Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Debbie S. Ruelas"'
Autor:
Saša Stefanić, Jan Dvořák, Martin Horn, Simon Braschi, Daniel Sojka, Debbie S Ruelas, Brian Suzuki, Kee-Chong Lim, Stephanie D Hopkins, James H McKerrow, Conor R Caffrey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 10, p e850 (2010)
BACKGROUND: The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has
Externí odkaz:
https://doaj.org/article/b17f96117a3c4d56992f95c9942acc85
Autor:
Maha-Hamadien Abdulla, Debbie S Ruelas, Brian Wolff, June Snedecor, Kee-Chong Lim, Fengyun Xu, Adam R Renslo, Janice Williams, James H McKerrow, Conor R Caffrey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e478 (2009)
BackgroundPraziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics. Identification of anti-schistosomal chemicals has traditionally relied o
Externí odkaz:
https://doaj.org/article/e07426d1155142edb442dafbc6846ea9
Autor:
Warner C. Greene, Isa Muñoz-Arias, Debbie S. Ruelas, Gilad Doitsh, Zhiyuan Yang, Stefanie Sowinski
Publikováno v:
Cell host & microbe, vol 18, iss 4
SummaryProgression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissues. Inefficient reverse transcription in these cells leads to cytoplasmic accumulation of vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a1dc4cac54c1947a8f90e77b4a96e1
https://europepmc.org/articles/PMC4627664/
https://europepmc.org/articles/PMC4627664/
Autor:
Michael Rape, Debbie S. Ruelas, Jonathan K.L. Chan, Leonard Chavez, Andrew M. Hebbeler, Amy Heidersbach, Warner C. Greene, Eugene Oh, Eric Verdin
Publikováno v:
The Journal of biological chemistry, vol 290, iss 22
The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4795ca0502b9b072ee0cc7cc4db8dc44
https://escholarship.org/uc/item/199690sw
https://escholarship.org/uc/item/199690sw
Publikováno v:
Journal of Invertebrate Pathology. 93:192-200
Although Schistosoma mansoni occurs mainly in the tropics, where intense levels of solar radiation are present, the impact of ultraviolet (UV) light on schistosome transmission is not known. The purpose of this study was to investigate potential effe
Autor:
Warner C. Greene, Debbie S. Ruelas
Publikováno v:
Cell, vol 155, iss 3
Despite significant advances in our understanding of HIV, a cure has not been realized for the more than 34 million infected with this virus. HIV is incurable because infected individuals harbor cells where the HIV provirus is integrated into the hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937fe49b74938fa6acd8ad62e72f34df
https://escholarship.org/uc/item/3443v00f
https://escholarship.org/uc/item/3443v00f
Autor:
Jonathan Ch Chan, Christopher H. Woelk, Sharon R Lewin, Robert F. Siliciano, Angela D. M. Kashuba, Stacey L Wooden, Akul Singhania, Sifei Xing, Celsa A. Spina, Matthew J. Mau, David M. Margolis, Alberto Bosque, Warner C. Greene, Marylinda Famiglietti, Nancie M. Archin, Debbie S. Ruelas, Vicente Planelles, Jenny L. Anderson, Kotaro Shirakawa, Eric Verdin, Valeri H. Terry, Suha Saleh, Paula C. Soto
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003834 (2013)
PLoS Pathogens
PLoS Pathogens
The possibility of HIV-1 eradication has been limited by the existence of latently infected cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have been hindered by the small numbers of latently infected cells f
Autor:
K. C. Lim, Debbie S. Ruelas, Laura Lambeth, Jessica R. Ingram, Ivy Hsieh, Salma B. Rafi, Judy A. Sakanari, Charles S. Craik, James H. McKerrow, Alegra Eroy-Reveles, Manisha Ray, Matthew P. Jacobson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1589 (2012)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background Cercarial elastase is the major invasive larval protease in Schistosoma mansoni, a parasitic blood fluke, and is essential for host skin invasion. Genome sequence analysis reveals a greatly expanded family of cercarial elastase gene isofor
Autor:
James H. McKerrow, Stephanie D. Hopkins, Jan Dvořák, Saša Štefanić, Brian M. Suzuki, Debbie S. Ruelas, Simon Braschi, Daniel Sojka, Martin Horn, Conor R. Caffrey, K. C. Lim
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 4, Iss 10, p e850 (2010)
PLoS neglected tropical diseases, vol 4, iss 10
PLoS Neglected Tropical Diseases, Vol 4, Iss 10, p e850 (2010)
PLoS neglected tropical diseases, vol 4, iss 10
Background The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has
Autor:
Conor R. Caffrey, Debbie S. Ruelas, Maha-Hamadien Abdulla, Kee Chong Lim, Fengyun Xu, James H. McKerrow, Janice Williams, Adam R. Renslo, June Snedecor, Brian Wolff
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e478 (2009)
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, vol 3, iss 7
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, vol 3, iss 7
Background Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics. Identification of anti-schistosomal chemicals has traditionally relied