Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Debora B Petropolis"'
Autor:
Debora B Petropolis, Daniela M Faust, Matthieu Tolle, Lise Rivière, Tanguy Valentin, Christine Neuveut, Nora Hernandez-Cuevas, Alexandre Dufour, Jean-Christophe Olivo-Marin, Nancy Guillen
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148667 (2016)
Human liver infection is a major cause of death worldwide, but fundamental studies on infectious diseases affecting humans have been hampered by the lack of robust experimental models that accurately reproduce pathogen-host interactions in an environ
Externí odkaz:
https://doaj.org/article/d7e5a1b5f6274f158834a7bef6b101e3
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004381 (2014)
Investigations of human parasitic diseases depend on the availability of appropriate in vivo animal models and ex vivo experimental systems, and are particularly difficult for pathogens whose exclusive natural hosts are humans, such as Entamoeba hist
Externí odkaz:
https://doaj.org/article/d55132e55b314e4db4687796e7765e87
Autor:
Anne Freimoser-Grundschober, Ekaterina Breous-Nystrom, Heather Shannon Grant, Chaitra Belgur, Carina Hage, Anna Maria Giusti, Régine Gérard, Patrick Ray Ng, Martina Geiger, Lauriane Cabon, Adrian Roth, Katia Karalis, Nikolce Gjorevski, Tanja Fauti, Dimitris V. Manatakis, Johannes Sam, Christian Klein, William Tien-Street, Tina Weinzierl, Virginie Micallef, Thomas Singer, Anneliese Schneider, Debora B. Petropolis, Annie Moisan, Peter Bruenker, Jan Eckmann, Geraldine A. Hamilton, S. Jordan Kerns, Cristina Bertinetti-Lapatki, Riccardo Barrile, Michael Bscheider, Marina Bacac, Marianne Kanellias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3636b0fb4a5bf02fa3e3ab9b2eb29a8
https://doi.org/10.7554/elife.67106.sa2
https://doi.org/10.7554/elife.67106.sa2
Autor:
Dominic P. Williams, Pedro Caetano-Pinto, Janey Ronxhi, Beate Ehrhardt, Geraldine A. Hamilton, Lorna Ewart, Alison J. Foster, Samantha Peel, Konstantia Kodella, Matthew Boeckeler, Kyung-Jin Jang, Debora B. Petropolis, Adam Corrigan, Jonathan E. Rubins, Gauri Kulkarni
Publikováno v:
Peel, S, Corrigan, A M, Ehrhardt, B, Jang, K-J, Caetano-Pinto, P, Boeckeler, M, Rubins, J E, Kodella, K, Petropolis, D B, Ronxhi, J, Kulkarni, G, Foster, A J, Williams, D, Hamilton, G A & Ewart, L 2019, ' Introducing an automated high content confocal imaging approach for Organs-on-Chips ', Lab on a Chip, vol. 19, no. 3, pp. 410-421 . https://doi.org/10.1039/c8lc00829a
Organ-Chips are micro-engineered systems that aim to recapitulate the organ microenvironment. Implementation of Organ-Chips within the pharmaceutical industry aims to improve the probability of success of drugs reaching late stage clinical trial by g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927b6de8e264eb4c997149dc0b008ffd
https://doi.org/10.1039/c8lc00829a
https://doi.org/10.1039/c8lc00829a
Autor:
Katia Karalis, Anneliese Schneider, Riccardo Barrile, Annie Moisan, Peter Bruenker, William Tien-Street, Michael Bscheider, Patrick Ray Ng, Régine Gérard, Tanja Fauti, Anna Maria Giusti, Debora B. Petropolis, Ekaterina Breous-Nystrom, Marina Bacac, Johannes Sam, Thomas Singer, Adrian Roth, Nikolce Gjorevski, Tina Weinzierl, Virginie Micallef, Lauriane Cabon, Dimitris V. Manatakis, Carina Hage, Cristina Bertinetti-Lapatki, Jan Eckmann, Geraldine A. Hamilton, Christian Klein, S. Jordan Kerns, Chaitra Belgur, Marianne Kanellias, Anne Freimoser-Grundschober, Heather Shannon Grant, Martina Geiger
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two Organs-on-Chips to evaluate the safety profile of T-cell bispecif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0bc505b8f7bce39068eca295b02de7
https://pubmed.ncbi.nlm.nih.gov/34558412
https://pubmed.ncbi.nlm.nih.gov/34558412
Autor:
K. Karalis, Janey Ronxhi, Janna Nawroth, Dimitris V. Manatakis, Ekihiro Seki, Anke Witt, Gauri Kulkarni, Gabriel Burchett, Abhishek Shukla, Shelly C. Lu, Geraldine A. Hamilton, Katharina Schlünder, Tengku Ibrahim Maulana, Konstantia Kodella, Debora B. Petropolis
Publikováno v:
Cell reports
Cell reports, vol 36, iss 3
Cell reports, vol 36, iss 3
SUMMARY Alcohol-associated liver disease (ALD) is a global health issue and leads to progressive liver injury, comorbidities, and increased mortality. Human-relevant preclinical models of ALD are urgently needed. Here, we leverage a triculture human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d069f4474cbb2560faeee40c03ecaf
https://pubmed.ncbi.nlm.nih.gov/34289365
https://pubmed.ncbi.nlm.nih.gov/34289365
Autor:
Gabriel Burchett, Anke Witt, Shelly C. Lu, Tengku Ibrahim Maulana, Debora B. Petropolis, Schlünder K, Geraldine A. Hamilton, Janna Nawroth, K. Karalis, Abhishek Shukla, Ekihiro Seki, Dimitris V. Manatakis
Publikováno v:
SSRN Electronic Journal.
Fatty liver disease (FLD), is a major public health burden that affects up to 30% of people in Western countries and leads to progressive liver injury, comorbidities, and increased mortality. Key risk factors for developing FLD are obesity and alcoho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f657b9d80c928a460397ede713f6ed9
https://doi.org/10.2139/ssrn.3697330
https://doi.org/10.2139/ssrn.3697330
Autor:
Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic
Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992
Autor:
Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins
Publikováno v:
Science translational medicine. 11(517)
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12fac7c745aecb2cdd286e4f142c77
https://pubmed.ncbi.nlm.nih.gov/31776474
https://pubmed.ncbi.nlm.nih.gov/31776474
Autor:
Miguel Vargas, Debora B. Petropolis, Nancy Guillén, Gagan Deep Jhingan, Nora Adriana Hernández-Cuevas
Publikováno v:
Cellular Microbiology. 21
Actin is one of the most conserved, abundant, and ubiquitous proteins in all eukaryotes characterised to date. Posttranslation modifications of actin modify the organisation of the actin-rich cytoskeleton. In particular, chemical modifications of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d548d727a72b3c7fdbd5b714769a7bcc
https://doi.org/10.1111/cmi.12983
https://doi.org/10.1111/cmi.12983