Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Deborah A, Hogan"'
Autor:
Yu-Ying Phoebe Hsieh, Wanting Sun, Janet M Young, Robin Cheung, Deborah A Hogan, Ajai A Dandekar, Harmit S Malik
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002694 (2024)
Fungi and bacteria coexist in many polymicrobial communities, yet the molecular basis of their interactions remains poorly understood. Here, we show that the fungus Candida albicans sequesters essential magnesium ions from the bacterium Pseudomonas a
Externí odkaz:
https://doaj.org/article/2a21b5d9164a439aa58deebd1547c39b
Autor:
Jaime de Anda, Sherry L. Kuchma, Shanice S. Webster, Arman Boromand, Kimberley A. Lewis, Calvin K. Lee, Maria Contreras, Victor F. Medeiros Pereira, William Schmidt, Deborah A. Hogan, Corey S. O’Hern, George A. O’Toole, Gerard C. L. Wong
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSwarming is a macroscopic phenomenon in which surface bacteria organize into a motile population. The flagellar motor that drives swarming in Pseudomonas aeruginosa is powered by stators MotAB and MotCD. Deletion of the MotCD stator eliminate
Externí odkaz:
https://doaj.org/article/391efbc41e544b3484677d31ac9c0f1a
Pseudomonas aeruginosa transcriptome analysis of metal restriction in ex vivo cystic fibrosis sputum
Autor:
Samuel L. Neff, Georgia Doing, Taylor Reiter, Thomas H. Hampton, Casey S. Greene, Deborah A. Hogan
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTChronic Pseudomonas aeruginosa lung infections are a feature of cystic fibrosis (CF) that many patients experience even with the advent of highly effective modulator therapies. Identifying factors that impact P. aeruginosa in the CF lung coul
Externí odkaz:
https://doaj.org/article/032883e619794fcf91a52e4e813277fd
Autor:
Daniel S. Aridgides, Diane L. Mellinger, Lorraine L. Gwilt, Thomas H. Hampton, Dallas L. Mould, Deborah A. Hogan, Alix Ashare
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Macrophage dysfunction has been well-described in Cystic Fibrosis (CF) and may contribute to bacterial persistence in the lung. Whether CF macrophage dysfunction is related directly to Cystic Fibrosis Transmembrane Conductance Regulator (CFT
Externí odkaz:
https://doaj.org/article/3499643d88e04029a4169251b68131a1
Autor:
Dallas L. Mould, Carson E. Finger, Amy Conaway, Nico Botelho, Stacie E. Stuut, Deborah A. Hogan
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Cross-feeding of metabolites between subpopulations can affect cell phenotypes and population-level behaviors. In chronic Pseudomonas aeruginosa lung infections, subpopulations with loss-of-function (LOF) mutations in the lasR gene are commo
Externí odkaz:
https://doaj.org/article/7b06231ec274467daf202ffb221434dc
Autor:
Alexandra J. Lee, Dallas L. Mould, Jake Crawford, Dongbo Hu, Rani K. Powers, Georgia Doing, James C. Costello, Deborah A. Hogan, Casey S. Greene
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 5, Pp 912-927 (2022)
Genome-wide transcriptome profiling identifies genes that are prone to differential expression (DE) across contexts, as well as genes with changes specific to the experimental manipulation. Distinguishing genes that are specifically changed in a cont
Externí odkaz:
https://doaj.org/article/23d39b95a13b4a23a60211c9d4fe3a5c
Autor:
Daniel Murante, Elora G. Demers, Tania Kurbessoian, Marina Ruzic, Alix Ashare, Jason E. Stajich, Deborah A. Hogan
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT The genetic disease cystic fibrosis (CF) frequently leads to chronic lung infections by bacteria and fungi. We identified three individuals with CF with persistent lung infections dominated by Clavispora (Candida) lusitaniae. Whole-genome se
Externí odkaz:
https://doaj.org/article/18e559cb80e945ca80435c991c77423b
Autor:
Samuel L. Neff, Thomas H. Hampton, Charles Puerner, Liviu Cengher, Georgia Doing, Alexandra J. Lee, Katja Koeppen, Ambrose L. Cheung, Deborah A. Hogan, Robert A. Cramer, Bruce A. Stanton
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-14 (2022)
Abstract Researchers studying cystic fibrosis (CF) pathogens have produced numerous RNA-seq datasets which are available in the gene expression omnibus (GEO). Although these studies are publicly available, substantial computational expertise and manu
Externí odkaz:
https://doaj.org/article/5e30a2f3c1034ab18bf4061492bd63f8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4315-4324 (2022)
A gene expression compendium is a heterogeneous collection of gene expression experiments assembled from data collected for diverse purposes. The widely varied experimental conditions and genetic backgrounds across samples creates a tremendous opport
Externí odkaz:
https://doaj.org/article/ed93e0f2f99d46178b55729cbfa7c480
Autor:
Georgia Doing, Alexandra J. Lee, Samuel L. Neff, Taylor Reiter, Jacob D. Holt, Bruce A. Stanton, Casey S. Greene, Deborah A. Hogan
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT Thousands of Pseudomonas aeruginosa RNA sequencing (RNA-seq) gene expression profiles are publicly available via the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA). In this work, the transcriptional profiles
Externí odkaz:
https://doaj.org/article/88e2643156ae4b42b1d30edcecf0e6c2