Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Debby P. Chang"'
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 3, Iss 1, Pp 397-403 (2012)
We exploit a series of robust, but simple and convenient colloidal lithography (CL) approaches, using a microsphere array as a mask or as a guiding template, and combine this with surface-initiated atom-transfer radical polymerization (SI-ATRP) to fa
Externí odkaz:
https://doaj.org/article/52cc7569c48b42adbbdb500c0614d615
Autor:
Stijn H.S. Koshari, Linda Jiang, Karthikan Rajagopal, Norman J. Wagner, Xutao Shi, Abraham M. Lenhoff, Debby P. Chang
Publikováno v:
J Pharm Sci
An extensive data set has been developed and used to further the progress of a model-informed design of controlled drug release. An improved drug-release model with mechanistic modeling of hydrolytic polymer degradation is used and validated by compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabc743b243ef5da4187fb1be9e0cb06
https://doi.org/10.1016/j.xphs.2021.09.007
https://doi.org/10.1016/j.xphs.2021.09.007
Autor:
Mohammad Al-Sayah, Dennis Leung, Purnendu K. Nayak, Amin Famili, Debby P. Chang, Meenakshi Goel
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 165:185-192
Poly (lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable polymer, is one of the most commonly used vehicles for controlled-release (CR) implantable dosage forms. Drug molecules formulated in such CR vehicles are released slowly over a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68524ed470988c3fd80ba14f23107f97
https://doi.org/10.1016/j.ejpb.2021.05.008
https://doi.org/10.1016/j.ejpb.2021.05.008
Autor:
Denise E. de Almeida Nagata, Jennifer Vogt, Roxanne Andaya, Helen Booler, Vladimir Bantseev, Chris Schuetz, Chris Lawson, Debby P. Chang
Publikováno v:
Toxicologic Pathology. 49:621-633
Sustained drug delivery formulations are developed to reduce dose frequency while maintaining efficacy of intravitreal (ITV) administered therapeutics. Available safety data for components novel to the eye’s posterior segment may be limited, requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b38c0c483e214753e082c3220193b0a
https://doi.org/10.1177/0192623320971571
https://doi.org/10.1177/0192623320971571
Autor:
Stijn H.S. Koshari, Nathan B Wang, Abraham M. Lenhoff, Karthikan Rajagopal, Isidro E. Zarraga, Norman J. Wagner, Debby P. Chang
Publikováno v:
Journal of Pharmaceutical Sciences. 108:3582-3591
Mathematical modeling of drug release can aid in the design and development of sustained delivery systems, but the parameter estimation of such models is challenging owing to the nonlinear mathematical structure and complexity and interdependency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cc250af5d03a41f1fdd930746208c3
https://doi.org/10.1016/j.xphs.2019.06.027
https://doi.org/10.1016/j.xphs.2019.06.027
Autor:
Debby P. Chang, Joshua Lomeo, Shawn Zhang, Rami N. Hannoush, Karthik Nagapudi, Aiden Zhu, Karthikan Rajagopal
Publikováno v:
Journal of pharmaceutical sciences. 110(10)
Long-acting implants are typically formulated using carrier(s) with specific physical and chemical properties, along with the active pharmaceutical ingredient (API), to achieve the desired daily exposure for the target duration of action. In characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7aafb161c31703512f25bde36ea107b
https://pubmed.ncbi.nlm.nih.gov/34089709
https://pubmed.ncbi.nlm.nih.gov/34089709
Autor:
Chun-Wan Yen, Lu Dai, Steven Chin, Brian Roper, Elizabeth S. Hecht, Chloe Hu, Cadapakam Venkatramani, Nisana Andersen, Robert Kuhn, Dennis Leung, Fiona Lin, Jason Gruenhagen, Christopher M. Crittenden, Alberto Estevez, Mohammad Al-Sayah, Amin Famili, Lance Cadang, Tao Chen, Shijia Tang, Cinzia Stella, Karthik Nagapudi, Peter Yehl, Richard Vandlen, Peter Liu, Alexis Rohou, Debby P. Chang, Rami N. Hannoush
Publikováno v:
Journal of Pharmaceutical Sciences.
Constrained peptides (CPs) have emerged as attractive candidates for drug discovery and development. To fully unlock the therapeutic potential of CPs, it is crucial to understand their physical stability and minimize the formation of aggregates that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e078389a18d4495af32516044ad50a61
https://doi.org/10.1016/j.xphs.2020.12.041
https://doi.org/10.1016/j.xphs.2020.12.041
Publikováno v:
Molecular pharmaceutics. 17(9)
Maintenance of protein stability during manufacture, storage, and delivery is necessary for the successful development of a drug product. Herein, the utility of two compatible solutes-ectoine and hydroxyectoine-in stabilizing a model protein labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a264bf77e312a364291b91b05bce584e
https://pubmed.ncbi.nlm.nih.gov/32672979
https://pubmed.ncbi.nlm.nih.gov/32672979
Autor:
Thierry Nivaggioli, Shalini Burra, Laetitia Comps-Agrar, Karthikan Rajagopal, Eric S. Day, Joyce Chan, Debby P. Chang
Publikováno v:
Journal of pharmaceutical sciences. 110(2)
The port delivery system with ranibizumab (PDS) is an investigational long-acting drug delivery system for the continuous release of ranibizumab, an anti-VEGF biologic, in the vitreous humor. The efficacy of the PDS implant relies on the maintenance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71def2ce9e296893b59625802c7d459f
https://pubmed.ncbi.nlm.nih.gov/33031788
https://pubmed.ncbi.nlm.nih.gov/33031788
Autor:
Lokesh Kumar, Karthik Balakrishna Chandrababu, Shenbaga Moorthy Balakrishnan, Elizabeth M Topp, Debby P. Chang, Isidro E. Zarraga, Andrea Allmendinger, Purnendu K. Nayak, Benjamin T. Walters
Publikováno v:
Molecular pharmaceutics. 16(11)
Solid-state hydrogen-deuterium exchange with mass spectrometry (ssHDX-MS) was evaluated as an analytical method to rapidly screen and select an optimal lyophilized fragment antigen binding protein (Fab) formulation and the optimal lyophilization cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47f157334df7cf12b7eb1e28178a5b3
https://pubmed.ncbi.nlm.nih.gov/31568722
https://pubmed.ncbi.nlm.nih.gov/31568722