen L Lobb, Denis J. McCann, Gregory L Durst, Wesley T White, Alfonso De Dios, Cora Sue Grossman, John E. Reilly, Eileen L Considine, Victoriano Molero, Shih Chuan, Tiechao Li, Ho-Shen Lin, Beatriz Lopez, Zhongping Huang, Philip W Iversen, Yiu-Yin Cheung, Kevin L Law
Publikováno v:
Journal of medicinal chemistry. 47(22)
Two closely related diaryl acylsulfonamides were recently reported as potent antitumor agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary, and prostate) in nude mice. Especially intriguing was their activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e5736c7618e19c7843e687523b3175
https://pubmed.ncbi.nlm.nih.gov/15481975
https://pubmed.ncbi.nlm.nih.gov/15481975
Autor:
Gerald F. Smith, Matthew J. Fisher, John E. Toth, Nickolay Y. Chirgadze, Deborah D. Giera, Dianna L. Bailey, John A. Buben, Amy Clemens-Smith, Michael L. Denney, Michael Enrico Richett, Richard Waltz Harper, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Valentine J. Klimkowski, Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Ho-Shen Lin, Daniel Jon Sall, Donetta S. Gifford-Moore, Lea M. Johnson, David W. Snyder
Publikováno v:
Journal of medicinal chemistry. 43(4)
A systematic investigation of the structure-activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent thrombin inhibitors 23c, 28c, and 31c. Their activities (1240, 903, and 1271 x 10(6) L/mol, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b65bb93c4bac89d1ca25c10915de94
https://pubmed.ncbi.nlm.nih.gov/10691691
https://pubmed.ncbi.nlm.nih.gov/10691691
Autor:
Nickolay Y. Chirgadze, Kenneth Lee Hauser, Ho-Shen Lin, Kenneth Jeff Thrasher, Stephen L. Briggs, Gerald F. Smith, Michael L. Denney, Sau-Chi B. Yan, Daniel Jon Sall, John A. Buben, K. Takeuchi, Donetta S. Gifford-Moore, Valentine J. Klimkowski, Jefferson Ray Mccowan, Barbara G. Utterback, David K. Clawson, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Richard Waltz Harper, Deborah D. Giera, Todd J. Kohn, Jennifer M. Tinsley
Publikováno v:
Journal of medicinal chemistry. 40(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e273868bb2a1580b5d2d0497e3331a9
https://pubmed.ncbi.nlm.nih.gov/9357512
https://pubmed.ncbi.nlm.nih.gov/9357512
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 16(2)
Assessment of hepatic ω-oxidation of fatty acids by cytochrome P450IV enzymes in toxicology studies can be a means of evaluating test compound effects on peroxisomal proliferation. Routine assay of ω-oxidation, however, requires a simpler method of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cd7a89d5c24e0156b419ca2055e7b1
https://pubmed.ncbi.nlm.nih.gov/2055365
https://pubmed.ncbi.nlm.nih.gov/2055365
Publikováno v:
Proceedings, annual meeting, Electron Microscopy Society of America. 50:612-613
In vitro exposure to LY237216 (9-Deoxo-11-deoxy-9,11-{imino[2-(2-methoxyethoxy)ethylidene]-oxy}-(9S)-erythromycin), a macrolide antibiotic, was found to induce cytoplasmic vacuolation in L6 skeletal muscle myoblast cultures (White, S.L., unpubl). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a26e5fcc626de1923d4fd2270c92053
https://doi.org/10.1017/s0424820100123465
https://doi.org/10.1017/s0424820100123465