Association between Clinical Frailty Scale score and hospital mortality in adult patients with COVID-19 (COMET): an international, multicentre, retrospective, observational cohort study

Autor: Agnoletto, LA, Aleman, J, Andreassi, S, Andrews, LM, Ashfield, L, Bell, H, Bengaard, AKB, Berlinghini, SB, Bini, KB, Bisoffi, ZB, Blum, KB, Boemaars, E, Boni, GB, Bosch, TM, Bosma, BE, Boutkourt, F, Bufarini, C, Bulsink, A, Cabuk, RC, Callens, GC, Candela, MC, Canonici, MC, Capone, EC, Carmo, IC, Caruso, FC, Chessa, PC, Cohet, GC, Cornelissen-Wesseling, I, Crommentuijn, KML, de Stoppelaar, FM, de Wit, HAJM, Deben, DS, Derijks, LJJ, Di Carlo, MDC, Diepstraten, J, Dilek, B, Duchek-Mann, DMK, Ebbens, MM, Ellerbroek, LJ, Ezinga, M, Falcao, MF, Falcao, FF, Fantini, LF, Farinha, HF, Filius, PMG, Fitzhugh, NJ, Fleming, G, Forsthuber, TF, Gambarelli, GG, Gambera, MG, García Yubero, CGY, Getrouw, Z, Ghazarian, CN, Goodfellow, N, Gorgas, MQG, Grinta, RG, Guda, K, Haider, DH, Hanley, J, Heitzeneder, KH, Hemminga, WL, Hendriksen, LC, Hilarius, DL, Hogenhuis, FEF, Hoogendoorn-de Graaf, IC, Houlind, MBH, Huebler, MAH, Hurkens, KPGM, Janssen, PKC, Jong, E, Kappers, MHW, Keijzers, KFM, Kemogni, MK, Kemper, EM, Kranenburg, RA, Krens, LL, Le Grand, JL G, Liang, J, Lim, S, Lindner, NL, Loche, EL, Lubich, AL, Maat, B, Maesano, CM, Maiworm, AM, Maragna, M, Marchesini, FM, Martignoni, IM, Martini, G M, Masini, CM, Mc Menamin, R, Mendes, DM, Miarons, M, Moorlag, R, Müller, MR, Nagele, FN, Nemec, KN, Oka, GO, Otten-Helmers, AG, Pagliarino, SP, Pappalardo, FP, Patel, M, Peverini, PM, Pieraccini, FP, Platania, EMP, Pons-Kerjean, NPK, Portillo Horcajada, LPH, Rametta, GR, Rijo, JR, Roelofsen, EE, Roobol-Meuwese, E, Rossi, LR, Russel, SAH, Safipour, Z, Salaffi, FS, Saleh, L, Schimizzi, AMS, Schols, JMGA, Schwap, MS, Scott, MG, Slijfer, EAM, Slob, EMA, Soares, JS, Solano, MS, Sombogaard, F, Stemer, GS, Tardella, MT, ter Horst, PGJ, Tessari, RT, Tournoy, J, van den Berg, RB, Van der Linden, L, van der Linden, PD, van Dijk, SC, Van Etten, RW, van Haelst, IMM, van Heuckelum, M, van Kan, HJM, van Nieuwkoop, C, van Onzenoort, HAW, van Wijngaarden, P, Verdonk, JDJ, Verri, Fv, Verstijnen, JAMC, Veyrier, MV, Viegas, EV, Visser, LE, Vos, A, Vromen, MAM, Wierenga, PC, Wong, DR, Zenico, CZ, Zuppini, TZ, Sablerolles, Roos S G, Lafeber, Melvin, van Kempen, Janneke A L, van de Loo, Bob P A, Boersma, Eric, Rietdijk, Wim J R, Polinder-Bos, Harmke A, Mooijaart, Simon P, van der Kuy, Hugo ^*, Versmissen, Jorie, Faes, Miriam C

Publikováno v: In The Lancet Healthy Longevity March 2021 2(3):e163-e170

Early therapeutic drug monitoring helps to identify inflammatory bowel disease patients with a high risk to fail thiopurine treatment.

Autor: Deben DS; Department of Clinical Pharmacy, Clinical Pharmacology and Toxicology, Zuyderland Medical Centre, Sittard-Geleen/Heerlen, Netherlands., Winkens B; Department of methodology and statistics, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, Netherlands., van Moorsel SAW; Department of Pharmacy, Jeroen Bosch Hospital, 's-Hertogenbosch, Netherlands.; Department of Clinical Pharmacy, Bernhoven Hospital, Uden, Netherlands., van Oijen BPC; Department of Clinical Pharmacy, Clinical Pharmacology and Toxicology, Zuyderland Medical Centre, Sittard-Geleen/Heerlen, Netherlands., Bus P; Department of Gastroenterology and Hepatology, Laurentius Hospital, Roermond, Netherlands., Pierik MJ; Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, Netherlands., Simsek M; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands., de Boer NKH; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, Netherlands., Leers MPG; Department of Clinical Chemistry and Hematology, Zuyderland Medical Centre, Sittard-Geleen/Heerlen, Netherlands.; Faculty of Science, Open Universiteit, Heerlen, Netherlands., Wong DR; Department of Clinical Pharmacy, Clinical Pharmacology and Toxicology, Zuyderland Medical Centre, Sittard-Geleen/Heerlen, Netherlands., van Bodegraven AA; Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, Netherlands.; Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre, Sittard-Geleen/Heerlen, Netherlands.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Dec; Vol. 90 (12), pp. 3296-3307. Date of Electronic Publication: 2024 Aug 25.

Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency.

Autor: Deben DS; Department of Clinical Pharmacy, Clinical Pharmacology and Toxicology, Zuyderland Medical Centre, 6162 BG Sittard, The Netherlands., Derijks LJJ; Department of Clinical Pharmacy and Pharmacology, Máxima Medical Centre, 5504 DB Veldhoven, The Netherlands., van den Bosch BJC; Department of Clinical Genetics, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands., Creemers RH; Department of Gastroenterology, Zuyderland Medical Centre, 6162 BG Sittard, The Netherlands.; Department of Gastro-Enterology, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands., van Nunen A; Department of Gastroenterology, Zuyderland Medical Centre, 6162 BG Sittard, The Netherlands., van Bodegraven AA; Department of Gastroenterology, Zuyderland Medical Centre, 6162 BG Sittard, The Netherlands.; Department of Gastro-Enterology, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands., Wong DR; Department of Clinical Pharmacy, Clinical Pharmacology and Toxicology, Zuyderland Medical Centre, 6162 BG Sittard, The Netherlands.

Publikováno v: Metabolites [Metabolites] 2023 Oct 06; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 06.

Predictive Algorithm for Thiopurine-Induced Hepatotoxicity in Inflammatory Bowel Disease Patients.

Autor: van Moorsel SAW; Department of Pharmacy, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.; Department of Clinical Pharmacy, Bernhoven Hospital, Uden, the Netherlands., Deben DS; Departments of Clinical Pharmacy, Clinical Pharmacology and Toxicology and., Creemers RH; Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre, Sittard-Geleen/Heerlen, the Netherlands.; Division of Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, the Netherlands., Winkens B; Department of Methodology and Statistics, Maastricht University Medical Centre, Maastricht, the Netherlands., Bus P; Department of Gastroenterology and Hepatology, Laurentius Hospital, Roermond, the Netherlands; and., Pierik MJ; Division of Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, the Netherlands., Simsek M; Department of Gastroenterology and Hepatology, AGEM Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., de Boer NKH; Department of Gastroenterology and Hepatology, AGEM Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van Bodegraven AA; Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre, Sittard-Geleen/Heerlen, the Netherlands.; Department of Gastroenterology and Hepatology, AGEM Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Wong DR; Departments of Clinical Pharmacy, Clinical Pharmacology and Toxicology and.

Publikováno v: Therapeutic drug monitoring [Ther Drug Monit] 2022 Dec 01; Vol. 44 (6), pp. 747-754.

Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients.

Autor: Deben DS; Department of Clinical Pharmacy, Clinical pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., van Adrichem AJ; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Drent R; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Puts S; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Pelzer KEJM; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., van Bodegraven AA; Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Wong DR; Department of Clinical Pharmacy, Clinical pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Leers MPG; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.

Publikováno v: Cytometry. Part A : the journal of the International Society for Analytical Cytology [Cytometry A] 2022 Feb; Vol. 101 (2), pp. 167-176. Date of Electronic Publication: 2021 Oct 08.