Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Deborah C.I. Goberdhan"'
Autor:
Rokaya El-Ansari, Syed Haider, Deborah C.I. Goberdhan, Alessandro Valli, Madeleine L. Craze, Emad A. Rakha, Matteo Morotti, Andrew R. Green, Adrian L. Harris, Christos E. Zois, Shih-Jung Fan
Publikováno v:
British Journal of Cancer
Background Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab77dd6b97ce5790d49376ab2f7a8e1
http://europepmc.org/articles/PMC7852531
http://europepmc.org/articles/PMC7852531
Autor:
Roger A. Barker, Clive Wilson, Wooi F. Lim, Alfina A Speciale, Thomas C. Roberts, André Görgens, Samir El Andaloussi, Imre Mäger, Matthew J.A. Wood, Cláudia C. Mendes, Ghulam Hassan Dar, Mariana Conceição, I. Uliyakina, Wei-Li Kuan, Deborah C.I. Goberdhan, Miguel J Lobo
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acf491285a58a837b79673ed6da4152
Autor:
Carina Gandy, Deborah C.I. Goberdhan, Freddie C. Hamdy, Sekar A, Sarma D, Josephine E. E. U. Hellberg, Cláudia C. Mendes, Aaron Leiblich, Clive Wilson, S M Wainwright
Dysregulation of cell cycle components results in the development and progression of several cancer types. Unusually, loss of the tumour suppressor gene,Retinoblastoma(Rb), and consequent activation of transcription factor E2F1 have been linked to la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d53281b9416c2f8c7d524df2d1038f
https://doi.org/10.1101/2021.03.27.437310
https://doi.org/10.1101/2021.03.27.437310
Autor:
John D. Mason, Clare Verrill, Shih-Jung Fan, Deborah C.I. Goberdhan, Richard J. Bryant, Kristie McCormick, Poohrawind Sanitt, Freddie C. Hamdy, Adrian L. Harris
Advanced prostate cancer is typically treated with anti-androgens to reduce cancer growth, but patients almost inevitably develop treatment resistance and castration-resistant disease. Recently, extracellular vesicles known as exosomes, which are sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbed0b1271b3ca0d3c75a602778ebc62
https://doi.org/10.1101/2020.09.18.300137
https://doi.org/10.1101/2020.09.18.300137
Autor:
Pauline P. Marie, Deborah C.I. Goberdhan, S. Mark Wainwright, Cláudia C. Mendes, Adrian L. Harris, Clive Wilson, Shih-Jung Fan
Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in multivesicular endosomes, which subsequently fuse with the plasma membrane. These ILVs are made in both late endosomes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9388020cdc73f3a55f4f20e7a60dea7a
https://doi.org/10.1101/2020.06.18.158725
https://doi.org/10.1101/2020.06.18.158725
Autor:
Pauline P. Marie, John F. Morris, Deborah C.I. Goberdhan, S. Mark Wainwright, Aaron Leiblich, Laura Corrigan, Rachel Patel, Stuart Wigby, Abigail Pavey, Benjamin Kroeger, Sekar A, Cláudia C. Mendes, Carina Gandy, Shih-Jung Fan, Josephine E. E. U. Hellberg, Clive Wilson
Seminal fluid plays an essential role in promoting male reproductive success and modulating female physiology and behaviour. In the fruit fly,Drosophila melanogaster, Sex Peptide (SP) is the best-characterised protein mediator of these effects. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa31aca515eb1e59ed31ec998a23953
https://doi.org/10.1101/2020.04.24.059238
https://doi.org/10.1101/2020.04.24.059238
Autor:
Deborah C.I. Goberdhan, Derek Nye, J. Ian Hertzler, Richard M. Albertson, Kevin A. Janes, Alexis T. Weiner, Clive Wilson, Matthew Shorey, Melissa M. Rolls
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000657 (2020)
PLoS Biology
PLoS Biology
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model of dendrite regeneration, we performed a candidate screen of receptor tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9ab93d6841c1cb8742e3325a77d757
https://ora.ox.ac.uk/objects/uuid:939e2050-3287-4c71-be79-f84ec9f635e0
https://ora.ox.ac.uk/objects/uuid:939e2050-3287-4c71-be79-f84ec9f635e0
Autor:
Clive Wilson, Kuan W-L., Ghulam Hassan Dar, Thomas C. Roberts, Mariana Conceição, Deborah C.I. Goberdhan, Samir El-Andaloussi, C De Almeida Mendes, Imre Mäger, Matthew J.A. Wood, Roger A. Barker
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication and pathophysiology. Their capacity to transfer biomolecules between cells has sparked efforts to bioengineer EVs as drug delivery vehicles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f904048127a445f9cf56dec29ce7cf
Autor:
M. Irina Stefana, Cláudia C. Mendes, Christos E. Zois, John F. Morris, Freddie C. Hamdy, Kristie McCormick, Nasullah Khalid Alham, Deborah C.I. Goberdhan, S. Mark Wainwright, Errin Johnson, Esther Bridges, Benjamin Kroeger, Helen Sheldon, Matthew Ellis, Adrian L. Harris, Clive Wilson, Shih-Jung Fan, Pauline P. Marie, John D. Mason, Christopher M. Cunningham
SUMMARYExosomes are secreted extracellular vesicles (EVs) carrying diverse cargos, which can modulate recipient cell behaviour. They are thought to derive from intraluminal vesicles formed in late endosomal multivesicular bodies (MVBs). An alternate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836904884fbfb78d93e32368a669d653
https://doi.org/10.1101/859447
https://doi.org/10.1101/859447
Autor:
John Mason, Mark Wainwright, Aaron Leiblich, Clive Wilson, Freddie C. Hamdy, Deborah C.I. Goberdhan, Cláudia C. Mendes, Josephine E. E. U. Hellberg, Carina Gandy, Pauline P. Marie, Sekar A, Siamak Redhai
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000145 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000145 (2019)
Male reproductive glands like the mammalian prostate and the paired Drosophila melanogaster accessory glands secrete seminal fluid components that enhance fecundity. In humans, the prostate, stimulated by environmentally regulated endocrine and local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac23f7f01ccf7d8277484e710e61655
https://doi.org/10.1371/journal.pbio.3000145
https://doi.org/10.1371/journal.pbio.3000145