Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Deborah A. Nicoll-Griffith"'
Publikováno v:
Drug-Drug Interactions ISBN: 9780429131967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3be0c1eb3b9a00df7d7977b498983936
https://doi.org/10.1201/9780429131967-6
https://doi.org/10.1201/9780429131967-6
Autor:
Richard Soll, Sheo B. Singh, Peter T. Meinke, Wanying Sun, Lovji D. Cama, Li Wang, Deborah A. Nicoll-Griffith, Michael J. Hafey, Hongshi Yu, Takao Suzuki, Hao Wu, Diane Rindgen, Basheng Zhang, David B. Olsen, Nengxue Wang, Bradley Prudence K, Chongmin Ji
Publikováno v:
ACS Medicinal Chemistry Letters. 4:715-719
Carbapenems are intravenous lifesaving hospital antibiotics. Once patients leave the hospital, they are sent home with antibiotics other than carbapenems since they cannot be administered orally due to lack of oral absorption primarily because of ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94296f59abf183723a6a4c18232ff8f9
https://doi.org/10.1021/ml400092n
https://doi.org/10.1021/ml400092n
Autor:
Christophe Mellon, Nathalie Méthot, Deborah A. Nicoll-Griffith, Momar Ndao, Frédéric Massé, Christian Beaulieu, Angélique Fortier, Hyeram Park, W. Cameron Black, Elise Isabel, Doris Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7444-7449
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. The identified inhibitors bearing an amino nitrile warhead in P1 exhibit low nanomolar in vitro potency against cruzipain. Further SAR in P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6582e07a38a94405e3fdc8c323756d1
https://doi.org/10.1016/j.bmcl.2010.10.015
https://doi.org/10.1016/j.bmcl.2010.10.015
Autor:
W. Cameron Black, Jean-François Lévesque, Denis Riendeau, Jean-Pierre Falgueyret, Kevin P. Bateman, M. David Percival, Elise Isabel, Tammy LeRiche, Vouy Linh Truong, Jacques Yves Gauthier, Michel Therien, Robert Zamboni, Sevgi B. Rodan, Sylvie Desmarais, Christophe Mellon, Deborah A. Nicoll-Griffith, Renata Oballa, Gregg Wesolowski, Sonia Lamontagne, Carmai Seto, Nathalie Chauret, Chun Sing Li, Robert N. Young, Frédéric Massé, Wanda Cromlish, Daniel J. McKay, Le T. Duong, Cheuk K. Lau, Serge Leger, Joel Robichaud, Gideon A. Rodan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:887-892
MK-0674 is a potent and selective cathepsin K inhibitor from the same structural class as odanacatib with a comparable inhibitory potency profile against Cat K. It is orally bioavailable and exhibits long half-life in pre-clinical species. In vivo st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ce075aa9949065722c92768a34c9f4
https://doi.org/10.1016/j.bmcl.2009.12.083
https://doi.org/10.1016/j.bmcl.2009.12.083
Autor:
Kevin P. Bateman, Christopher S. Hughes, Jean-François Lévesque, † and Deborah A. Nicoll-Griffith, Sylvain Letarte, Jin Wu, Mireille Gaudreault, Pierre Picard
Publikováno v:
Analytical Chemistry. 79:4657-4665
This paper describes the development of a high-throughput method for the analysis of cytochrome P450 (CYP) inhibition assay incubation samples using laser diode thermal desorption interfaced with atmospheric pressure chemical ionization mass spectrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7384202be64a198dd4996168d4ec80d
https://doi.org/10.1021/ac070221o
https://doi.org/10.1021/ac070221o
Autor:
Judith Naud, Deborah A. Nicoll-Griffith, François A. Leblond, Vincent Pichette, Karine Desbiens, Caroline Boisvert, Josée Michaud
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 55:209-213
Introduction Quantification of cytochrome P 450 is a major issue in the development of new drugs. Different assays have been reported, but few are very selective for the 3A isoform or cytochrome P 450. The benzyloxy-substituted lactone cyclooxygenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b9b010606dcd8bda4d043dfc39fb82
https://doi.org/10.1016/j.vascn.2006.07.002
https://doi.org/10.1016/j.vascn.2006.07.002
Autor:
Jean François Lévesque, Matt Braun, Robert Zamboni, Claudio Sturino, Laird A. Trimble, Robert N. Young, Deborah A. Nicoll-Griffith, Stephen Day, Carmai Seto, Nathalie Chauret, Carl Berthelette, Yves Aubin, Jean-François Truchon, José M. Silva, Nicolas Lachance, Zhaoyin Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:301-304
Metabolites of the potent DP antagonist, MK-0524, were generated using in vitro systems including hepatic microsomes and hepatocytes. Four metabolites (two hydroxylated diastereomers, a ketone and an acyl glucuronide) were characterized by LC-MS/MS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a6e13af160d4760d91cec723a15a4f
https://doi.org/10.1016/j.bmcl.2006.10.055
https://doi.org/10.1016/j.bmcl.2006.10.055
Autor:
Yves Girard, Dwight Macdonald, Deborah A. Nicoll-Griffith, Michel Gallant, Nathalie Chauret, Daniel Dube, Anthony Mastracchio, Laird A. Trimble, Kevin P. Bateman, José M. Silva, Stephen Day, Helene Perrier
Publikováno v:
Journal of Mass Spectrometry. 41:771-780
L-454,560 is a potent phospodiesterase 4 (PDE4) inhibitor which was identified as a development candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). As part of the discovery of this compound, interspecies in vitro m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1928b6590a4e2d0d6824c8c9bf46cf74
https://doi.org/10.1002/jms.1033
https://doi.org/10.1002/jms.1033
Autor:
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Patrick Lacombe, Denis Deschênes, Bruno Roy, John Scheigetz, Kevin Bateman, Chun Li, Laird A. Trimble, Stephen Day, Nathalie Chauret, Deborah A. Nicoll-Griffith, Jose M. Silva, Zheng Huang, France Laliberté, Susana Liu, Diane Ethier, Doug Pon, Eric Muise, Louise Boulet, Chi Chung Chan, Angela Styhler, Stella Charleson, Joseph Mancini, Paul Masson, David Claveau, Donald Nicholson, Mervyn Turner, Robert N. Young, Yves Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5241-5246
The discovery and SAR of a new series of substituted 8-arylquinoline PDE4 inhibitors are herein described. This work has led to the identification of several compounds with excellent in vitro and in vivo profiles, including a good therapeutic window
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff58af67854878403c87410ee5934af1
https://doi.org/10.1016/j.bmcl.2005.08.036
https://doi.org/10.1016/j.bmcl.2005.08.036
Publikováno v:
Rapid Communications in Mass Spectrometry. 19:1984-1992
Discovery stage studies that address issues of absorption, distribution, metabolism and excretion (ADME) are vital for lead optimization resulting in new drug candidates. Often pharmacokinetics (PK) is assessed in these experiments without regard for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90774b89003a80506ac40d992db05ccf
https://doi.org/10.1002/rcm.2013
https://doi.org/10.1002/rcm.2013