Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Debjani Pal"'
Autor:
Miguel Toro-González, Ngozi Akingbesote, Amber Bible, Debjani Pal, Brian Sanders, Alexander S. Ivanov, Santa Jansone-Popova, Ilja Popovs, Paul Benny, Rachel Perry, Sandra Davern
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Targeted alpha therapy (TAT) relies on chemical affinity or active targeting using radioimmunoconjugates as strategies to deliver α-emitting radionuclides to cancerous tissue. These strategies can be affected by transmetalation of the paren
Externí odkaz:
https://doaj.org/article/c718824527bd4c548764d816c9f11ed2
Autor:
Debjani Pal, Kuntal De, Carly M. Shanks, Kai Feng, Timothy B. Yates, Jennifer Morrell-Falvey, Russell B. Davidson, Jerry M. Parks, Wellington Muchero
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are essential for HGF/c-MET signaling and regulate their interaction, perinuclear localization, and cellular internalization. Thus, targeting PAN may represent a mechanism for the
Externí odkaz:
https://doaj.org/article/6723ce81c6c14178bfb99e772c5987d5
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106274- (2023)
Summary: The global pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has become a severe global health problem because of its rapid spread. Both Ace2 and NRP1 provide initial viral bind
Externí odkaz:
https://doaj.org/article/777642b625014d7d8f47827f30b955e7
Autor:
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Publikováno v:
eLife, Vol 10 (2021)
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the course of trea
Externí odkaz:
https://doaj.org/article/8f753d647a7d4f28ad16d9538172ef03
Autor:
Mahdi Zamanighomi, Sidharth S. Jain, Takahiro Ito, Debjani Pal, Timothy P. Daley, William R. Sellers
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Systems for CRISPR-based combinatorial perturbation of two or more genes are emerging as powerful tools for uncovering genetic interactions. However, systematic identification of these relationships is complicated by sample, reagent, and bio
Externí odkaz:
https://doaj.org/article/19f25f52f5d641b5b721773d4511b856
Autor:
Serif Senturk, Nitin H. Shirole, Dawid G. Nowak, Vincenzo Corbo, Debjani Pal, Alexander Vaughan, David A. Tuveson, Lloyd C. Trotman, Justin B. Kinney, Raffaella Sordella
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
CRISPR/Cas9-based genome editing enables specific deletion of target genes. Here, Senturket al. develop an inducible editing system by fusing a conditional destabilization domain to Cas9 and demonstrate temporal control of gene editing in response to
Externí odkaz:
https://doaj.org/article/12bf0bf4ae954de9832a7c856f71605e
Autor:
Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/f2b4618c51e34ff391898364f003aa4b
Autor:
Debjani Pal, Anja Pertot, Nitin H Shirole, Zhan Yao, Naishitha Anaparthy, Tyler Garvin, Hilary Cox, Kenneth Chang, Fred Rollins, Jude Kendall, Leyla Edwards, Vijay A Singh, Gary C Stone, Michael C Schatz, James Hicks, Gregory J Hannon, Raffaella Sordella
Publikováno v:
eLife, Vol 6 (2017)
Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanism
Externí odkaz:
https://doaj.org/article/b7f989bbb5ea4d239de1e7c89e4b0fc4
Autor:
Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella
Publikováno v:
eLife, Vol 5 (2016)
TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected frequencies and produce proteins that lack canonical p53 tumor su
Externí odkaz:
https://doaj.org/article/0ca2ccc471344a649b1d2de0b77d056c
Publikováno v:
International Journal of Medicine & Public Health. Jan-Mar2022, Vol. 12 Issue 1, p28-32. 5p.