Výsledky vyhledávání - "Debora G, Rodrigues"

Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit

Autor: Raul C. Maranhão, Debora G. Rodrigues, A.F. Padoveze, Elaine R. Tavares, Maria Denise Fajardo Pereira, Claudete J. Valduga

Publikováno v: Atherosclerosis. 197:959-966

A cholesterol-rich nanoemulsion (LDE) that resembles LDL binds to the LDL receptors and after injection into the blood stream may concentrate in cells with LDL receptor overexpression, as occurs in neoplasias and other proliferative processes. Thus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9053cf0f59c278067b0ba17c2a5379b8
https://doi.org/10.1016/j.atherosclerosis.2007.12.051

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Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies

Autor: Durvanei Augusto Maria, Ricardo David Couto, Olga M. Ibañez, Claudete J. Valduga, Debora G. Rodrigues, Raul C. Maranhão, Denise C. Fernandes

Publikováno v: Cancer Chemotherapy and Pharmacology. 55:565-576

A cholesterol-rich microemulsion or nanoparticle termed LDE concentrates in cancer tissues after injection into the bloodstream. Here the cytotoxicity, pharmacokinetics, toxicity to animals and therapeutic action of a paclitaxel lipophilic derivative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5e08154ba61f059568f3fa36295264
https://doi.org/10.1007/s00280-004-0930-y

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Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease

Autor: Debora G. Rodrigues, C.S. Chiattone, Raul C. Maranhão, Vania Tietsche de Moraes Hungria, Sérgio Paulo Bydlowski, Maria C. Latrilha

Publikováno v: Cancer Chemotherapy and Pharmacology. 53:51-60

Previously we have shown that cholesterol-rich microemulsions that bind to LDL receptors have the ability to concentrate in acute myeloid leukemia cells and in ovarian and breast carcinomas. Thus, LDE may be used as a vehicle for drugs directed again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3339c3e7502eae351eb94f3cfc2e48f
https://doi.org/10.1007/s00280-003-0692-y

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Use of a cholesterol-rich emulsion that binds to low-density lipoprotein receptors as a vehicle for paclitaxel

Autor: Debora G. Rodrigues, Raul C. Maranhão, Renato Barboza, Cristiane Cabogrosso Covolan, Silvana Torossian Coradi

Publikováno v: Journal of Pharmacy and Pharmacology. 54:765-772

A cholesterol-rich emulsion (LDE) is taken up by malignant cells which over-express low-density lipoprotein (LDL) receptors and thus may be used as a carrier for drugs directed against neoplastic cells. In this study, we associated the antineoplastic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabfd3758bc7ab458477ef6a22c0151d
https://doi.org/10.1211/0022357021779104

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Brazil: An emerging partner in drug RD

Autor: Debora G, Rodrigues

Publikováno v: IDrugs : the investigational drugs journal. 12(8)

With the need for innovation in drug discovery and development and changes to patent laws that are enabling greater IP protection, many pharmaceutical companies are pursuing international cooperation agreements with foreign companies as part of a glo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef50d44ea133b1ddd86a3ee141998a84
https://pubmed.ncbi.nlm.nih.gov/19629884

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Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study

Autor: Silvia Regina Graziani, Debora G. Rodrigues, Claudete J. Valduga, Roberto Hegg, Raul C. Maranhão, L. A. Pires

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced toxicity and increased antitumor activity compared with paclitaxel-Cremophor EL. Here, a clinical study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c04e92d7203913bbc061d4ea791c0b

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Pharmacokinetics and tumor uptake of a derivatized form of paclitaxel associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers

Autor: Jesus Paula Carvalho, Raul C. Maranhão, Silvia Regina Graziani, Maria Luiza Nogueira Dias, Debora G. Rodrigues

Publikováno v: Cancer chemotherapy and pharmacology. 59(1)

Objective: A cholesterol-rich nanoemulsion termed LDE concentrates in cancer tissues after injection into the bloodstream. The association of a derivatized paclitaxel to LDE showed lower toxicity and increased antitumoral activity as tested in a B16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c146450829340848924c976931f1b8
https://pubmed.ncbi.nlm.nih.gov/16699792

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Uptake of high density lipoprotein (HDL) cholesteryl esters by human acute leukemia cells

Autor: Debora G. Rodrigues, Raul C. Maranhão, R. Gonçalves

Publikováno v: Leukemia research. 29(8)

Hypocholesterolemia is a common finding in patients with acute leukemia (AL). The aim of this study is to investigate if blast myeloid and lynfoid cells take up more high density lipoprotein (HDL) cholesteryl esters than normal cells of the same orig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3709f27b843b9767c0cd62f8d2cf57
https://pubmed.ncbi.nlm.nih.gov/15978947

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Use of a cholesterol-rich microemulsion that binds to low-density lipoprotein receptors as vehicle for etoposide

Autor: Claudete J. Valduga, Ana C. Lo Prete, Debora G. Rodrigues, Raul C. Maranhão, C.H. Azevedo, Denise C. Fernandes

Publikováno v: The Journal of pharmacy and pharmacology. 55(12)

A cholesterol-rich microemulsion (LDE) that binds to low-density lipoprotein (LDL) receptors is selectively taken up by malignant cells that overexpress those receptors and may be used as vehicle for antineoplastic agents. This study aimed to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907aad46c4beb51ce90879c1be82013e
https://pubmed.ncbi.nlm.nih.gov/14738586

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Plasma kinetics, uptake by neoplastic breast tissue and preliminary toxicity data of a cholesterol-rich microemulsion (LDE) associated to a paclitaxel (PCT) derivative

Autor: Debora G. Rodrigues, Raul C. Maranhão, D. F. Deus, Silvia Regina Graziani, Roberto Hegg, L. A. Pires

Publikováno v: Journal of Clinical Oncology. 24:12038-12038

12038 Background: Previously we described the association of PCT to a cholesterol-rich microemulsion (LDE) that binds to low-density lipoprotein (LDL) receptors and concentrates in neoplastic tissues. The association is stable, preserves the anti-pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a2d48996cce82c391971eb07e9c05a3
https://doi.org/10.1200/jco.2006.24.18_suppl.12038

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