Výsledky vyhledávání

Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1

Autor: Yujeong Lee, Yoshiyuki Onishi, Lisa McPherson, Anna M. Kietrys, Marian Hebenbrock, Yong Woong Jun, Ishani Das, Shanthi Adimoolam, Debin Ji, Michael G. Mohsen, James M. Ford, Eric T. Kool

Publikováno v: ACS Chemical Biology. 17:2074-2087

Impaired DNA repair activity has been shown to greatly increase rates of cancer clinically. It has been hypothesized that upregulating repair activity in susceptible individuals may be a useful strategy for inhibiting tumorigenesis. Here, we report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a752122c9007342d181d33a1590b96c
https://doi.org/10.1021/acschembio.2c00038

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The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors

Autor: Govindi J. Samaranayake, Antonio Barrientos, Priyamvada Rai, Mahsa Karbaschi, Christina J. Jayaraj, Dao M. Nguyen, Clara I. Troccoli, Eric T. Kool, Ling Zhang, Mai Huynh, Lisa A. McPherson, Yoshiyuki Onishi, Marcus S. Cooke, Debin Ji, David J. Robbins

Publikováno v: Molecular Cancer Therapeutics. 19:432-446

Investigations into the human 8-oxodGTPase, MutT Homolog 1 (MTH1), have risen sharply since the first-in-class MTH1 inhibitors were reported to be highly tumoricidal. However, MTH1 as a cancer therapeutic target is currently controversial because sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d203d7859af65d4e97e4e33a7ccf0dde
https://doi.org/10.1158/1535-7163.mct-19-0437

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Effect of phosphate additive on the morphology and anti-corrosion performance of plasma electrolytic oxidation coatings on magnesium―lithium alloy

Autor: Qing Kuang, Xuexia Wang, Xiaoyan Jing, Qinghui Ren, Zhijun Li, Debin Ji, Ruixia Yuan

Publikováno v: Corrosion Science. 157:295-304

The widespread use of magnesium―lithium (Mg―Li) alloys is frequently hampered by the grand challenge associated with their high propensity to corrosion. Herein, we describe a method to access anti-corrosion coatings on Mg―8.5Li alloy employing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5eb09e1e3bd7b94c626082c317c77cc4
https://doi.org/10.1016/j.corsci.2019.06.005

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Polymerase synthesis of four-base DNA from two stable dimeric nucleotides

Autor: Michael G. Mohsen, Eric T. Kool, Debin Ji

Publikováno v: Nucleic Acids Research

We document the preparation and properties of dimerized pentaphosphate-bridged deoxynucleotides (dicaptides) that contain reactive components of two different nucleotides simultaneously. Importantly, dicaptides are found to be considerably more stabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4e15f420516ed86fb4dad1c10be3a2
http://europepmc.org/articles/PMC6765132

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Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03901a

Autor: Michael G. Mohsen, Eric T. Kool, Debin Ji

Publikováno v: Chemical Science

ATP-releasing nucleotides are employed to detect single nucleotide polymorphisms in a novel method that is sensitive, rapid, and isothermal.
The identification of single nucleotide polymorphisms (SNP) is increasingly important for diagnosis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11b007966c0b8d2cd5c2cb2d8757c8e
http://europepmc.org/articles/PMC6429602

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Akademický článek

Facile enzymatic synthesis of base J-containing oligodeoxyribonucleotides and an analysis of the impact of base J on DNA replication in cells.

Autor: Debin Ji, Yinsheng Wang

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e103335 (2014)

We reported here the use of T4 bacteriophage β-glucosyltransferase (T4 β-GT) for the facile synthesis of base J-containing oligodeoxyribonucleotides (ODNs). We found that the enzyme could catalyze the glucosylation of 5-hydroxymethyl-2-deoxyuridine

Externí odkaz: https://doaj.org/article/0944296995114b1783bbcb3f5964a6c0

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