Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Deborah C, Otteson"'
Publikováno v:
Stem Cells International, Vol 2017 (2017)
In humans and other mammals, the neural retina does not spontaneously regenerate, and damage to the retina that kills retinal neurons results in permanent blindness. In contrast to embryonic stem cells, induced pluripotent stem cells, and embryonic/f
Externí odkaz:
https://doaj.org/article/bbace99e44bd49bfa271b4ce7efcbb1e
Autor:
Mark K. Webster, Cindy L. Linn, Sarah E. Webster, Cynthia A. Cooley-Themm, Deborah C. Otteson, Joshua R. Paris, Megan L. Stanchfield, Betty J. Barnett, Edward M. Levine
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The adult mammalian retina is typically incapable of regeneration when damaged by disease or trauma. Restoration of function would require generation of new adult neurons, something that until recently, mammals were thought to be incapable of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bb3df08ab37b280fa3fc9437807191
http://europepmc.org/articles/PMC6363405
http://europepmc.org/articles/PMC6363405
Autor:
Jake B. Spitsbergen, Megan L. Stanchfield, Mark K. Webster, Deborah C. Otteson, Nathan C. Sklar, Sarah E. Webster, David M. Linn, Cindy L. Linn
Publikováno v:
Exp Eye Res
The adult mammal lacks the ability to regenerate neurons lost to retinal damage or disease in a meaningful capacity. However, previous studies from this laboratory have demonstrated that PNU-282987, an α7 nicotinic acetylcholine receptor agonist, el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc766936e47fab7c8d4cedc449e2433a
https://pubmed.ncbi.nlm.nih.gov/34348130
https://pubmed.ncbi.nlm.nih.gov/34348130
Autor:
Deborah C. Otteson
Publikováno v:
Neuroscience. 346:447-449
World-wide, two degenerative retinal diseases, glaucoma and age-related macular degeneration, are estimated to affect more than 12% of individuals over the age of 40 (Tham et al., 2014; Wong et al., 2014). Current therapies can slow progression, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb27316e899c03b3c8f68a9688dcd2
https://doi.org/10.1016/j.neuroscience.2017.01.022
https://doi.org/10.1016/j.neuroscience.2017.01.022
Autor:
Subramanian Dharmarajan, Teri L. Belecky-Adams, Ankita Saha, Sarika Tiwari, Deborah C. Otteson
Publikováno v:
Gene expression patterns : GEP. 30
Background The acetylation state of histones has been used as an indicator of the developmental state of progenitor and differentiating cells. The goal of this study was to determine the nuclear localization patterns of Class I histone deacetylases (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaee948b80cfb074c77d46b410ee2b5
https://pubmed.ncbi.nlm.nih.gov/30179675
https://pubmed.ncbi.nlm.nih.gov/30179675
Publikováno v:
Current eye research. 42(11)
Antimicrobial peptides (AMPs) have been implicated in the pathogenesis of several cancers, although there is also evidence suggesting potential for novel, AMP-based antitumor therapies. Discerning potential roles of AMPs in tumor pathogenesis may pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7d0061ca9b4da2696bfcc86a8ed4fd
https://pubmed.ncbi.nlm.nih.gov/28910167
https://pubmed.ncbi.nlm.nih.gov/28910167
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Stem Cells International
Stem Cells International
In humans and other mammals, the neural retina does not spontaneously regenerate, and damage to the retina that kills retinal neurons results in permanent blindness. In contrast to embryonic stem cells, induced pluripotent stem cells, and embryonic/f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e269079c66509e78a284509e7c041139
https://doaj.org/article/bbace99e44bd49bfa271b4ce7efcbb1e
https://doaj.org/article/bbace99e44bd49bfa271b4ce7efcbb1e
Autor:
Raul Urrutia, Joana Galvao, Jianbo Wang, Weijia Luo, Deborah C. Otteson, Jeffrey L. Goldberg, Krista M. Beach
Publikováno v:
The Journal of biological chemistry. 291(41)
Regenerative medicine holds great promise for the treatment of degenerative retinal disorders. Kruppel-like factors (KLFs) are transcription factors that have recently emerged as key tools in regenerative medicine because some of them can function as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9550e9b8ed5475bd8b5dd9651f1916d
https://pubmed.ncbi.nlm.nih.gov/27402841
https://pubmed.ncbi.nlm.nih.gov/27402841
Publikováno v:
Vision Research. 51(2):260-268
Understanding the mechanisms regulating expression of retinal ganglion cell (RGC) specific and axon-guidance genes during development and in retinal stem cells will be critical for successful optic nerve regeneration. Müller glia have some character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ab5fb21f37d0925b053d4dc37aee02
Publikováno v:
The Journal of Comparative Neurology. 518:2071-2089
The Pde6b(rd10) (rd10) mouse has a moderate rate of photoreceptor degeneration and serves as a valuable model for human autosomal recessive retinitis pigmentosa (RP). We evaluated the progression of neuronal remodeling of second- and third-order reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fd29f70bcf3095a657f1f668cbf2cd
https://doi.org/10.1002/cne.22322
https://doi.org/10.1002/cne.22322