Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Deborah, Needham"'
Autor:
Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe
Publikováno v:
Journal of Medicinal Chemistry. 65:633-664
The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe asthma, and there is emerging interest in the development of small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765
https://doi.org/10.1021/acs.jmedchem.1c01765
Autor:
Deborah Needham, Jason A. Holt, Stuart N. Farrow, Robert J. H. Austin, Keith Biggadike, Karen Leavens, Iain Uings, Davina C. Angell, Michael V. Haase, Joyce Lesley Matthews
Publikováno v:
British Journal of Pharmacology. 169:1389-1403
Background and Purpose Glucocorticoids are highly effective therapies for a range of inflammatory diseases. Advances in the understanding of the diverse molecular mechanisms underpinning glucocorticoid action suggest that anti-inflammatory molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25957fdf79777640947506765da7aa8d
https://doi.org/10.1111/bph.12232
https://doi.org/10.1111/bph.12232
Autor:
Rebecca H. Graves, Alan P. Hill, David E. Clapham, Steven L. Sollis, Karen M. L. Morriss, Robert J. Slack, Nick Barton, Ashley Paul Hancock, Heather Hobbs, Afjal Hussain Miah, Coline Jumeaux, Alison J. Ford, Claire E. Smith, Deborah Needham, Emma B. Sheriff, Panayiotis A. Procopiou, Simon Teanby Hodgson, John Barrett, Malcolm Begg, David A. Hall, Yannick M. L. Lacroix, Royston C. B. Copley, Hugo Staton
Publikováno v:
Journal of Medicinal Chemistry. 56:1946-1960
A series of indazole arylsulfonamides were synthesized and examined as human CCR4 antagonists. Methoxy- or hydroxyl-containing groups were the more potent indazole C4 substituents. Only small groups were tolerated at C5, C6, or C7, with the C6 analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae8d8293ba0da5bc006f2fa7aeae3c0
https://doi.org/10.1021/jm301572h
https://doi.org/10.1021/jm301572h
Autor:
David A. Hall, Yannick M. L. Lacroix, Alison J. Ford, Deborah Needham, Rebecca H. Graves, Robert J. Slack, Panayiotis A. Procopiou, Simon Teanby Hodgson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2730-2733
Synthesis and preliminary SAR of the N1 substituent of a novel series of indazole sulfonamide chemokine receptor 4 (CCR4) antagonist is reported. Compound 7r was identified for further development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5236d775d1e575285ec5ad4362f26615
https://doi.org/10.1016/j.bmcl.2012.02.104
https://doi.org/10.1016/j.bmcl.2012.02.104
Autor:
Brian Edgar Looker, Victoria J. Barrett, Gillian Elizabeth Lunniss, Alison J. Ford, Claire E. Smith, Deborah Needham, Panayiotis A. Procopiou, Graham Somers
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6026-6032
A series of novel, potent and selective human β(2) adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (R)-salmeterol is presented. Urea 9j had long duration of action in vitro on guinea pig trachea, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91e221aaa9c98f2551bc2de2aa19efaa
https://doi.org/10.1016/j.bmc.2011.08.043
https://doi.org/10.1016/j.bmc.2011.08.043
Autor:
Simon J. F. Macdonald, Philip Alan Skone, Ian B. Campbell, Diane M. Coe, Tony W. J. Cooper, Gordon A. Weingarten, Peter W. Sutton, Deborah Needham, George Hardy, Tracy Jane Shipley, Haydn Terence Jones, Torquil I. Jack, Steven Philip Keeling
Publikováno v:
Tetrahedron Letters. 49:5101-5104
The efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide is reported. This highly versatile building block may be reacted sequentially with two different nucleophiles to furnish α-trifluoromethyl tertiary alcohols. Furthermore, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39e5ddf37cef54e5d27b966049701f90
https://doi.org/10.1016/j.tetlet.2008.06.011
https://doi.org/10.1016/j.tetlet.2008.06.011
Autor:
Juan D, Guzman, Thomas, Pesnot, Diana A, Barrera, Heledd M, Davies, Eleanor, McMahon, Dimitrios, Evangelopoulos, Parisa N, Mortazavi, Tulika, Munshi, Arundhati, Maitra, Eleanor D, Lamming, Richard, Angell, Markus C, Gershater, Joanna M, Redmond, Deborah, Needham, John M, Ward, Luis E, Cuca, Helen C, Hailes, Sanjib, Bhakta
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv. A biomimetic approach for the chemical synthesis of a wide array of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd75de37533da277f55bfab44e8a25c1
https://pubmed.ncbi.nlm.nih.gov/25656411
https://pubmed.ncbi.nlm.nih.gov/25656411
Autor:
Peter R. Butchers, Victoria J. Barrett, Peter J. Mutch, Andrew P. Craven, Sara C Hughes, Mark Ruston, Duncan S. Holmes, Alison J. Ford, Keith Biggadike, Brian Edgar Looker, Stephen Barry Guntrip, Anne Jones, Deborah Needham, Panayiotis A. Procopiou, Claire E. Smith
Publikováno v:
Journal of medicinal chemistry. 57(1)
A series of novel, potent, and selective human β2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ring of (R)-salmeterol is presented. Sulfone 10b had salmeterol-like potency and selectivity profile, long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b6472cee081248047681c7f3def8d6
https://pubmed.ncbi.nlm.nih.gov/24359185
https://pubmed.ncbi.nlm.nih.gov/24359185
Autor:
Simon Teanby Hodgson, Yannick M. L. Lacroix, Robert J. Slack, Deborah Needham, Rebecca H. Graves, Panayiotis A. Procopiou, David A. Hall, Alison J. Ford
Publikováno v:
ChemInform. 43
Compound (Id) is identified for further development within a novel series of indazole sulfonamide chemokine receptor 4 (CCR4) antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453037d5babcacee0da7c82541905355
https://doi.org/10.1002/chin.201235127
https://doi.org/10.1002/chin.201235127
Autor:
Panayiotis A, Procopiou, Victoria J, Barrett, Alison J, Ford, Brian E, Looker, Gillian E, Lunniss, Deborah, Needham, Claire E, Smith, Graham, Somers
Publikováno v:
Bioorganicmedicinal chemistry. 19(20)
A series of novel, potent and selective human β(2) adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (R)-salmeterol is presented. Urea 9j had long duration of action in vitro on guinea pig trachea, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f25ea3f11a7ebe78d8988ec29e874a07
https://pubmed.ncbi.nlm.nih.gov/21925889
https://pubmed.ncbi.nlm.nih.gov/21925889