Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells

Autor: Aafke W. F. Janssen, Wendy Jansen Holleboom, Deborah Rijkers, Jochem Louisse, Sjoerdtje A. Hoekstra, Sanne Schild, Misha F. Vrolijk, Ron L. A. P. Hoogenboom, Karsten Beekmann

Publikováno v: Frontiers in Toxicology, Vol 6 (2024)

Exposure to PFASs is associated to several adverse health effects, such as immunotoxicity. Immunotoxic effects of PFOA and PFOS, including a reduced antibody response in both experimental animals and humans, have been reported. However, there is limi

Externí odkaz: https://doaj.org/article/1fdaed18e8dc44ae98f85dd2c4aeab56

Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

Autor: Jochem Louisse, Luca Dellafiora, Jeroen J. M. W. van den Heuvel, Deborah Rijkers, Liz Leenders, Jean-Lou C. M. Dorne, Ans Punt, Frans G. M. Russel, Jan B. Koenderink

Publikováno v: Archives of Toxicology, 97, 3, pp. 685-696
Archives of Toxicology 97 (2023) 3
Archives of Toxicology, 97(3), 685-696
Archives of Toxicology, 97, 685-696

Contains fulltext : 291310.pdf (Publisher’s version ) (Open Access) Poly- and perfluoroalkyl substances (PFASs) are omnipresent in the environment and have been shown to accumulate in humans. Most PFASs are not biotransformed in animals and humans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a27e391e6bed55ba30277471e5341f
https://hdl.handle.net/2066/291310

Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells

Autor: Jochem Louisse, Styliani Fragki, Deborah Rijkers, Aafke Janssen, Bas van Dijk, Liz Leenders, Martijn Staats, Bas Bokkers, Marco Zeilmaker, Aldert Piersma, Mirjam Luijten, Ron Hoogenboom, Ad Peijnenburg

Publikováno v: Archives of Toxicology 97 (2023) 4
Archives of Toxicology, 97(4), 1113-1131

Per- and polyfluoroalkyl substances (PFASs) are omnipresent and have been shown to induce a wide range of adverse health effects, including hepatotoxicity, developmental toxicity, and immunotoxicity. The aim of the present work was to assess whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8859491c25eb20ddd224dd6229a00df5
https://research.wur.nl/en/publications/determination-of-in-vitro-hepatotoxic-potencies-of-a-series-of-pe

New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs

Autor: Styliani Fragki, Jochem Louisse, Bas Bokkers, Mirjam Luijten, Ad Peijnenburg, Deborah Rijkers, Aldert H. Piersma, Marco J. Zeilmaker

Publikováno v: Food and Chemical Toxicology, 172
Food and Chemical Toxicology 172 (2023)

Per: and polyfluoroalkyl substances (PFASs) have been associated with increased blood lipids in humans. Perfluorooctanoic acid (PFOA) has been also linked with elevated alanine transferase (ALT) serum levels in humans, and in rodents the liver is a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0a41c86adc2f070aaa2f07f7d1a82
https://pubmed.ncbi.nlm.nih.gov/36535450

Bioassay-directed analysis-based identification of relevant pyrrolizidine alkaloids

Autor: Jochem Louisse, Patrick P. J. Mulder, Arjen Gerssen, Geert Stoopen, Deborah Rijkers, Milou G. M. van de Schans, Ad A. C. M. Peijnenburg

Publikováno v: Archives of Toxicology 96 (2022) 8
Archives of Toxicology, 96(8), 2299-2317

Pyrrolizidine alkaloids (PAs) are produced by various plant species and have been detected as contaminants in food and feed. Monitoring programmes should include PAs that are present in relevant matrices and that exhibit a high toxic potential. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1a7aa2e45031d8728edbbbed7cd66c
https://research.wur.nl/en/publications/bioassay-directed-analysis-based-identification-of-relevant-pyrro