Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Deborah A, Schaefer"'
Autor:
Nigel Yarlett, Mary Morada, Deborah A Schaefer, Kevin Ackman, Elizabeth Carranza, Rodrigo de Paula Baptista, Michael W Riggs, Jessica C Kissinger
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011992 (2024)
Recent advances in the in vitro cultivation of Cryptosporidium parvum using hollow fiber bioreactor technology (HFB) have permitted continuous growth of parasites that complete all life cycle stages. The method provides access to all stages of the pa
Externí odkaz:
https://doaj.org/article/0e2fb4f6db3040a782fc7aca4017fc3f
Autor:
Paul Kelly, William A Petri, Rashidul Haque, Ibrahim A Khalil, Lynn Barrett, Tom Kennedy, Timothy Wells, Christopher D Huston, James Platts-mills, Grace S Yang, Richard Omore, Ian H Gilbert, Sumiti Vinayak, Boris Striepen, Ujjini H Manjunatha, Wesley C Van Voorhis, Samuel L M Arnold, Beatriz Baragana, Frederick S Buckner, Jeremy D Burrows, Maria A Caravedo, Ryan Choi, Robert K M Choy, Eugenio de Hostos, Thierry Diagana, Suzanne Duce, Matthew A Hulverson, Pui-Ying Iroh Tam, Minju Kim, Poonum Korpe, Benoît Laleu, Diana Lalika, Fabrice Laurent, Case W McNamara, Marvin J Meyers, Roberta M O’Connor, Kayode K Ojo, Philipp Olias, Nede Ovbiebo, Mattie C Pawlowic, Gladys Queen, Divya Rao, Kevin Reed, Michael W Riggs, Jennifer L Roxas, Adam Sateriale, Deborah A Schaefer, L David Sibley, Jonathan M Spector, Chris Tonkin, Timilehin E Toye, Saul Tzipori, A Clinton White
Publikováno v:
BMJ Global Health, Vol 8, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/540e409047fd43baae051b1737c1bbc5
Autor:
Kelli L. VanDussen, Lisa J. Funkhouser-Jones, Marianna E. Akey, Deborah A. Schaefer, Kevin Ackman, Michael W. Riggs, Thaddeus S. Stappenbeck, L. David Sibley
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT The protozoan parasite Cryptosporidium sp. is a leading cause of diarrheal disease in those with compromised or underdeveloped immune systems, particularly infants and toddlers in resource-poor localities. As an enteric pathogen, Cryptospori
Externí odkaz:
https://doaj.org/article/15ba3df73dfa42048c217995bef69455
Autor:
Roberta M O'Connor, Felix J Nepveux V, Jaypee Abenoja, Gregory Bowden, Patricia Reis, Josiah Beaushaw, Rachel M Bone Relat, Iwona Driskell, Fernanda Gimenez, Michael W Riggs, Deborah A Schaefer, Eric W Schmidt, Zhenjian Lin, Daniel L Distel, Jon Clardy, Timothy R Ramadhar, David R Allred, Heather M Fritz, Pradipsinh Rathod, Laura Chery, John White
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008600 (2020)
Apicomplexan parasites cause severe disease in both humans and their domesticated animals. Since these parasites readily develop drug resistance, development of new, effective drugs to treat infection caused by these parasites is an ongoing challenge
Externí odkaz:
https://doaj.org/article/f409fe1b5c164785aed21bd8fb436bc8
Autor:
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer, Molly C. McCloskey, Grant R. Whitman, Wenlin Huang, Sangun Lee, Andy Pranata, Malcolm D. McLeod, Kennan C. Marsh, Dale J. Kempf, Bruce E. LeRoy, Mark T. Zafiratos, Aimee L. Bielinski, Robert C. Hackman, Kayode K. Ojo, Samuel L. M. Arnold, Lynn K. Barrett, Saul Tzipori, Michael W. Riggs, Erkang Fan, Wesley C. Van Voorhis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety
Autor:
Wesley C. Van Voorhis, Ashley K. Woods, Melissa S. Love, Deborah A. Schaefer, Sean B. Joseph, Samuel L.M. Arnold, Victor Chi, Michael W. Riggs, Cindy X. Zhang, Pui Ying Iroh Tam, Case W. McNamara, Dana P. Betzer
Publikováno v:
Antimicrobial Agents and Chemotherapy
Infection with Cryptosporidium spp. can cause severe diarrhea, leading to long-term adverse impacts and even death in malnourished children and immunocompromised patients. The only FDA-approved drug for treating cryptosporidiosis, nitazoxanide, has l
Autor:
Michael W. Riggs, Marianna E. Akey, Thaddeus S. Stappenbeck, Kevin Ackman, Deborah A. Schaefer, Kelli L. VanDussen, Lisa J. Funkhouser-Jones, L. David Sibley
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
mBio
mBio
Cryptosporidium sp. occupies a unique intracellular niche that exposes the parasite to both host cell contents and the intestinal lumen, including metabolites from the diet and produced by the microbiota. Both dietary and microbial products change ov
Autor:
Karine Thivierge, Sophie Cotton, Deborah A Schaefer, Michael W Riggs, Joyce To, Maria E Lund, Mark W Robinson, John P Dalton, Sheila M Donnelly
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 7, p e2307 (2013)
Host defence peptides (HDPs) are expressed throughout the animal and plant kingdoms. They have multifunctional roles in the defence against infectious agents of mammals, possessing both bactericidal and immune-modulatory activities. We have identifie
Externí odkaz:
https://doaj.org/article/587082dbfc67421e9a3a68cef47a272f
Autor:
Dennis Imhof, Kayode K. Ojo, Pablo Winzer, Joachim Müller, Samuel L.M. Arnold, Lynn K. Barrett, Thomas J. Kennedy, J. Stone Doggett, Nicoleta Anghel, Deborah A. Schaefer, Sangun Lee, Saul Tzipori, Wesley C. Van Voorhis, Roberto Sánchez-Sánchez, Grant R. Whitman, Luis Miguel Ortega-Mora, Ignacio Ferre, Wenlin Huang, Andrew Hemphill, Dustin J. Maly, Rama Subba Rao Vidadala, Michael W. Riggs, Erkang Fan, Matthew A. Hulverson, Ryan Choi, Dana P. Betzer
Publikováno v:
Vet Parasitol
This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, a
Autor:
Kevin Ackman, Marianna E. Akey, Lisa J. Funkhouser-Jones, Michael W. Riggs, L. David Sibley, Kelli L. VanDussen, Thaddeus S. Stappenbeck, Deborah A. Schaefer
The protozoan parasite Cryptosporidium is a leading cause of diarrheal disease in those with compromised or under-developed immune systems, particularly infants and toddlers in resource-poor localities. As an enteric pathogen, Cryptosporidium invades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c009226d30a1b8c70f3098f275d2e48
https://doi.org/10.1101/2020.09.11.294462
https://doi.org/10.1101/2020.09.11.294462