Organoid microphysiological system preserves pancreatic islet function within 3D matrix

Autor: Peter Buchwald, Matthew Ishahak, Edward A. Phelps, Cherie L. Stabler, Deborah Chaimov, D. LaShoto, A. Velraj, Ashutosh Agarwal, S. N. Patel, D. W. Hagan

Publikováno v: Science Advances

A customized microphysiological system supports the perifusion and in situ multiparametric assessment of 3D islet organoids.
Three-dimensional (3D) multicellular organoids recapitulate the native complexities of human tissue better than traditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a7a85d88cd3055c857394a9d3709b0
https://doi.org/10.1126/sciadv.aba5515

Comprehensive characterization of the human pancreatic proteome for bioengineering applications

Autor: Shay Soker, Amish Asthana, Emmanuel C. Opara, Stephen J. Walker, Riccardo Tamburrini, John L. Robertson, Giuseppe Orlando, Sandrine Lablanche, Carlo Gazia, Alice A. Tomei, Mark Van Dyke, Deborah Chaimov

Publikováno v: Biomaterials. 270

Interactions between the pancreatic extracellular matrix (ECM) and islet cells are known to regulate multiple aspects of islet physiology, including survival, proliferation, and glucose-stimulated insulin secretion. Recognizing the essential role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a179bac46eb5bfd3a207907866f91486
https://pubmed.ncbi.nlm.nih.gov/33561625

Contributors

Autor: Tomohiko Adachi, Toshiyuki Adachi, Rodolfo Alejandro, Ana M. Alvarez, Domenico Alvaro, Spencer R. Andrei, Matthew Armfield, Amish Asthana, Stephen F. Badylak, David A. Baidal, Appakalai N. Balamurugan, Gianpaolo Balzano, Ipsita Banerjee, Kaylene Barrera, Will Bataller, Greg J. Beilman, Melena D. Bellin, Dora M. Berman, Louise Berry, Daniel Bojar, Rita Bottino, Nathaniel W. Brigle, Henry Buchwald, Jane N. Buchwald, Vincenzo Cardinale, Guido Carpino, Renee Cercone, Deborah Chaimov, Christopher G. Chapman, Amanda Child, Srinath Chinnakotla, Gaetano Ciancio, Kristin P. Colling, Marie Cook, David K.C. Cooper, Alexandria Coughlan, Rick de Vries, Juan Domínguez-Bendala, Ty B. Dunn, Susumu Eguchi, Massimo Falconi, Austin K. Feeney, Magali J. Fontaine, Benjamin S. Freedman, Virginia Fuenmayor, Martin Fussenegger, Maureen Gannon, Eugenio Gauido, Michael A. Goedde, Rainer W.G. Gruessner, Carolin Hermanns, Masaaki Hidaka, Masataka Hirabaru, Michael G. Hughes, Abid Hussain, Hajime Imamura, Marco Infante, G. Janani, Marlon Jetten, Christopher M. Jones, Jagan Kalivarathan, Mazhar A. Kanak, David L. Kaplan, Tatsuya Kin, Manishekhar Kumar, Jonathan R.T. Lakey, Giacomo Lanzoni, Emily J. Larkin, Esther Latres, Yoojin C. Lee, Elina Linetsky, Gopalakrishnan Loganathan, Elisa Maillard, Biman B. Mandal, Adela Helvia Martinez, Hajime Matsushima, Jeffrey B. Matthews, Kendall McEachron, Raffaella Melzi, Alessia Mercalli, Giovanni Migliaccio, Samantha A. Mitchell, Sami Mohammed, Sean Muir, Rita Nano, Siddharth Narayanan, Koji Natsuda, Jon S. Odorico, Shinichiro Ono, Giuseppe Orlando, Nathalia Padilla, Silvia Pellegrini, Laura Perin, Lorenzo Piemonti, Antonello Pileggi, Catalina Pineda Molina, Elizabeth C. Poli, Mirza Muhammad Fahd Qadir, Camillo Ricordi, L. Rodriguez Rilo, R. Paul Robertson, William Rust, Sara Dutton Sackett, Pratik Saxena, Alexander Schwartzman, Sarah J. Schwarzenberg, Michael V. Sefton, Sidharth Sharma, Benjamin Smood, Davide Socci, Valeria Sordi, Adam Stell, Aaron A. Stock, Mitsuhisa Takatsuki, Alice A. Tomei, Daniel M. Tremmel, Bernard E. Tuch, Vijayaganapathy Vaithilingam, Aart van Apeldoorn, Valentina Villani, Alexander E. Vlahos, Stuart K. Williams, Xiangwei Xiao, Kunal Yadav, Manpei Yamashita, Henryk Zulewski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cffbb876df39a69858e86447f2d48fb0
https://doi.org/10.1016/b978-0-12-814831-0.09992-9

Innovative encapsulation platform based on pancreatic extracellular matrix achieve substantial insulin delivery

Autor: I Meivar-Levy, Limor Baruch, Marcelle Machluf, Deborah Chaimov, S Ferber, Stasia Krishtul

Publikováno v: Journal of Controlled Release. 257:91-101

Cell-based therapies for the treatment of diabetes, generally aim to provide long-term glucose regulated-insulin delivery using insulin producing cells. The delivery platform is crucial for the therapeutic outcome as well as for immunoisolation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ddb1c99e628fc5a57fad70df710067
https://doi.org/10.1016/j.jconrel.2016.07.045

Scaffolds for pancreatic tissue engineering

Autor: Giuseppe Orlando, Carlo Gazia, Michaela Gaffley, Amish Asthana, Deborah Chaimov

Emerging technologies in regenerative medicine are crucial to overcome the organ donor shortage and the limitations in conventional diabetes treatments. A bioengineered pancreas, obtained through the development of a three-dimensional scaffold from b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdd3e97225cf4d114eb8fbbe59b6e2fe
https://doi.org/10.1016/b978-0-08-102561-1.00032-4