Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Deborah, DeRyckere"'
Autor:
Hope L. Mumme, Sunil S. Raikar, Swati S. Bhasin, Beena E. Thomas, Taylor Lawrence, Elizabeth P. Weinzierl, Yakun Pang, Deborah DeRyckere, Chuck Gawad, Daniel S. Wechsler, Christopher C. Porter, Sharon M. Castellino, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)
Abstract Background Mixed phenotype acute leukemia (MPAL), a rare subgroup of leukemia characterized by blast cells with myeloid and lymphoid lineage features, is difficult to diagnose and treat. A better characterization of MPAL is essential to unde
Externí odkaz:
https://doaj.org/article/27b0d44d90b644919eac2539e49cde72
Autor:
Hope Mumme, Beena E. Thomas, Swati S. Bhasin, Upaasana Krishnan, Bhakti Dwivedi, Pruthvi Perumalla, Debasree Sarkar, Gulay B. Ulukaya, Himalee S. Sabnis, Sunita I. Park, Deborah DeRyckere, Sunil S. Raikar, Melinda Pauly, Ryan J. Summers, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to analyze pediatric AML bone marrow (BM) samples from diagnosis (Dx),
Externí odkaz:
https://doaj.org/article/a3787863b5cb43ff9dcb50ae8a436b4d
Autor:
Swati S. Bhasin, Beena E. Thomas, Ryan J. Summers, Debasree Sarkar, Hope Mumme, William Pilcher, Mohamed Emam, Sunil S. Raikar, Sunita I. Park, Sharon M. Castellino, Douglas K. Graham, Manoj K. Bhasin, Deborah DeRyckere
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Different driver mutations and/or chromosomal aberrations and dysregulated signaling interactions between leukemia cells and the immune microenvironment have been implicated in the development of T-cell acute lymphoblastic leukemia (T-ALL).
Externí odkaz:
https://doaj.org/article/bad7ef4e0fc14a73bb94f1c5d3d5576c
Autor:
Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Obesity has been reported to promote tumourigenesis and chemoresistance but the underlying mechanisms are not completely understood. Here, the authors show that adipocytes induce Galectin-9 (GAL-9) expression in B-acute lymphoblastic leukaemia (B-ALL
Externí odkaz:
https://doaj.org/article/2dbae7c4d3ee43d79487bfe5ab1bc1e6
Autor:
Dan Yan, Justus M. Huelse, Dmitri Kireev, Zikang Tan, Luxiao Chen, Subir Goyal, Xiaodong Wang, Stephen V. Frye, Madhusmita Behera, Frank Schneider, Suresh S. Ramalingam, Taofeek Owonikoko, H. Shelton Earp, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Acquired resistance is inevitable in non–small cell lung cancers (NSCLCs) treated with osimertinib (OSI), and the mechanisms are not well defined. The MERTK ligand GAS6 promoted downstream oncogenic signaling in EGFR-mutated (EGFRMT) NSCLC cells tr
Externí odkaz:
https://doaj.org/article/dc8fcbaf4b6443d0b3ac710d3a2feecb
Autor:
Kavita Dhodapkar, Julie R Gilbert, Himalee S Sabnis, Roman Radzievski, Deon B Doxie, Deborah DeRyckere, Sharon M Castellino
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/ce0a80d48266449f9d276c20d57d644e
Autor:
Alisa B. Lee-Sherick, Kristen M. Jacobsen, Curtis J. Henry, Madeline G. Huey, Rebecca E. Parker, Lauren S. Page, Amanda A. Hill, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Craig T. Jordan, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Externí odkaz:
https://doaj.org/article/1697272d99124244a315c31b3901c007
Autor:
Jithendra Kini Bailur, Samuel S. McCachren, Katherine Pendleton, Juan C. Vasquez, Hong Seo Lim, Alyssa Duffy, Deon B. Doxie, Akhilesh Kaushal, Connor Foster, Deborah DeRyckere, Sharon Castellino, Melissa L. Kemp, Peng Qiu, Madhav V. Dhodapkar, Kavita M. Dhodapkar
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Current management of childhood leukemia is tailored based on disease risk determined by clinical features at presentation. Whether properties of the host immune response impact disease risk and outcome is not known. Here, we combine mass cytometry,
Externí odkaz:
https://doaj.org/article/0fb79d513f1749a48537c85234f76e59
Autor:
Douglas K. Graham, Deborah DeRyckere, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, S. Gail Eckhardt, Tal Burstyn-Cohen, Rotem Kami, William A. Robinson, Stacey M. Bagby, Jacqueline Carrico, John J. Tentler, Katherine A. Minson, Lenka Sinik
Supplemental Figure 3 shows impact of UNC2025 on cell viability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539ee40d58bff3838b818555a378ef59
https://doi.org/10.1158/1535-7163.22508881
https://doi.org/10.1158/1535-7163.22508881
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Deborah DeRyckere, Dehui Zhang, Gregory D. Kirkpatrick, Kurtis D. Davies, Weihe Zhang, Christopher T. Cummings
Treatment of non–small cell lung cancer (NSCLC) has been transformed by targeted therapies directed against molecular aberrations specifically activated within an individual patient's tumor. However, such therapies are currently only available agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd995eb1cfb771d19c0dd97ea5b7f72
https://doi.org/10.1158/1535-7163.c.6536829.v1
https://doi.org/10.1158/1535-7163.c.6536829.v1