Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Deborah Stanford"'
Autor:
Pierre Lafite, Stephen E. J. Rigby, Deborah Stanford, Steven R. Rossington, David Leys, Marie Goldrick, Ian Roberts, Andrew V. Stachulski, Derren J. Heyes, Colin Levy, Nigel S. Scrutton
Publikováno v:
Journal of Biological Chemistry. 284:35514-35523
The enzyme CMP-Kdo synthetase (KdsB) catalyzes the addition of 2-keto-3-deoxymanno-octulonic acid (Kdo) to CTP to form CMP-Kdo, a key reaction in the biosynthesis of lipopolysaccharide. The reaction catalyzed by KdsB and the related CMP-acylneuramina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9f16df9e9dcff6d0aca4c090dd90ef
https://doi.org/10.1074/jbc.m109.056630
https://doi.org/10.1074/jbc.m109.056630
Autor:
Stephen Hindley, Paul M. O'Neill, Eghbaleh Asadollahy, Karen Rimmer, Alison E. Shone, Gemma L. Nixon, James L. Maggs, Stephen A. Ward, Richard A. Brigandi, Martin Bates, Patrick G. Bray, P. A. Winstanley, Paul A. Stocks, Jill Davies, Silvia Parapini, Livia Vivas, Domingo Gargallo, Stephanie L. Gresham, Hollie Lander, Giancarlo A. Biagini, B. Kevin Park, Donatella Taramelli, Ramesh Bambal, Federico M. Gomez-de-las-Heras, Charles B. Davis, Charlotte Hall, Neil G. Berry, Phil Roberts, Deborah Stanford
Publikováno v:
Journal of Medicinal Chemistry. 52:1828-1844
On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-aminophenol "metabolic alert" has been modified by replacement of the 4'-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2075934bbaca76abf6a07eb93897a
https://doi.org/10.1021/jm8012757
https://doi.org/10.1021/jm8012757
Autor:
María Jesús, Gemma L. Ellis, Livia Vivas, Jill Davies, Emily Bongard, Alison E. Shone, Domingo Gargallo, Sarah C. Charnaud, Karen Rimmer, Richard Amewu, Paul M. O'Neill, Sunil Sabbani, Deborah Stanford, Peter Gibbons, Stephen A. Ward, Paul A. Stocks, Sonia Lozanom, Charlotte Hall
Publikováno v:
Journal of Medicinal Chemistry. 51:2170-2177
A rapid, two-step synthesis of a range of dispiro-1,2,4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior to 1,2,4-trioxolanes in terms of stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030b9ed2f11ed04356cc9e1c48588770
https://doi.org/10.1021/jm701435h
https://doi.org/10.1021/jm701435h
Autor:
Deborah Stanford, Andrew V. Stachulski
Publikováno v:
Tetrahedron Letters. 48:2361-2364
One of the characteristic reactions of glucuronic acid derivatives is the base-catalysed elimination of a 4-(substituted) hydroxy group to generate a Δ4,5 pyranose. Following hydrogenation, proceeding mainly from the α-face provided the anomeric co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::346efd8018a819d6f1e4e284dbdbbc56
https://doi.org/10.1016/j.tetlet.2007.01.127
https://doi.org/10.1016/j.tetlet.2007.01.127
Autor:
Derren J, Heyes, Colin, Levy, Pierre, Lafite, Ian S, Roberts, Marie, Goldrick, Andrew V, Stachulski, Steven B, Rossington, Deborah, Stanford, Stephen E J, Rigby, Nigel S, Scrutton, David, Leys
Publikováno v:
The Journal of biological chemistry. 284(51)
The enzyme CMP-Kdo synthetase (KdsB) catalyzes the addition of 2-keto-3-deoxymanno-octulonic acid (Kdo) to CTP to form CMP-Kdo, a key reaction in the biosynthesis of lipopolysaccharide. The reaction catalyzed by KdsB and the related CMP-acylneuramina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad751422a9d2155221cafed80a652dd8
https://pubmed.ncbi.nlm.nih.gov/19815542
https://pubmed.ncbi.nlm.nih.gov/19815542
Autor:
Paul M. O’Neill, Alison E. Shone, Deborah Stanford, Gemma Nixon, Eghbaleh Asadollahy, B. Kevin Park, James L. Maggs, Phil Roberts, Paul A. Stocks, Giancarlo Biagini, Patrick G. Bray, Jill Davies, Neil Berry, Charlotte Hall, Karen Rimmer, Peter A. Winstanley, Stephen Hindley, Ramesh B. Bambal, Charles B. Davis, Martin Bates
Publikováno v:
Journal of Medicinal Chemistry; Apr2009, Vol. 52 Issue 7, p1828-1844, 17p
Autor:
Gemma L. Ellis, Richard Amewu, Sunil Sabbani, Paul A. Stocks, Alison Shone, Deborah Stanford, Peter Gibbons, Jill Davies, Livia Vivas, Sarah Charnaud, Emily Bongard, Charlotte Hall, Karen Rimmer, Sonia Lozanom, María Jesús, Domingo Gargallo, Stephen A. Ward, Paul M. O’Neill
Publikováno v:
Journal of Medicinal Chemistry; Mar2008, Vol. 51 Issue 7, p2170-2177, 8p