Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Debora Soncini"'
Autor:
Eugenio Morelli, Zachary R. Hunter, Mariateresa Fulciniti, Annamaria Gullà, Ida Daniela Perrotta, Valeria Zuccalà, Cinzia Federico, Giada Juli, Martina Manzoni, Domenica Ronchetti, Enrica Romeo, Maria Eugenia Gallo Cantafio, Debora Soncini, Lorenza Maltese, Marco Rossi, Aldo M. Roccaro, Michele Cea, Pierfrancesco Tassone, Antonino Neri, Steven C. Treon, Nikhil C. Munshi, Giuseppe Viglietto, Nicola Amodio
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-6 (2022)
Abstract Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of human diseases including cancer. Here, we show that GPER1 is significantly upregulated in tumor cells from different coh
Externí odkaz:
https://doaj.org/article/8e2f2cc9b27d46db8aa9ce4fa5663b16
Autor:
Cecilia Astigiano, Francesco Piacente, Maria Elena Laugieri, Andrea Benzi, Christian A. Di Buduo, Carolina P. Miguel, Debora Soncini, Michele Cea, Antonella Antonelli, Mauro Magnani, Alessandra Balduini, Antonio De Flora, Santina Bruzzone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6759 (2023)
Sirtuin 6 (SIRT6) is a member of the mammalian NAD+-dependent deac(et)ylase sirtuin family. SIRT6’s anti-inflammatory roles are emerging increasingly often in different diseases and cell types, including endothelial cells. In this study, the role o
Externí odkaz:
https://doaj.org/article/9aea6083f9c84c3b9c7ccede3d20014f
Autor:
Pamela Becherini, Debora Soncini, Silvia Ravera, Elisa Gelli, Claudia Martinuzzi, Giulia Giorgetti, Antonia Cagnetta, Fabio Guolo, Federico Ivaldi, Maurizio Miglino, Sara Aquino, Katia Todoerti, Antonino Neri, Andrea Benzi, Mario Passalacqua, Alessio Nencioni, Ida Perrotta, Maria Eugenia Gallo Cantafio, Nicola Amodio, Antonio De Flora, Santina Bruzzone, Roberto M. Lemoli, Michele Cea
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 494 (2023)
Cancer cells fuel growth and energy demands by increasing their NAD+ biosynthesis dependency, which therefore represents an exploitable vulnerability for anti-cancer strategies. CD38 is a NAD+-degrading enzyme that has become crucial for anti-MM ther
Externí odkaz:
https://doaj.org/article/0e796c050e73475a981a9b6091ebf662
Autor:
Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Identification of novel vulnerabilities in the context of therapeutic resistance is emerging as a key challenge for cancer treatment. Recent studies have detected pervasive aberrant splicing in cancer cells, supporting its targeting for novel therape
Externí odkaz:
https://doaj.org/article/309434a4c8104d54bfdbb57fcf74b015
Autor:
Debora Soncini, Stefania Orecchioni, Samantha Ruberti, Paola Minetto, Claudia Martinuzzi, Luca Agnelli, Katia Todoerti, Antonia Cagnetta, Maurizio Miglino, Marino Clavio, Paola Contini, Riccardo Varaldo, Micaela Bergamaschi, Fabio Guolo, Mario Passalacqua, Alessio Nencioni, Fiammetta Monacelli, Marco Gobbi, Antonino Neri, Giovanni Abbadessa, Sudharshan Eathiraj, Brian Schwartz, Francesco Bertolini, Roberto M. Lemoli, Michele Cea
Publikováno v:
Haematologica, Vol 105, Iss 10 (2019)
Tyrosine kinases have been implicated in promoting tumorigenesis of several human cancers. Exploiting these vulnerabilities has been shown to be an effective anti-tumor strategy as demonstrated for example by the Bruton's tyrosine kinase (BTK) inhibi
Externí odkaz:
https://doaj.org/article/9164c21af1034b3d9449845503413d8d
Autor:
Antonia Cagnetta, Debora Soncini, Stefania Orecchioni, Giovanna Talarico, Paola Minetto, Fabio Guolo, Veronica Retali, Nicoletta Colombo, Enrico Carminati, Marino Clavio, Maurizio Miglino, Micaela Bergamaschi, Aimable Nahimana, Michel Duchosal, Katia Todoerti, Antonino Neri, Mario Passalacqua, Santina Bruzzone, Alessio Nencioni, Francesco Bertolini, Marco Gobbi, Roberto M. Lemoli, Michele Cea
Publikováno v:
Haematologica, Vol 103, Iss 1 (2018)
Genomic instability plays a pathological role in various malignancies, including acute myeloid leukemia (AML), and thus represents a potential therapeutic target. Recent studies demonstrate that SIRT6, a NAD+-dependent nuclear deacetylase, functions
Externí odkaz:
https://doaj.org/article/47f8604720224f48a3eef275ad4a6f41
Autor:
Michele Cea, Debora Soncini, Floriana Fruscione, Lizzia Raffaghello, Anna Garuti, Laura Emionite, Eva Moran, Mirko Magnone, Gabriele Zoppoli, Daniele Reverberi, Irene Caffa, Annalisa Salis, Antonia Cagnetta, Micaela Bergamaschi, Salvatore Casciaro, Ivana Pierri, Gianluca Damonte, Filippo Ansaldi, Marco Gobbi, Vito Pistoia, Alberto Ballestrero, Franco Patrone, Santina Bruzzone, Alessio Nencioni
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22739 (2011)
Aberrant histone deacetylase (HDAC) activity is frequent in human leukemias. However, while classical, NAD(+)-independent HDACs are an established therapeutic target, the relevance of NAD(+)-dependent HDACs (sirtuins) in leukemia treatment remains un
Externí odkaz:
https://doaj.org/article/062b8d15ac464dd1a91dcf9b866139d6
Autor:
Alessio Nencioni, Michele Cea, Anna Garuti, Mario Passalacqua, Lizzia Raffaghello, Debora Soncini, Eva Moran, Gabriele Zoppoli, Vito Pistoia, Franco Patrone, Alberto Ballestrero
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9024 (2010)
The efficacy of anti-HER2 therapeutics, such as lapatinib and trastuzumab, is limited by primary and acquired resistance. Cellular adaptations that allow breast cancer cell to survive prolonged HER2 inhibition include de-repression of the transcripti
Externí odkaz:
https://doaj.org/article/7d9f8ce19fdb4706b9032e36d0ae3cce
Autor:
Santina Bruzzone, Floriana Fruscione, Sara Morando, Tiziana Ferrando, Alessandro Poggi, Anna Garuti, Agustina D'Urso, Martina Selmo, Federica Benvenuto, Michele Cea, Gabriele Zoppoli, Eva Moran, Debora Soncini, Alberto Ballestrero, Bernard Sordat, Franco Patrone, Raul Mostoslavsky, Antonio Uccelli, Alessio Nencioni
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7897 (2009)
Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on prelimin
Externí odkaz:
https://doaj.org/article/41d5255f09ab4955a893904a279a031d
Autor:
Kenneth C. Anderson, Steven P. Treon, Nikhil Munshi, Roberto M. Lemoli, Marco Gobbi, Dharminder Chauhan, Teru Hideshima, Alberto Ballestrero, Fiammetta Monacelli, Fabrizio Montecucco, Alessio Nencioni, Luca Mastracci, Giulio Fraternali-Orcioni, Maurizio Miglino, Debora Soncini, Davide Lovera, Cao Yang, Yu-Tzu Tai, Prakrati Acharya, Chirag Acharya, Antonia Cagnetta, Michele Cea
Suppl. Fig.1. Nampt staining on normal Lymph Nodes; Suppl. Fig. 2. Nampt over-expression in BCMW.1 cells. Suppl. Fig. 3. Dose-response effect curves of FK866; Suppl. Fig. 4. Expression levels of Nampt in WM cells after BTK inhibition (GSE65816); Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4854b5d3413c40465a830b5b231a5413
https://doi.org/10.1158/1078-0432.22467756
https://doi.org/10.1158/1078-0432.22467756
