Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Deborah Bahr"'
Autor:
Emmanuel M. Gabriel, Brian Necela, Deborah Bahr, Sneha Vivekanandhan, Barath Shreeder, Sanjay Bagaria, Keith L. Knutson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In this study, we tested a novel approach of “repurposing” a biomarker typically associated with breast cancer for use in melanoma. HER2/neu is a well characterized biomarker in breast cancer for which effective anti-HER2/neu therapies a
Externí odkaz:
https://doaj.org/article/15cf9697167549baa914c2e9e20348c7
Autor:
Sneha Vivekanandhan, Deborah Bahr, Ashish Kothari, Mohammed Ali Ashary, Mizba Baksh, Emmanuel Gabriel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Cancer remains a leading cause of death worldwide, placing a significant burden on healthcare systems as well as the global economy. Rare cancers comprise a group of about 200 cancers that individually occur at extremely low frequencies. In
Externí odkaz:
https://doaj.org/article/20004e113736406faabd3a576d95d3fd
Autor:
Keith L. Knutson, Martin J. Cannon, Matthew S. Block, Ellen L. Goode, Kimberly R. Kalli, Joshua Daum, Deborah Bahr, James Krempski, Barath Shreeder, Lavakumar Karyampudi, Purushottam Lamichhane
Ligation of programmed cell death-1 (PD-1) in the tumor microenvironment is known to inhibit effective adaptive antitumor immunity. Blockade of PD-1 in humans has resulted in impressive, durable regression responses in select tumor types. However, du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1526fefa0d977e5e6e0f4eda9487c73
https://doi.org/10.1158/0008-5472.c.6509550
https://doi.org/10.1158/0008-5472.c.6509550
Autor:
Keith L. Knutson, Martin J. Cannon, Matthew S. Block, Ellen L. Goode, Kimberly R. Kalli, Joshua Daum, Deborah Bahr, James Krempski, Barath Shreeder, Lavakumar Karyampudi, Purushottam Lamichhane
Expression of PD-1 on BMDCs and T cells after exposure to IL-6 and IL-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41564667fab3bf2525b49273bfdd665b
https://doi.org/10.1158/0008-5472.22416429.v1
https://doi.org/10.1158/0008-5472.22416429.v1
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 6-6 (2020)
OBJECTIVES/GOALS: Our overall objective is to develop a directly observable and reproducible method of enhanced blood flow through tumor vessels (i.e. dynamic control) at the time of systemic treatment delivery. Our central hypothesis is that the dyn
Externí odkaz:
https://doaj.org/article/ba51f9b522454875bffd154a26129dca
Autor:
Emmanuel M. Gabriel, Brian Necela, Deborah Bahr, Jamie Kaplan, Kristopher Attwood, Keith Knutson
Publikováno v:
Cancer Research. 82:5371-5371
INTRODUCTION: HER2/neu is a potent biomarker for which anti-HER2/neu antibodies offer significant responses. However, many cancers, such as melanoma, have less than 5% expression of HER2/neu. The purpose of this study was to determine whether induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed43d8c15998f40cb9f31b6ec580963b
https://doi.org/10.1158/1538-7445.am2022-5371
https://doi.org/10.1158/1538-7445.am2022-5371
Autor:
Emmanuel M. Gabriel, Vijay Madamsetty, Deborah Bahr, Jamie Kaplan, Kristopher Attwood, Sanjay Bagaria, Keith Knutson, Debabrata Mukhopadhyay
Publikováno v:
Cancer Research. 82:5071-5071
INTRODUCTION: Intratumoral phenylephrine (α1 vasoconstrictor) combined with chemotherapy has been used for cutaneous malignancies with modest local response. The purpose of this study was to improve the efficacy of intratumoral melphalan using susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89965f53791c6706e07da483183c743
https://doi.org/10.1158/1538-7445.am2022-5071
https://doi.org/10.1158/1538-7445.am2022-5071
Publikováno v:
Journal of Clinical and Translational Science. 4:6-6
OBJECTIVES/GOALS: Our overall objective is to develop a directly observable and reproducible method of enhanced blood flow through tumor vessels (i.e. dynamic control) at the time of systemic treatment delivery. Our central hypothesis is that the dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357ec2216a995f9fa2c7cb767c6128a5
https://doi.org/10.1017/cts.2020.64
https://doi.org/10.1017/cts.2020.64
Autor:
Purushottam Lamichhane, Martin J. Cannon, Lavakumar Karyampudi, Deborah Bahr, Keith L. Knutson, Barath Shreeder, Joshua Daum, Ellen L. Goode, Matthew S. Block, Kimberly R. Kalli, James Krempski
Publikováno v:
Cancer research. 77(23)
Ligation of programmed cell death-1 (PD-1) in the tumor microenvironment is known to inhibit effective adaptive antitumor immunity. Blockade of PD-1 in humans has resulted in impressive, durable regression responses in select tumor types. However, du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756577ec53eab61d273a074a9307b891
https://pubmed.ncbi.nlm.nih.gov/28993412
https://pubmed.ncbi.nlm.nih.gov/28993412
Autor:
Geraldine Raja, Keith L. Knutson, Yan Luo, Martin J. Cannon, Navnita Dutta, Deborah Bahr, Shreeder Barath
Publikováno v:
Cancer Research. 79:1464-1464
Dendritic cells (DCs) are the most potent antigen-presenting cells which bridges innate and adaptive immunity, but how DC-derived signals regulate and induce T cell lineage choices remains unclear. The p38 MAPK pathway plays an essential role in regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7443a0c09099ebce2d8ae0cfa3bb1ce
https://doi.org/10.1158/1538-7445.am2019-1464
https://doi.org/10.1158/1538-7445.am2019-1464