Zobrazeno 1 - 10 of 108 pro vyhledávání: '"Deborah A Siwik"'
1
Akademický článek
Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice
Autor: Dominique Croteau, Ivan Luptak, Jordan M. Chambers, Ion Hobai, Marcello Panagia, David R. Pimentel, Deborah A. Siwik, Fuzhong Qin, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz: https://doaj.org/article/cb89ff2bb7ca44b79b60b9cd0761c0c1
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2
Akademický článek
Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet‐Induced Metabolic Heart Disease
Autor: Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz: https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
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4
Akademický článek
Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins.
Autor: Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Aly Elezaby, Xiaoyan Yin, Deborah A Siwik, Francesca Seta, Catherine E Costello, Richard A Cohen, Reiko Matsui, Wilson S Colucci, Mark E McComb, Markus M Bachschmid
Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144025 (2015)
Reactive protein cysteine thiolates are instrumental in redox regulation. Oxidants, such as hydrogen peroxide (H2O2), react with thiolates to form oxidative post-translational modifications, enabling physiological redox signaling. Cardiac disease and
Externí odkaz: https://doaj.org/article/17226e23b1354d9a9df939a220b367f6
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5
Effects of Sodium‐Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice
Autor: Ion A. Hobai, Wilson S. Colucci, Dominique Croteau, Deborah A. Siwik, Jordan M. Chambers, Fuzhong Qin, Marcello Panagia, Ivan Luptak, David R. Pimentel
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Inhibitors of the sodium‐glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are unknown. We assessed the eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16203839faa370c679548b749eaa129
http://europepmc.org/articles/PMC8403324
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6
Abstract 16641: The SGLT2 Inhibitor Ertugliflozin Induces Oxidative Phosphorylation Gene Expression and Improves Systolic Function Independent of Diabetes in Mice
Autor: Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v: Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::745c6cf907599986b5cff1d79bd630c2
https://doi.org/10.1161/circ.142.suppl_3.16641
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7
Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease
Autor: Fuzhong Qin, Deborah A. Siwik, David R. Pimentel, Ivan Luptak, Marcello Panagia, Dominique Croteau, Jordan M. Chambers, Wilson S. Colucci, Ethan Kallick
Publikováno v: JACC. Basic to translational science. 5(9)
Highlights •MHD associated with obesity, diabetes, and/or metabolic syndrome is an important precursor of HFpEF. •Mice fed a HFHS diet develop MHD with myocardial hypertrophy, fibrosis, diastolic dysfunction, and impaired energetics. •Mice on H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860f711e67b12791891a81545cd7f650
https://pubmed.ncbi.nlm.nih.gov/33016957
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8
Energetic Dysfunction Is Mediated by Mitochondrial Reactive Oxygen Species and Precedes Structural Remodeling in Metabolic Heart Disease
Autor: Marcello Panagia, Deborah A. Siwik, James A. Balschi, Fuzhong Qin, Huamei He, David R. Pimentel, Dominique Croteau, Wilson S. Colucci, Markus Bachschmid, Aaron L. Sverdlov, Ivan Luptak
Publikováno v: Antioxid Redox Signal
Aims: Metabolic syndrome is associated with metabolic heart disease (MHD) that is characterized by left ventricular (LV) hypertrophy, interstitial fibrosis, contractile dysfunction, and mitochondrial dysfunction. Overexpression of catalase in mitocho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f22eb1b2eef9b35472d08b4295db58d
https://europepmc.org/articles/PMC6648235/
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9
Galectin‐3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients
Autor: Deborah A. Siwik, Deepa M. Gopal, Wilson S. Colucci, Noyan Gokce, Nir Ayalon, Marcello Panagia, Jill Downing, Chang Seng Liang, Aaron L. Sverdlov, Alejandro J. Perez, Courtney Donohue, Jennifer E. Ho, Vanessa Silva, Yi-Chih Wang, Vijaya B. Kolachalama, Caroline M. Apovian
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high‐risk individuals for heart failure prevention
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f4af6f6b07360528f42f56b1ecd67
http://europepmc.org/articles/PMC6509711
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10
Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis
Autor: Catherine Valentine, Daniel G. Remick, Dominique Croteau, Deborah A. Siwik, Fuzhong Qin, Ivan Luptak, Wilson S. Colucci, Ion A. Hobai
Publikováno v: Shock (Augusta, Ga.). 52(1)
Mice challenged with lipopolysaccharide develop cardiomyopathy in a sex and redox-dependent fashion. Here we extended these studies to the cecal ligation and puncture (CLP) model.We compared male and female FVB mice (wild type, WT) and transgenic lit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e0e04b0e42a0b2a6b0cca68f4b5e5d
https://pubmed.ncbi.nlm.nih.gov/30102640
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