11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Autor: Mohini Gray, John Savill, Karen E. Chapman, Deborah A. Sawatzky, David G. Brownstein, Agnes E. Coutinho, Donald Salter, Spike Clay, James S. Gilmour, Jonathan R. Seckl

Publikováno v: Endocrinology
Coutinho, A E, Gray, M, Brownstein, D G, Salter, D M, Sawatzky, D A, Clay, S, Gilmour, J S, Seckl, J R, Savill, J S & Chapman, K E 2012, ' 11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice ', Endocrinology, vol. 153, no. 1, pp. 234-240 . https://doi.org/10.1210/en.2011-1398

Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7006b8f3eae562822ed57be88aa92b88
https://doi.org/10.1210/en.2011-1398

Granulocyte Apoptosis and Macrophage Clearance of Apoptotic Cells as Targets for Pharmacological Intervention in Inflammatory Diseases

Autor: Christopher Haslett, Tara A. Sheldrake, Carol Ward, Deborah A. Sawatzky, Ian Dransfield, Adriano G. Rossi, Nicola A. Riley

Publikováno v: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5:3-12

A subset of leukocytes, known as the granulocytes, are the bodys first line of innate immune defense. The granulocytes are comprised of neutrophils, eosinophils and basophils of which the former two will be the focus of this review. Neutrophils defen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f0338e0672841bbec89552423350bc9
https://doi.org/10.2174/187152306775537319

Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation

Autor: Emma Court, Richard W. Costello, Deborah A. Sawatzky, W. Graham McLean, Bharathy Kumaravel, David B. Jacoby, Paul J. Kingham, Allison D. Fryer

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L1279-L1288

In vivo, eosinophils localize to airway cholinergic nerves in antigen-challenged animals, and inhibition of this localization prevents antigen-induced hyperreactivity. In this study, the mechanism of eosinophil localization to nerves was investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd91a95da62f30cfaad748b735478e14
https://doi.org/10.1152/ajplung.00279.2001

Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation

Autor: Richard A. Lang, David C. Kluth, Kris Houlberg, Dave Walbaum, Tiina Kipari, Jeremy Hughes, Deborah A. Sawatzky, Jean Francois Cailhier, Simon Watson, John Savill, Spike Clay

Publikováno v: Cailhier, J F, Sawatzky, D A, Kipari, T, Houlberg, K, Walbaum, D, Watson, S, Lang, R A, Clay, S, Kluth, D, Savill, J & Hughes, J 2006, ' Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation ', American Journal of Respiratory and Critical Care Medicine, vol. 173, no. 5, pp. 540-7 . https://doi.org/10.1164/rccm.200504-538OC

Rationale: The role played by resident pleural macrophages in the initiation of pleural inflammation is currently unclear.Objective: To evaluate the role of resident pleural macrophages in the initiation of inflammation.Methods: We have used a condit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b41132c22c0d679e7f2f27978f76bd
https://www.pure.ed.ac.uk/ws/files/8664993/Resident_pleural_macrophages_are_key_orchestrators_of_neutrophil_recruitment_in_pleural_inflammation.pdf

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

Autor: Morag C. Martin, Annemieke Walker, Rodger Duffin, Deborah A. Sawatzky, Adriano G. Rossi, Trevor R. Walker, Elvira Crescenzi, Alison Caldicott, Christopher Haslett, Nicola A. Riley, Tara A. Sheldrake, Ian Dransfield, Mohini Gray, John Savill, Hugh J.M. Brady, Magdalena Martinez-Losa, Carol Ward

Publikováno v: Nature medicine
12 (2006): 1056–1064. doi:10.1038/nm1468
info:cnr-pdr/source/autori:Rossi AG; Sawatzky DA; Walker A; Ward C; Sheldrake TA; Riley NA; Caldicott A; Martinez-Losa M; Walker TR; Duffin R; Gray M; Crescenzi E; Martin MC; Brady HJ; Savill JS; Dransfield I; Haslett C./titolo:Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis/doi:10.1038%2Fnm1468/rivista:Nature medicine (Print)/anno:2006/pagina_da:1056/pagina_a:1064/intervallo_pagine:1056–1064/volume:12

Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of inflammation. Here we report that human neutrophils contain functionally active cyclin-dependent kinases (CDKs), and that structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b07eb7c5635449f1b10c3838ae461fe