Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Debopam Chakrabarti"'
Autor:
Tiantian Jiang, Karla P. Godinez-Macias, Jennifer E. Collins, Jin Woo Lee, Karen L. Wendt, Krypton Carolino, Debopam Chakrabarti, Robert H. Cichewicz, Elizabeth A. Winzeler
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTIn an effort to identify novel compounds with potent inhibition against Toxoplasma gondii, a phenotypic screen was performed utilizing a library of 683 pure compounds derived primarily from terrestrial and marine fungi. An initial screen with
Externí odkaz:
https://doaj.org/article/976144716c214d25b83176354f70ecae
Autor:
Ramanjaneyulu Rayala, Prakash Chaudhari, Ashley Bunnell, Bracken Roberts, Debopam Chakrabarti, Adel Nefzi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17414 (2023)
Thiazole and piperazine are two important heterocyclic rings that play a prominent role in nature and have a broad range of applications in agricultural and medicinal chemistry. Herein, we report the parallel synthesis of a library of diverse piperaz
Externí odkaz:
https://doaj.org/article/6c08936a13264ced93cb4a3818be4671
Autor:
Claribel Murillo-Solano, Beau R. Brummel, David L. Perry, James R. Rocca, Debopam Chakrabarti
Publikováno v:
ACS Omega, Vol 6, Iss 31, Pp 20455-20470 (2021)
Externí odkaz:
https://doaj.org/article/f54a53c6a16648b8ba7b5b0303d98199
Autor:
Arash Keshavarzi Arshadi, Milad Salem, Jennifer Collins, Jiann Shiun Yuan, Debopam Chakrabarti
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Antimalarial drugs are becoming less effective due to the emergence of drug resistance. Resistance has been reported for all available malaria drugs, including artemisinin, thus creating a perpetual need for alternative drug candidates. The tradition
Externí odkaz:
https://doaj.org/article/178e3e8e90164e7ba5a9322b5c16c916
Autor:
Bracken F. Roberts, Yongsheng Zheng, Jacob Cleaveleand, Sukjun Lee, Eunyoung Lee, Lawrence Ayong, Yu Yuan, Debopam Chakrabarti
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 1, Pp 120-129 (2017)
Drugs against malaria are losing their effectiveness because of emerging drug resistance. This underscores the need for novel therapeutic options for malaria with mechanism of actions distinct from current antimalarials. To identify novel pharmacopho
Externí odkaz:
https://doaj.org/article/ad7ae177b07a4062931744b7418a6881
Autor:
Amy E. Wright, Jennifer E. Collins, Bracken Roberts, Jill C. Roberts, Priscilla L. Winder, John K. Reed, Maria Cristina Diaz, Shirley A. Pomponi, Debopam Chakrabarti
Publikováno v:
Marine Drugs, Vol 19, Iss 4, p 179 (2021)
Novel drug leads for malaria therapy are urgently needed because of the widespread emergence of resistance to all available drugs. Screening of the Harbor Branch enriched fraction library against the Plasmodium falciparum chloroquine-resistant strain
Externí odkaz:
https://doaj.org/article/57aa25217af14816b654484b19cf1cbc
Autor:
Bracken F. Roberts, Iredia D. Iyamu, Sukjun Lee, Eunyoung Lee, Lawrence Ayong, Dennis E. Kyle, Yu Yuan, Roman Manetsch, Debopam Chakrabarti
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 85-92 (2016)
We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compoun
Externí odkaz:
https://doaj.org/article/b3223fd5ee9f43ceb352591e50d42e0a
Autor:
Fernanda C. Koyama, Mauro F. Azevedo, Alexandre Budu, Debopam Chakrabarti, Célia R. S. Garcia
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22320-22330 (2014)
There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes,
Externí odkaz:
https://doaj.org/article/00debcdc03944fd3985afac1793ea463
Autor:
Peter J. McCarthy, Bracken F. Roberts, Abigail Carbonell, Jill Roberts, Amy E. Wright, Debopam Chakrabarti
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 4, Iss 3, p 103 (2019)
It is important to discover novel antimalarial pharmacophores because of the widespread emergence of Plasmodium falciparum isolates resistant to the available drugs. Secondary metabolites derived from microbes associated with marine invertebrates are
Externí odkaz:
https://doaj.org/article/926c2235627f40f0a31bef33e8e414d4
Autor:
David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi
Publikováno v:
Molecules, Vol 24, Iss 6, p 1100 (2019)
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries
Externí odkaz:
https://doaj.org/article/2d655bfb332b4b94a977f44bf46cb60a