Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Deborah A Shear"'
Autor:
Angela M Boutté, Bharani Thangavelu, Christina R LaValle, Jeffrey Nemes, Janice Gilsdorf, Deborah A Shear, Gary H Kamimori
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221036 (2019)
Repeated exposure to blast overpressure remains a major cause of adverse health for military personnel who, as a consequence, are at a higher risk for neurodegenerative disease and suicide. Acute, early tracking of blast related effects holds the pro
Externí odkaz:
https://doaj.org/article/7b1eb7dfd56f4901ae732112da22512b
Autor:
Casandra M Cartagena, Andrea Mountney, Hye Hwang, Adam Swiercz, Zoe Rammelkamp, Angela M Boutte, Deborah A Shear, Frank C Tortella, Kara E Schmid
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158576 (2016)
Traumatic brain injury (TBI) is an established risk factor for the development of Alzheimer's disease (AD). Here the effects of severe penetrating TBI on APP and tau cleavage processing were investigated in a rodent model of penetrating ballistic-lik
Externí odkaz:
https://doaj.org/article/f5955dc4d5004ea3bd60f6136ab8e2cc
Autor:
Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Starlyn L. Okada-Rising, Zachary S. Bailey, Anke H. Scultetus, Deborah A. Shear
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the greatest obstacle to the successful delivery of drug therapies
Externí odkaz:
https://doaj.org/article/9a79016d0e324d9fae93ac21abf88e5c
Autor:
Hiren R. Modi, Sudeep Musyaju, Meaghan Ratcliffe, Deborah A. Shear, Anke H. Scultetus, Jignesh D. Pandya
Publikováno v:
Antioxidants, Vol 13, Iss 3, p 303 (2024)
Traumatic brain injury (TBI) is a major global health problem that affects both civilian and military populations worldwide. Post-injury acute, sub-acute, and chronic progression of secondary injury processes may contribute further to other neurodege
Externí odkaz:
https://doaj.org/article/a842b4e7f3e1492785c05e8b77a3e358
Autor:
Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Ying Cao, William J. Flerlage, Linda Huynh, Brittany Kociuba, Nishant P. Visavadiya, Firas Kobeissy, Kevin Wang, Janice S. Gilsdorf, Anke H. Scultetus, Deborah A. Shear
Publikováno v:
Free Radical Biology and Medicine. 198:44-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d3cce0ae4cee0b6150f37a03eee8486
https://doi.org/10.1016/j.freeradbiomed.2023.02.001
https://doi.org/10.1016/j.freeradbiomed.2023.02.001
Autor:
Bharani Thangavelu, Bernard S. Wilfred, David Johnson, Janice S. Gilsdorf, Deborah A. Shear, Angela M. Boutté
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Severe traumatic brain injury (TBI) is a risk factor for neurodegenerative diseases. Yet, the molecular events involving dysregulated miRNAs that may be associated with protein degradation in the brain remains elusive. Quantitation of more than 800 m
Externí odkaz:
https://doaj.org/article/ef49138815844e46bb9a8f9cc728a63f
Autor:
Jignesh D. Pandya, Lai Yee Leung, Xiaofang Yang, William J. Flerlage, Janice S. Gilsdorf, Ying Deng-Bryant, Deborah A. Shear
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Mitochondria constitute a central role in brain energy metabolism, and play a pivotal role in the development of secondary pathophysiology and subsequent neuronal cell death following traumatic brain injury (TBI). Under normal circumstances, the brai
Externí odkaz:
https://doaj.org/article/0326c523cc144c7b8948aeff20bd7916
Autor:
Jeremy Henchir, Shaun W. Carlson, Benjamin E Zusman, Zachary S. Bailey, Vincent Vagni, Ruchira M. Jha, Keri Janesko-Feldman, Janice S. Gilsdorf, Patrick M. Kochanek, Deborah A. Shear, C. Edward Dixon
Publikováno v:
J Neurotrauma
Civilian traumatic brain injury (TBI) guidelines recommend resuscitation of patients with hypotensive TBI with crystalloids. Increasing evidence, however, suggests that whole blood (WB) resuscitation may improve physiological and survival outcomes at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6336df15e84e3629001ff01b7cb945a2
https://doi.org/10.1089/neu.2021.0157
https://doi.org/10.1089/neu.2021.0157
Autor:
Xiaofang Yang, Jignesh D. Pandya, Hye Hwang, Ying Deng-Bryant, Lai Yee Leung, Deborah A. Shear
Publikováno v:
Journal of Neurotrauma. 38:2323-2334
Mitochondrial dysfunction is a pivotal target for neuroprotection strategies for traumatic brain injury (TBI). However, comprehensive time-course evaluations of mitochondrial dysfunction are lacking in the pre-clinical penetrating TBI (PTBI) model. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fce5010f4ec7170bacb4cda3004a7a
https://doi.org/10.1089/neu.2020.7379
https://doi.org/10.1089/neu.2020.7379
Autor:
Patrick M. Kochanek, David O. Okonkwo, Vincent Vagni, Ruchira M. Jha, Keri Janesko-Feldman, Zachary S. Bailey, Lori Shutter, Benjamin E Zusman, Ava M. Puccio, Deborah A. Shear, Lai Yee Leung, Janice S. Gilsdorf
Publikováno v:
Neurocrit Care
BACKGROUND: Despite increasing use in hemorrhagic shock (HS), whole blood (WB) resuscitation for polytrauma with traumatic brain injury (TBI) is largely unexplored. Current TBI guidelines recommend crystalloid for prehospital resuscitation. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0040ca905e2b992bb4bf34647ba2568
https://doi.org/10.1007/s12028-020-01084-1
https://doi.org/10.1007/s12028-020-01084-1