Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Debora A. Casolari"'
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Bernard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mitochondrial metabolism has been associated with tumourigenesis in acute myeloid leukaemia (AML) and currently considered as a potential therapeutic target. Here, the authors show, in patients with AML, that germline mutations in mitochondrial compl
Externí odkaz:
https://doaj.org/article/80997f20894a4c6ab09d4081863d91de
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Benard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/358e6495258e4f5ea0b4793e347e5337
Autor:
Saumya E. Samaraweera, Tatjana Geukens, Debora A. Casolari, Tran Nguyen, Caitlyn Sun, Sheree Bailey, Sarah Moore, Jinghua Feng, Andreas W. Schreiber, Wendy T. Parker, Anna L. Brown, Carolyn Butcher, Peter G. Bardy, Michael Osborn, Hamish S. Scott, Dipti Talaulikar, Carolyn S. Grove, Christopher N. Hahn, Richard J. D'Andrea, David M. Ross
Publikováno v:
Pathology. 55:77-85
Refereed/Peer-reviewed The identification of a somatic mutation associated with myeloid malignancy is of diagnostic importance in myeloproliferative neoplasms (MPNs). Individuals with no mutation detected in common screening tests for variants in JAK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179f391d9840838f51051dcf2a1689a7
https://doi.org/10.1016/j.pathol.2022.05.015
https://doi.org/10.1016/j.pathol.2022.05.015
Autor:
Amke Trentmann, Debora A. Casolari, Maria V. Yusenko, Henning D. Mootz, Jan-Henrik Mikesch, Karl-Heinz Klempnauer, Mairin Lenz, Maria Francisca Arteaga, Richard J D'Andrea, Wolfgang Dörner, Stefan Klempnauer, Thomas J. Schmidt, Luca Abdel Ghani, Melanie Horn, Carsten Müller-Tidow, Thomas J. Gonda
Publikováno v:
Oncogene
Transcription factor MYB has recently emerged as a promising drug target for the treatment of acute myeloid leukemia (AML). Here, we have characterized a group of natural sesquiterpene lactones (STLs), previously shown to suppress MYB activity, for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99594c1cb67990ef093aab785965f213
http://europepmc.org/articles/PMC8298201
http://europepmc.org/articles/PMC8298201
Autor:
John Toubia, Hannah McCalmont, Debora A. Casolari, Chelsea Mayoh, Saumya E. Samaraweera, Richard J D'Andrea, Sarah C Bray, Ka Leung Li, Ian D. Lewis, Rab K. Prinjha, Nicholas Smithers, Luke Jones, Shudong Wang, Richard B. Lock
Publikováno v:
Blood Advances. 4:296-300
Chromosomal rearrangements of the lysine methyltransferase 2A (KMT2A or MLL) gene are observed in ;10% of all acute leukemias, with particularly high frequency (;80%) in infant acute lymphoblastic leukemia (ALL),1 where, despite aggressive chemothera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac76a42f5d50145a4ad43bba4449e8e2
https://doi.org/10.1182/bloodadvances.2019000586
https://doi.org/10.1182/bloodadvances.2019000586
Autor:
David M. Ross, Amanda Smith, Andreas W. Schreiber, Saumya E. Samaraweera, Hamish S. Scott, Amilia Wee, Jonathan Ellis, Christopher N. Hahn, Mark Pinese, Debora A. Casolari, Andrew J. Deans, Paul Leo, Paul Po-Shen Wang, Kyaw Ze Ya Maung, Thomas J. Gonda, Richard J D'Andrea, Anna L. Brown, Kelly Perkins, Mark J. Cowley, Ka Leung Li, Devendra K Hiwase, Andrew S. Moore, Jinghua Feng
Publikováno v:
Blood. 138(22)
As germline variants can influence cancer patient treatment decisions, outcomes and counselling, and the level of genetic predisposition for sporadic childhood acute myeloid leukemia (AML) is not clearly established, we undertook a comprehensive anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d73a3b419068bf70e5f3dbded02a3c4
https://pubmed.ncbi.nlm.nih.gov/34521114
https://pubmed.ncbi.nlm.nih.gov/34521114
Autor:
Richard J D'Andrea, Andrew J. Deans, Anna L. Brown, James X Gray, Paula Marlton, Thomas J. Gonda, Sarah C Bray, Luen Bik To, Ian D. Lewis, Matthew A. Brown, Tran Nguyen, Debora A. Casolari, Emma L. Duncan, Paul Leo, Vinay Tergaonkar, Gökhan Cildir, Devinder Gill, Stephen Pederson, Saumya E. Samaraweera, Adam D. Ewing, Russell Saal, Mhairi Marshall, Mahmoud A. Bassal, Kyaw Ze Ya Maung, Deepak Singhal
Publikováno v:
Blood Cancer Journal, Vol 8, Iss 6, Pp 1-5 (2018)
Blood Cancer Journal
Blood Cancer Journal
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy caused by somatically acquired changes affecting a well-defined set of genes1. While rare high-risk variants affecting specific transcription factors account for a proportion of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2185a7cffd743552938423e09196d9b9
http://link.springer.com/article/10.1038/s41408-018-0090-7
http://link.springer.com/article/10.1038/s41408-018-0090-7
Autor:
Sarah Moore, Tran Nguyen, Richard J D'Andrea, David M. Ross, Merel J. M. Van Velzen, Christopher N. Hahn, Debora A. Casolari, Ing Soo Tiong, Hamish S. Scott, Daniela Zantomio
Publikováno v:
British Journal of Haematology. 178:333-336
Here we report a case of WHO-defined PV with no JAK2mutation detected on routine testing using a single nucleotideprimer extension assay for JAK2 V617F and directsequencing of exon 12. Targeted next generation sequencing(NGS) of the entire coding reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcd5374e4d799413489fdcf610bf132
https://doi.org/10.1111/bjh.14126
https://doi.org/10.1111/bjh.14126
Autor:
Amilia Wee, Sarah C Bray, Petra J. Neufing, Christopher N. Hahn, Kyaw Ze Ya Maung, Chung H. Kok, C. M. Butcher, Peter Bardy, Susan Branford, Richard J D'Andrea, David M. Ross, Diana Iarossi, Ljiljana Vidovic, Hamish S. Scott, Ian D. Lewis, Tran Nguyen, Debora A. Casolari, Wendy T Parker, Steven W. Lane, Jinghua Feng
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
We describe a novel ERBB1/EGFR somatic mutation (p. C329R; c.985 T > C) identified in a patient with JAK2V617F Polycythaemia Vera (PV). This substitution affects a conserved cysteine residue in EGFR domain 2 and leads to the formation of a ligand-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a4b42527772ccf6d382e95b27d55c2
https://doi.org/10.1038/s41598-017-02655-7
https://doi.org/10.1038/s41598-017-02655-7
Autor:
Estrella Gonzales-Aloy, Hangyu Yi, Debora A. Casolari, Michelle Haber, Murray D. Norris, Jingyi Wang, Richard J D'Andrea, Florida Voli, Tao Liu, Ivor Lewis, Tsz Kan Fung, Jacqueline Lynch, Chintae So, Amie Brown, Bo Liu
Publikováno v:
Leukemia. 30(8)
Self-renewal and differentiation block are two key features of leukemic stem cells (LSCs) in mixed-lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML), which can originate from either hematopoietic stem cells (HSCs) or granulocyte macropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fa98f211e42043f0b1d61375486c25
https://pubmed.ncbi.nlm.nih.gov/26859074
https://pubmed.ncbi.nlm.nih.gov/26859074