Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Deborah A Siwik"'
Autor:
Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Aly Elezaby, Xiaoyan Yin, Deborah A Siwik, Francesca Seta, Catherine E Costello, Richard A Cohen, Reiko Matsui, Wilson S Colucci, Mark E McComb, Markus M Bachschmid
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144025 (2015)
Reactive protein cysteine thiolates are instrumental in redox regulation. Oxidants, such as hydrogen peroxide (H2O2), react with thiolates to form oxidative post-translational modifications, enabling physiological redox signaling. Cardiac disease and
Externí odkaz:
https://doaj.org/article/17226e23b1354d9a9df939a220b367f6
Autor:
Xiaoyong Tong, Marcello Panagia, Fuzhong Qin, Deborah A. Siwik, Jena B Goodman, Dominique Croteau, David R. Pimentel, Richard A. Cohen, Ion A. Hobai, Ivan Luptak, Markus Bachschmid, Wilson S. Colucci, Robert J. Morgan, Jordan M. Chambers
Publikováno v:
Circulation. 142:2459-2469
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b9e430b2767de44628df18b63300779
https://doi.org/10.1161/circulationaha.120.048183
https://doi.org/10.1161/circulationaha.120.048183
Autor:
Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16203839faa370c679548b749eaa129
http://europepmc.org/articles/PMC8403324
http://europepmc.org/articles/PMC8403324
Autor:
Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v:
Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::745c6cf907599986b5cff1d79bd630c2
https://doi.org/10.1161/circ.142.suppl_3.16641
https://doi.org/10.1161/circ.142.suppl_3.16641
Autor:
Fuzhong Qin, Deborah A. Siwik, David R. Pimentel, Ivan Luptak, Marcello Panagia, Dominique Croteau, Jordan M. Chambers, Wilson S. Colucci, Ethan Kallick
Publikováno v:
JACC. Basic to translational science. 5(9)
Highlights •MHD associated with obesity, diabetes, and/or metabolic syndrome is an important precursor of HFpEF. •Mice fed a HFHS diet develop MHD with myocardial hypertrophy, fibrosis, diastolic dysfunction, and impaired energetics. •Mice on H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860f711e67b12791891a81545cd7f650
https://pubmed.ncbi.nlm.nih.gov/33016957
https://pubmed.ncbi.nlm.nih.gov/33016957
Autor:
Marcello Panagia, Deborah A. Siwik, James A. Balschi, Fuzhong Qin, Huamei He, David R. Pimentel, Dominique Croteau, Wilson S. Colucci, Markus Bachschmid, Aaron L. Sverdlov, Ivan Luptak
Publikováno v:
Antioxid Redox Signal
Aims: Metabolic syndrome is associated with metabolic heart disease (MHD) that is characterized by left ventricular (LV) hypertrophy, interstitial fibrosis, contractile dysfunction, and mitochondrial dysfunction. Overexpression of catalase in mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f22eb1b2eef9b35472d08b4295db58d
https://europepmc.org/articles/PMC6648235/
https://europepmc.org/articles/PMC6648235/
Autor:
Deborah A. Siwik, Deepa M. Gopal, Wilson S. Colucci, Noyan Gokce, Nir Ayalon, Marcello Panagia, Jill Downing, Chang Seng Liang, Aaron L. Sverdlov, Alejandro J. Perez, Courtney Donohue, Jennifer E. Ho, Vanessa Silva, Yi-Chih Wang, Vijaya B. Kolachalama, Caroline M. Apovian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high‐risk individuals for heart failure prevention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f4af6f6b07360528f42f56b1ecd67
http://europepmc.org/articles/PMC6509711
http://europepmc.org/articles/PMC6509711
Autor:
Catherine Valentine, Daniel G. Remick, Dominique Croteau, Deborah A. Siwik, Fuzhong Qin, Ivan Luptak, Wilson S. Colucci, Ion A. Hobai
Publikováno v:
Shock (Augusta, Ga.). 52(1)
Mice challenged with lipopolysaccharide develop cardiomyopathy in a sex and redox-dependent fashion. Here we extended these studies to the cecal ligation and puncture (CLP) model.We compared male and female FVB mice (wild type, WT) and transgenic lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e0e04b0e42a0b2a6b0cca68f4b5e5d
https://pubmed.ncbi.nlm.nih.gov/30102640
https://pubmed.ncbi.nlm.nih.gov/30102640
Publikováno v:
Journal of Surgical Research. 193:888-901
Background Sepsis-induced cardiomyopathy (SIC) is thought to be the result of detrimental effects of inflammatory mediators on the cardiac muscle. Here we studied the effects of prolonged (24 ± 4 h) exposure of adult rat ventricular myocytes (ARVM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3470775a9d06d5317fc3be22994b7e42
https://doi.org/10.1016/j.jss.2014.09.015
https://doi.org/10.1016/j.jss.2014.09.015
Autor:
Ion A. Hobai, Natasha Khona, Wilson S. Colucci, Deborah A. Siwik, Joanne Huang, Justin C. Morse, Edward J. Miller
Publikováno v:
Anesthesiology. 126(6)
Background In surviving patients, sepsis-induced cardiomyopathy is spontaneously reversible. In the absence of any experimental data, it is generally thought that cardiac recovery in sepsis simply follows the remission of systemic inflammation. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed44a8eb1a287eff1a9a1feb897a49eb
https://pubmed.ncbi.nlm.nih.gov/28410273
https://pubmed.ncbi.nlm.nih.gov/28410273