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BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner

Autor: Åke Sjöholm, Lars Forsberg, Ming Lu, Robert Bränström, Qimin Zhang, Deben Dey, Fan Zhang

Publikováno v: American Journal of Physiology-Cell Physiology. 296:C346-C354

BLX-1002 is a novel small thiazolidinedione with no apparent affinity to peroxisome proliferator-activated receptors (PPAR) that has been shown to reduce glycemia in type 2 diabetes without adipogenic effects. Its precise mechanisms of action, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8823c6ab753d4d83f4433209ba5599d6
https://doi.org/10.1152/ajpcell.00444.2008

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Pharmacokinetic studies with BLX‐1026, a novel Orexin‐2 receptor agonist with anti‐obesity property, in rats

Autor: Abjijeet Nag, Deben Dey, Partha Neogi, Aparna Mukherjee, Biswajit Nag, Ananda Sen

Publikováno v: The FASEB Journal. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77e6df9b436a0cf12cdd8fe4cfa3dcb9
https://doi.org/10.1096/fasebj.22.1_supplement.922.1

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BLX‐1060: A dose‐dependent efficacy study in collagen‐induced arthritis in mice

Autor: Deben Dey, Hyang Vargas, Bishwajit Nag, Ananda Sen, Abhijeet Nag, Partha Neogi

Publikováno v: The FASEB Journal. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aff0fde221842898fe3602cb07232ae2
https://doi.org/10.1096/fasebj.20.5.a1127-a

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Anti‐inflammatory property of BLX‐1060, an orally active TNF‐α inhibitor

Autor: Ananda Sen, Abhijeet Nag, Bishwajit Nag, Partha Neogi, Deben Dey

Publikováno v: The FASEB Journal. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf7ea04cc1152b3ccff5d55b22ec5ab5
https://doi.org/10.1096/fasebj.20.4.a266-b

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BLX‐1028, an orally active small molecules having anti‐adipogenic property, reduces weight gain, fat content and improves glucose tolerance in Diet Induced Obesity model in mice

Autor: Hyang Moon, Deben Dey, Bishwajit Nag, Shyamali Roy, Ananda Sen, Abhijeet Nag, Partha Neogi

Publikováno v: The FASEB Journal. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e841759edf0abccc58aeb3c214f3484
https://doi.org/10.1096/fasebj.20.4.a266-c

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Amino acid conjugated small molecule BLX-1002 lowers blood glucose in insulin resistant db/db and ob/ob mice and inhibits TNF-? , IL-6 cytokines

Autor: Mansi Chovatia, Deben Dey, Bindu Pandey, Ivan Peng, Bishwajit Nag, Abhijeet Nag, Partha Neogi

Publikováno v: American Journal of Hypertension. 17:S32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2951e5edc61c8cbf2458e1f8eda0006d
https://doi.org/10.1016/j.amjhyper.2004.03.071

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A new anti-diabetic compound, CLX-0921: Efficacy in rodent models of type II diabetes and syndrome X

Autor: Maya S. Gowri, Deben Dey, Gerald M. Reaven, Partha Neogi, Satya Medicherla, Biswajit Nag

Publikováno v: Diabetes Research and Clinical Practice. 50:344

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7409793d23870f6a92095a823f4e2651
https://doi.org/10.1016/s0168-8227(00)81176-6

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