Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Debdeep Dutta"'
Autor:
Jenny Zhe Liao, Hyung-lok Chung, Claire Shih, Kenneth Kin Lam Wong, Debdeep Dutta, Zelha Nil, Catherine Grace Burns, Oguz Kanca, Ye-Jin Park, Zhongyuan Zuo, Paul C. Marcogliese, Katherine Sew, Hugo J. Bellen, Esther M. Verheyen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19. These proteins have been shown to modulate transcriptional control by RNA polymerase II. We found that neuronal loss of Cdk8 severely reduces fly lifespan and causes bang sen
Externí odkaz:
https://doaj.org/article/09c78393720044e6a04bcc50ab0689d0
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage
Externí odkaz:
https://doaj.org/article/5153b7a7cf9f43958af95c0d185f729c
Autor:
Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 11 (2022)
Previously, we described a large collection of Drosophila strains that each carry an artificial exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on CRISPR-mediated homologous recombination. These alleles permit numerous
Externí odkaz:
https://doaj.org/article/21349c0042e4440c9ed944c980a33c8b
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Objectives Oncogenic potential of Notch signaling and its cooperation with other factors to affect proliferation are widely established. Notch exhibits a cooperative effect with loss of a cell polarity gene, scribble to induce neoplastic ove
Externí odkaz:
https://doaj.org/article/b273068f88a84b948b6c78c39da47d2b
Autor:
Ankita Singh, Debdeep Dutta, Maimuna Sali Paul, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 3, Pp 1067-1077 (2018)
Chromatin-remodeling proteins have a profound role in the transcriptional regulation of gene expression during development. Here, we have shown that the chromodomain-containing protein Hat-trick is predominantly expressed within the oocyte nucleus, s
Externí odkaz:
https://doaj.org/article/9487866addae4ffb8865e28f12b4c4a2
Autor:
Shrestha Sinha Ray, Debdeep Dutta, Cassandra Dennys, Samantha Powers, Florence Roussel, Pawel Lisowski, Petar Glažar, Xiaojin Zhang, Pipasha Biswas, Joseph R. Caporale, Nikolaus Rajewsky, Marc Bickle, Nicolas Wein, Hugo J. Bellen, Shibi Likhite, Paul C. Marcogliese, Kathrin C. Meyer
The recently discovered neurological disorder NEDAMSS is caused by heterozygous truncations in the transcriptional regulator IRF2BPL. Here, we reprogram patient skin fibroblasts to astrocytes and neurons to study mechanisms of this newly described di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a92ef0092fbfc6fcdde4c2fadba3fb
http://edoc.mdc-berlin.de/22947/1/22947oa.pdf
http://edoc.mdc-berlin.de/22947/1/22947oa.pdf
Autor:
Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adff038a395a82465a2f97cad773039
https://doi.org/10.7554/elife.76077.sa2
https://doi.org/10.7554/elife.76077.sa2
Autor:
Paul C. Marcogliese, Debdeep Dutta, Shrestha Sinha Ray, Nghi D. P. Dang, Zhongyuan Zuo, Yuchun Wang, Di Lu, Fatima Fazal, Thomas A. Ravenscroft, Hyunglok Chung, Oguz Kanca, JiJun Wan, Emilie D. Douine, Undiagnosed Diseases Network, Loren D. M. Pena, Shinya Yamamoto, Stanley F. Nelson, Matthew Might, Kathrin C. Meyer, Nan Cher Yeo, Hugo J. Bellen
Publikováno v:
Science Advances, vol 8, iss 3
Science Advances
Science Advances
De novo truncations in Interferon Regulatory Factor 2 Binding Protein Like (IRF2BPL) lead to severe childhood-onset neurodegenerative disorders. To determine how loss of IRF2BPL causes neural dysfunction, we examined its function in Drosophila and ze
Autor:
Oguz, Kanca, Jonathan, Zirin, Yanhui, Hu, Burak, Tepe, Debdeep, Dutta, Wen-Wen, Lin, Liwen, Ma, Ming, Ge, Zhongyuan, Zuo, Lu-Ping, Liu, Robert W, Levis, Norbert, Perrimon, Hugo J, Bellen
Publikováno v:
eLife. 11
Previously, we described a large collection of
Publikováno v:
Advances in experimental medicine and biology. 1227
Notch signaling is an evolutionarily conserved pathway that plays a central role in a number of cellular events during metazoan development. Due to its involvement in numerous developmental events, Notch signaling requires tight spatial and temporal