Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Debnath Bhuniya"'
Autor:
Summon Koul, Suresh Kurhade, Sandeep Bhosale, Keshav Naik, Videsh Salunkhe, Sudhir Ravula, Prasad Punde, Ravikumar Velayutham, Atul Tiwari, Daniela Ahl, Srividya Malkapuram, Vamsi Mudagala, Amol Raje, Dhananjay Umrani, Suhas Tambe, Poonam Patil, Umesh Singh, Debnath Bhuniya, Narayanan Hariharan, Kasim Mookhtiar
Publikováno v:
Bioorganicmedicinal chemistry letters. 62
A series of novel spirocyclic DGAT1 inhibitors containing the oxadiazole motif were designed and synthesized for biological evaluation. Several compounds exhibited potent diacylglycerol acyltransferase 1 (DGAT1) inhibitory activity. Optimization of t
Autor:
Madhu bala, Partha P. Mukhopadhyay, Kasim A. Mookhtiar, Bheemashankar Kulkarni, Nadim S. Shaikh, Amol A. Raje, Dhananjay N. Umrani, Debnath Bhuniya, Prasad Sherkar, Yogesh Munot, Sachin Joshi, Satyanarayan Reddy, Vishwottam Kandikere, Mahendra Lohote, Jitesh P. Iyer, Vijay Jamdar, Rajkanth Petla, Ranganayaki Nagaraj, Ravindra Gavhane, Ashwinkumar V. Meru, Sreekanth R. Rouduri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2208-2217
Targeting nuclear receptor RORγ is recognized to be beneficial in multiple autoimmune disorders. We disclosed new indole analogues as potent RORγ inverse agonists. RO-2 as one of the potent and orally bioavailable compounds was evaluated in various
Autor:
Ashwinkumar V. Meru, Siddhartha De, Debnath Bhuniya, Nadim S. Shaikh, Kasim A. Mookhtiar, Kaushal Joshi, Rashmi Barbhaiya, Vamsi Madgula, Sandeep Bhosale, Amol A. Raje, Rajendra K. Kharul, Dhananjay Joshi, Amol Magdum, Fouzia Begum, Sonalee Athavankar, Hajare Atul Kashinath, Sandip Balwe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:238-243
Conceptual design and modification of urea moiety in chemotype PF-3845/04457845, the bench marking irreversible inhibitor of fatty acid amide hydrolase (FAAH), led to discovery of a novel nicotinamide-based lead 12a having reversible mechanism of act
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2285-2288
A new class of isoxazole-tethered diarylheptanoids having characteristic 1,3-syn-diol and 1,3-anti-diol chemophoric moieties, e.g. 4a–d and 5a–c respectively, have been designed and synthesized starting from d -glucose following a stereo-conserve
Autor:
Srikant Viswanadha, Gayatriswaroop Merikapudi, Sridhar Veeraraghavan, Debnath Bhuniya, Kondababu Rasamsetti, Satyanarayana Eleswarapu, Swaroop Vakkalanka
Publikováno v:
Cancer Research. 81:1233-1233
Background: Poly (ADP-ribose) polymerase (PARP) activity involves synthesis of Poly-ADP ribose (PAR) polymers that recruit host DNA repair proteins leading to correction of DNA damage and maintenance of cell viability. Upon combining with DNA damagin
Autor:
Kasim A. Mookhtiar, Anita Chugh, Rahul D. Kaduskar, Siddhartha De, Dhananjay N. Umrani, Debnath Bhuniya, Keshav Naik, Santosh Kurhade, Prasad Shitole, Balasaheb Kobal, Pratima Patil, Amol A. Raje, Sandhya Chaturvedi Joshi, Vamsi Madgula, Vaibhav Jain, Satyanarayana Reddy, Vyavahare Vinod, Suhas Tambe, Venkata P. Palle, Jayasagar Gundu, Ganesh Bhat, Bhavesh Dave, Anil M. Deshpande, Sachin Kandalkar, Sujay Basu
Publikováno v:
European Journal of Medicinal Chemistry. 133:268-286
Glucokinase activators (GKAs) are among the emerging drug candidates for the treatment of type 2 diabetes (T2D). Despite effective blood glucose lowering in clinical trials, many pan-GKAs "acting both in pancreas and liver" have been discontinued fro
Autor:
Salunkhe Videsh, Madhu bala, Avinash Dhanave, Tanaji Mengawade, Vamsi Madgula, Mahesh Thakkar, Keshav Naik, Bheemashankar Kulkarni, Rahul D. Kaduskar, Dhananjay N. Umrani, Santosh Kurhade, Sachin Joshi, Amit Bhalerao, Sreekanth R. Rouduri, Vishal V Pathade, Rajkanth Petla, Swagatam Ray, Narayanan Hariharan, Kasim A. Mookhtiar, Satheesh Veerappa Avaragolla, Debnath Bhuniya, Jagadeesh Mavinahalli, Ashwini Tambe, Vaibhav Jain, Siddhartha De, Amol A. Raje, Ahmed Nadeem
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1867-1873
In a pursuit to identify reversible and selective BTK inhibitors, two series based on 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[2,3-b]pyridine as the hinge binding core, have been identified. Structure activity relationship (SAR) exploration led to
Autor:
Debnath Bhuniya, Rao Mukkavilli, Rahul Shivahare, Anil M. Deshpande, Ravindra T. Dere, Hari N. Pati, Vadiraj S. Gopinath, Ashok Pradhan, Manjunath Moger, Denis Martin, Suman Gupta, Preeti Vishwakarma, Delphine Launay, Aditya Verma, Sunil K. Puri
Publikováno v:
European Journal of Medicinal Chemistry. 102:582-593
As part of Drugs for Neglected Diseases initiative's lead optimization program for the development of new chemical entities to treat visceral leishmaniasis (VL), a series of aminothiazoles were synthesized and screened for in vitro efficacy, solubili
Autor:
Summon Koul, Debnath Bhuniya, Satheesh Veerappa Avaragolla, Parimi Atchuta Ramaiah, Vandana Rajopadhyay, Santosh Kurhade
Publikováno v:
Tetrahedron Letters. 55:2415-2419
l -( N -Cbz)-7-azaisotryptophan, l -( N -Cbz)- 1a , a new isostere of tryptophan, was synthesized by reacting Li 2 -( N -Boc)-2-amino-3-picoline, Li 2 -( N -Boc)- 2a , with appropriately protected l -aspartic acid followed by simple functional group
Publikováno v:
Synthesis. 45:1689-1692
The synthesis of a recently identified and highly active sex pheromone of the longtailed mealybug, Pseudococcus longispinus is reported. A concise synthetic route, use of the under explored Meyer–Schuster rearrangement, Claisen rearrangement, and r