Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Deborah B. Dehart"'
Autor:
Robert J Lipinski, Peter Hammond, Shonagh K O'Leary-Moore, Jacob J Ament, Stephen J Pecevich, Yi Jiang, Francois Budin, Scott E Parnell, Michael Suttie, Elizabeth A Godin, Joshua L Everson, Deborah B Dehart, Ipek Oguz, Hunter T Holloway, Martin A Styner, G Allan Johnson, Kathleen K Sulik
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43067 (2012)
Prenatal ethanol exposure is the leading preventable cause of congenital mental disability. Whereas a diagnosis of fetal alcohol syndrome (FAS) requires identification of a specific pattern of craniofacial dysmorphology, most individuals with behavio
Externí odkaz:
https://doaj.org/article/f002b2c989d34d4bb0b782c406b0b246
Autor:
Deborah B. Dehart, Kathleen K. Sulik, Elizabeth A. Godin, Shonagh K. O'Leary-Moore, Scott E. Parnell
Publikováno v:
Neurotoxicology and Teratology. 33:231-239
Ethanol exposure on gestational day (GD) 7 in the mouse has previously been shown to result in ventromedian forebrain deficits along with facial anomalies characteristic of fetal alcohol syndrome (FAS). To further explore ethanol's teratogenic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c63074f0eb788b88a682a630f6066cd
https://doi.org/10.1016/j.ntt.2010.11.001
https://doi.org/10.1016/j.ntt.2010.11.001
Publikováno v:
Alcohol. 44:699-705
N-Acetylcysteine (NAC) is a derivative of the amino acid l -cysteine, which, previously, has been shown to protect against ethanol-induced apoptosis during early development. Ongoing research demonstrates that NAC is also proving clinically beneficia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0cf4d29bb60332f8eae9a29cd1557f
https://doi.org/10.1016/j.alcohol.2010.05.006
https://doi.org/10.1016/j.alcohol.2010.05.006
Autor:
Kathleen K. Sulik, Deborah B. Dehart, Brice W. Johnson, Martin Styner, Elizabeth A. Godin, Amber A. Khan, Shonagh K. O'Leary-Moore, Jacob J. Ament, G. Allan Johnson, Scott E. Parnell
Publikováno v:
Alcoholism: Clinical and Experimental Research. 34:98-111
Background: This magnetic resonance microscopy (MRM)-based report is the second in a series designed to illustrate the spectrum of craniofacial and central nervous system (CNS) dysmorphia resulting from single- and multiple-day maternal ethanol treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d86b3a0594495f0e8b3a60ecb58751
https://doi.org/10.1111/j.1530-0277.2009.01071.x
https://doi.org/10.1111/j.1530-0277.2009.01071.x
Autor:
Shao-Yu Chen, Tiffany A. Wills, Joyce Besheer, Kathleen K. Sulik, Deborah B. Dehart, Scott E. Parnell, Clyde W. Hodge, Michael E. Charness, Heather G. Waage-Baudet
Publikováno v:
Alcoholism: Clinical and Experimental Research. 30:1791-1798
Background: This work was conducted in an effort to establish an oral intake model system in which the effects of ethanol insult that occur during early stages of embryogenesis can be easily examined and in which agents that may modulate ethanol's te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bb9adc96c76aef3f7e90b4af55555
https://doi.org/10.1111/j.1530-0277.2006.00212.x
https://doi.org/10.1111/j.1530-0277.2006.00212.x
Autor:
Kathy K. Niakan, Meisheng Jiang, Edward R.B. McCabe, Emily C. Davis, Deborah B. Dehart, Robert C. Clipsham, Kathleen K. Sulik
Publikováno v:
Molecular Genetics and Metabolism. 88:261-271
Cytomegalic adrenal hypoplasia congenita (AHC) is an X-linked disease caused by mutations in DAX1-encoding gene NR0B1 , previously thought to function primarily in steroidogenesis. We sought to determine the expression pattern for Dax1 along with kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b81b09c892fc96377c82f5f4045d58
https://doi.org/10.1016/j.ymgme.2005.12.010
https://doi.org/10.1016/j.ymgme.2005.12.010
Publikováno v:
Alcoholism: Clinical and Experimental Research. 25:1523-1535
Background: Ethanol-induced cell death has been characterized in very few stages of embryogenesis. This investigation comprehensively maps patterns of both programmed and ethanol-induced cell death in the central nervous system and craniofacial regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d574016b6419dd3c321a3c33b4eccd
https://doi.org/10.1111/j.1530-0277.2001.tb02156.x
https://doi.org/10.1111/j.1530-0277.2001.tb02156.x
Autor:
Deborah B. Dehart, Nobuyo Maeda, G. Stephen Tint, Kathleen K. Sulik, Myron E. Hinsdale, Louise Lanoue
Publikováno v:
American Journal of Medical Genetics. 73:24-31
Low cholesterol levels produced by treating cholesterol deficient mutant mice with a cholesterol synthesis inhibitor (BM 15.766) between days 4 to 7 of pregnancy resulted in malformations consistent with those in the Smith-Lemli-Opitz syndrome (SLOS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4729a95cfd110bc263ad291c12718a40
https://doi.org/10.1002/(sici)1096-8628(19971128)73:1<24::aid-ajmg6>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19971128)73:1<24::aid-ajmg6>3.0.co
Publikováno v:
American Journal of Medical Genetics. 68:328-337
The fact that Smith-Lemli-Opitz syndrome (SLOS), a syndrome comprising major malformations involving a number of organ systems, results from an abnormality in cholesterol biosynthesis, was discovered only recently. Utilizing a drug (BM 15.766) to inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f183d35d64986512825bcb88a7346356
https://doi.org/10.1002/(sici)1096-8628(19970131)68:3<328::aid-ajmg15>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19970131)68:3<328::aid-ajmg15>3.0.co
Autor:
Hunter T. Holloway, Kathleen K. Sulik, G. Allan Johnson, Shonagh K. O'Leary-Moore, Francois Budin, Deborah B. Dehart, Beatriz Paniaqua, Ipek Oguz, Martin Styner, Scott E. Parnell
Animal model-based studies have shown that ethanol exposure during early gestation induces developmental stage-specific abnormalities of the face and brain. The exposure time-dependent variability in ethanol's teratogenic outcomes is expected to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1526f042501566593551f519b96b15
