Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Debbie Swing"'
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Martin Marsala, Shuying Sun, Ngoc B. Bui, Tsemay M. Tse, Shuo-Chien Ling, Greg Tucker-Kellogg, Gene W. Yeo, Philippe A. Parone, Hristelina Ilieva, Seiya Tokunaga, Christopher Shaw, Sandrine Da Cruz, Oleksandr Platoshyn, Kenneth Lim, Somasish Ghosh Dastidar, Don W. Cleveland, Clotilde Lagier-Tourenne, Debbie Swing, Joo Seok Han, Albert R. La Spada, Anh Bui, Wan Yun Ho, Lino Tessarollo, Jer-Cherng Chang, Melissa McAlonis-Downes, Sheue-Houy Tyan, Anne P. Vetto, Katannya Kapeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6336cbcf1decdbc907883e7a0b14a4f7
https://doi.org/10.7554/elife.40811.039
https://doi.org/10.7554/elife.40811.039
Autor:
Kenneth Lim, Shuying Sun, Sandrine Da Cruz, Debbie Swing, Wan Yun Ho, Philippe A. Parone, Ngoc B. Bui, Jer Cherng Chang, Clotilde Lagier-Tourenne, Joo Seok Han, Albert R. La Spada, Hristelina Ilieva, Anh Bui, Melissa McAlonis-Downes, Katannya Kapeli, Don W. Cleveland, Seiya Tokunaga, Greg Tucker-Kellogg, Martin Marsala, Christopher Shaw, Oleksandr Platoshyn, Somasish Ghosh Dastidar, Tsemay M. Tse, Shuo-Chien Ling, Gene W. Yeo, Sheue Houy Tyan, Lino Tessarollo, Anne P. Vetto
Publikováno v:
Autophagy
eLife, Vol 8 (2019)
eLife
eLife, Vol 8 (2019)
eLife
Coding or non-coding mutations in FUS (fused in sarcoma) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In addition to familial ALS, abnormal aggregates of FUS are present in a portion of FTD and other neurodegenerative
Autor:
Susan Fromholt, Christopher Janus, Debbie Swing, Hilda Brown, David R. Borchelt, Zoe Siemienski, Andrew T.N. Tebbenkamp, Guilian Xu, Lino Tessarollo
Publikováno v:
Journal of Huntington's Disease. 3:73-86
Background: N-terminal cleavage products of mutant huntingtin (htt) generate pathologic neuronal inclusion bodies. The precise length of the htt fragment, termed Cp-A/1, that produces HD pathologic inclusions is unknown. Objective: We sought to eluci
Autor:
Ho Chul Kang, Debbie Swing, Valina L. Dawson, Senthilkumar S. Karuppagounder, Yunjong Lee, Lino Tessarollo, Ted M. Dawson, Byoung Dae Lee, Han Seok Ko, Joo Ho Shin, Yun Il Lee, Sung Ung Kang, Dong-Hoon Kim, Haisong Jiang
Publikováno v:
Nature neuroscience
The defining pathogenic feature of Parkinson’s disease is the age dependent loss of dopaminergic neurons. Mutations and inactivation of parkin, an ubiquitin E3 ligase, cause Parkinson’s disease through accumulation of pathogenic substrates. Here
Autor:
Hilda Brown, Ronald J. Mandel, Cameron Green, Susan Fromholt, David R. Borchelt, Andrew T.N. Tebbenkamp, Debbie Swing, Eileen M. Denovan-Wright, Aaron Rising, Guilian Xu, Lino Tessarollo
Publikováno v:
Human Molecular Genetics. 20:2770-2782
Recent studies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an important mediator of toxicity in Huntington's disease (HD). To directly assess the consequences of such fragments on neurologic function, we pro
Autor:
Yideng Liang, Lee J. Martin, Timothy H. Moran, Naoki Masuda, Debbie Swing, Neal G. Copeland, Zhaohui Liu, Wanli W. Smith, Juan C. Troncoso, Ted M. Dawson, David R. Borchelt, Mikhail V. Pletnikov, Christopher A. Ross, Michael K. Lee, Nancy A. Jenkins
Publikováno v:
Human Molecular Genetics. 19:2087-2098
Genetic alterations in alpha-synuclein cause autosomal dominant familial Parkinsonism and may contribute to sporadic Parkinson's disease (PD). Synphilin-1 is an alpha-synuclein-interacting protein, with implications in PD pathogenesis related to prot
Autor:
Jeannette N. Stankowski, Debbie Swing, Lino Tessarollo, Jonathan C. Grima, Yulan Xiong, Guanxing Chen, Yunjong Lee, Ted M. Dawson, Stewart Neifert, Han Seok Ko, Byoung Dae Lee, Valina L. Dawson, Senthilkumar S. Karuppagounder
Publikováno v:
eNeuro
Visual Abstract
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as an unambiguous cause of late-onset, autosomal-dominant familial Parkinson’s disease (PD) and LRRK2 mutations are the strongest genetic risk fact
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as an unambiguous cause of late-onset, autosomal-dominant familial Parkinson’s disease (PD) and LRRK2 mutations are the strongest genetic risk fact
Autor:
Melissa McAlonis-Downes, Martin Marsala, Debbie Swing, Sandrine Da Cruz, Philippe A. Parone, Dara Ditsworth, Clotilde Lagier-Tourenne, Gene W. Yeo, Holly B. Kordasiewicz, Oleksandr Platoshyn, Christopher Shaw, Magdalini Polymenidou, Lino Tessarollo, Eveline S. Arnold, Kevin M. Clutario, Stephanie C. Huelga, Shuo-Chien Ling, Don W. Cleveland
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Transactivating response region DNA binding protein (TDP-43) is the major protein component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with ubiquitinated inclusions. Two ALS-c
Autor:
Valina L. Dawson, Lino Tessarollo, Ho Chul Kang, Dong-Hoon Kim, Yunjong Lee, Byoung Dae Lee, Sung Ung Kang, Han Seok Ko, Debbie Swing, Yun Il Lee, Haisong Jiang, Ted M. Dawson, Joo Ho Shin, Senthilkumar S. Karuppagounder
Publikováno v:
Nature Neuroscience. 18:1861-1861
Nat. Neurosci. 16, 1392–1400 (2013); published online 25 August 2013; corrected after print 1 June 2015 In the version of this article initially published, the image in Figure 2c described as being from 20-month-old transgenic mice was actually fro