Výsledky vyhledávání - "Debora Rubio-Aparicio"

Intrinsic Antibacterial Activity of Xeruborbactam

Autor: Dongxu, Sun, Ruslan, Tsivkovski, Joe, Pogliano, Hannah, Tsunemoto, Kirk, Nelson, Debora, Rubio-Aparicio, Olga, Lomovskaya

Publikováno v: Antimicrobial agents and chemotherapy. 66(10)

Xeruborbactam (formerly QPX7728) is a cyclic boronate inhibitor of numerous serine and metallo-beta-lactamases. At concentrations generally higher than those required for beta-lactamase inhibition, xeruborbactam has direct antibacterial activity agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9752c54a8080f4ae679e65bb7031fccf
https://pubmed.ncbi.nlm.nih.gov/36102663

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Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

Autor: Olga Lomovskaya, Maxim Totrov, Dongxu Sun, K. Raja Reddy, Tomasz W. Glinka, Mojgan Sabet, Debora Rubio-Aparicio, Serge H. Boyer, Orville A. Pemberton, Ruslan Tsivkovski, Scott J. Hecker, Michael N. Dudley, David C. Griffith, Jonathan Parkinson, Kirk Nelson, Yu Chen, Ziad Tarazi

Publikováno v: Journal of Medicinal Chemistry. 63:7491-7507

Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the class D (OXA) e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0120b5dd24d3ace9b34c3d9db7858b70
https://doi.org/10.1021/acs.jmedchem.9b01976

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The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant

Autor: Olga Lomovskaya, Debora Rubio-Aparicio, Ruslan Tsivkovski, Jeff Loutit, Michael Dudley

Publikováno v: Antimicrobial agents and chemotherapy. 66(2)

QPX7728 is a cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. QPX7728 can be delivered systemically by the intravenous (i.v.) or oral route of administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dba58e6801ccf3df59389b214df8ea
https://pubmed.ncbi.nlm.nih.gov/34902261

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In Vitro Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa

Autor: Debora Rubio-Aparicio, Olga Lomovskaya, Mariana Castanheira, Jeffery S. Loutit, Dongxu Sun, Kirk Nelson, Jill M. Lindley, Ruslan Tsivkovski, Michael N. Dudley

Publikováno v: Antimicrobial Agents and Chemotherapy

QPX7728 is an ultrabroad-spectrum beta-lactamase inhibitor with potent inhibition of key serine and metallo beta-lactamases. QPX7728 enhances the potency of multiple beta-lactams in beta-lactamase-producing Enterobacterales and Acinetobacter spp. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0290222a344dd1c50ba5b6008fc88bb9
http://europepmc.org/articles/PMC8315991

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In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii

Autor: Olga Lomovskaya, Maxim Totrov, Dongxu Sun, Kirk Nelson, Michael N. Dudley, Debora Rubio-Aparicio, Ruslan Tsivkovski

Publikováno v: Antimicrob Agents Chemother

QPX7728 is a recently discovered ultra-broad-spectrum beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in beta-lactamase-produci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e128d6e5b6e17cfebf96e152dbf117
https://doi.org/10.1128/aac.01406-20

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In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms

Autor: Olga Lomovskaya, Kirk Nelson, Michael N. Dudley, Dongxu Sun, Debora Rubio-Aparicio

Publikováno v: Antimicrob Agents Chemother

QPX7728 is an investigational ultrabroad-spectrum-beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in isogenic strains of Gram-n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdd6840e0bc95da7f0890f46e1e7580
https://doi.org/10.1128/aac.00757-20

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Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

Autor: Dongxu Sun, Olga Lomovskaya, Michael N. Dudley, Kirk Nelson, Ruslan Tsivkovski, Debora Rubio-Aparicio

Publikováno v: Antimicrobial Agents and Chemotherapy

QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo-beta-lactamases at a nanomolar concentration range in biochemical assays with purified enzymes. The broad-spectrum inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513cea585ddb065c16f09d1c996aa931
http://europepmc.org/articles/PMC7269478

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Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

Autor: Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, Olga Lomovskaya, Kirk Nelson, Michael N. Dudley, Ruslan Tsivkovski

Publikováno v: Antimicrobial Agents and Chemotherapy

QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical assays. Microbiological studies using characterized strains were used to provide a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecaee1216998118a930341e909e56ce
http://europepmc.org/articles/PMC7269471

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Activity of Simulated Human Dosage Regimens of Meropenem and Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in an In Vitro Hollow-Fiber Model

Autor: Ziad Tarazi, Mojgan Sabet, Debora Rubio-Aparicio, David C. Griffith, Michael N. Dudley, Olga Lomovskaya, Thomas G. Nolan, Jonathan Parkinson

The objective of these studies was to evaluate the exposures of meropenem and vaborbactam that would produce antibacterial activity and prevent resistance development in carbapenem-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing Enterob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1ec8fd56fa22df8a1008c2ca623d61
https://europepmc.org/articles/PMC5786802/

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Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae

Autor: Michael N. Dudley, Mojgan Sabet, Ziad Tarazi, Olga Lomovskaya, Thomas G. Nolan, David C. Griffith, Jonathan Parkinson, Debora Rubio-Aparicio

Publikováno v: Antimicrobial Agents and Chemotherapy. 62

Meropenem-vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae . The objective of these studies was to evaluate the efficacy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f376ddc123a846fc3ae30a13f53383f
https://doi.org/10.1128/aac.01446-17

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