Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Debora G. Rodrigues"'
Autor:
Raul C. Maranhão, Debora G. Rodrigues, A.F. Padoveze, Elaine R. Tavares, Maria Denise Fajardo Pereira, Claudete J. Valduga
Publikováno v:
Atherosclerosis. 197:959-966
A cholesterol-rich nanoemulsion (LDE) that resembles LDL binds to the LDL receptors and after injection into the blood stream may concentrate in cells with LDL receptor overexpression, as occurs in neoplasias and other proliferative processes. Thus,
Autor:
Durvanei Augusto Maria, Ricardo David Couto, Olga M. Ibañez, Claudete J. Valduga, Debora G. Rodrigues, Raul C. Maranhão, Denise C. Fernandes
Publikováno v:
Cancer Chemotherapy and Pharmacology. 55:565-576
A cholesterol-rich microemulsion or nanoparticle termed LDE concentrates in cancer tissues after injection into the bloodstream. Here the cytotoxicity, pharmacokinetics, toxicity to animals and therapeutic action of a paclitaxel lipophilic derivative
Autor:
Debora G. Rodrigues, C.S. Chiattone, Raul C. Maranhão, Vania Tietsche de Moraes Hungria, Sérgio Paulo Bydlowski, Maria C. Latrilha
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:51-60
Previously we have shown that cholesterol-rich microemulsions that bind to LDL receptors have the ability to concentrate in acute myeloid leukemia cells and in ovarian and breast carcinomas. Thus, LDE may be used as a vehicle for drugs directed again
Autor:
Debora G. Rodrigues, Raul C. Maranhão, Renato Barboza, Cristiane Cabogrosso Covolan, Silvana Torossian Coradi
Publikováno v:
Journal of Pharmacy and Pharmacology. 54:765-772
A cholesterol-rich emulsion (LDE) is taken up by malignant cells which over-express low-density lipoprotein (LDL) receptors and thus may be used as a carrier for drugs directed against neoplastic cells. In this study, we associated the antineoplastic
Autor:
Debora G, Rodrigues
Publikováno v:
IDrugs : the investigational drugs journal. 12(8)
With the need for innovation in drug discovery and development and changes to patent laws that are enabling greater IP protection, many pharmaceutical companies are pursuing international cooperation agreements with foreign companies as part of a glo
Autor:
Silvia Regina Graziani, Debora G. Rodrigues, Claudete J. Valduga, Roberto Hegg, Raul C. Maranhão, L. A. Pires
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced toxicity and increased antitumor activity compared with paclitaxel-Cremophor EL. Here, a clinical study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c04e92d7203913bbc061d4ea791c0b
Autor:
Jesus Paula Carvalho, Raul C. Maranhão, Silvia Regina Graziani, Maria Luiza Nogueira Dias, Debora G. Rodrigues
Publikováno v:
Cancer chemotherapy and pharmacology. 59(1)
Objective: A cholesterol-rich nanoemulsion termed LDE concentrates in cancer tissues after injection into the bloodstream. The association of a derivatized paclitaxel to LDE showed lower toxicity and increased antitumoral activity as tested in a B16
Publikováno v:
Leukemia research. 29(8)
Hypocholesterolemia is a common finding in patients with acute leukemia (AL). The aim of this study is to investigate if blast myeloid and lynfoid cells take up more high density lipoprotein (HDL) cholesteryl esters than normal cells of the same orig
Autor:
Claudete J. Valduga, Ana C. Lo Prete, Debora G. Rodrigues, Raul C. Maranhão, C.H. Azevedo, Denise C. Fernandes
Publikováno v:
The Journal of pharmacy and pharmacology. 55(12)
A cholesterol-rich microemulsion (LDE) that binds to low-density lipoprotein (LDL) receptors is selectively taken up by malignant cells that overexpress those receptors and may be used as vehicle for antineoplastic agents. This study aimed to develop
Autor:
Debora G. Rodrigues, Raul C. Maranhão, D. F. Deus, Silvia Regina Graziani, Roberto Hegg, L. A. Pires
Publikováno v:
Journal of Clinical Oncology. 24:12038-12038
12038 Background: Previously we described the association of PCT to a cholesterol-rich microemulsion (LDE) that binds to low-density lipoprotein (LDL) receptors and concentrates in neoplastic tissues. The association is stable, preserves the anti-pro