Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Debbie M. Ferns"'
Autor:
Sanne Samuels, Tanja D. de Gruijl, Debbie M. Ferns, A. Marijne Heeren, Maaike C. G. Bleeker, Gemma G. Kenter, Ekaterina S. Jordanova
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells by downregulation of classical human leukocyte antigens (HLA) and overexpression of non-classical HLA. This is the first study to investigate HLA expression
Externí odkaz:
https://doaj.org/article/09b2f246652646ba8f3a8dc9b5326634
Autor:
Tanja D. de Gruijl, Ekaterina S. Jordanova, Gemma G. Kenter, Dafni Chondronasiou, Debbie M. Ferns, Sanne Samuels, Bas D. Koster, A. Marijne Heeren
Triple immunofluorescence staining of CD14 (green), CD163 (red) and PD-L1 (blue) of representative tumor negative (LN-) and positive (LN+) lymph node specimen reveals the presence of elevated numbers of CD14+CD163+ cells expressing PD-L1 in LN+ and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315d713f0c6f6bba5b749b886cb86a62
https://doi.org/10.1158/2326-6066.22537805
https://doi.org/10.1158/2326-6066.22537805
Autor:
Tanja D. de Gruijl, Ekaterina S. Jordanova, Gemma G. Kenter, Dafni Chondronasiou, Debbie M. Ferns, Sanne Samuels, Bas D. Koster, A. Marijne Heeren
A better understanding of the microenvironment in relation to lymph node metastasis is essential for the development of effective immunotherapeutic strategies against cervical cancer. In the present study, we investigated the microenvironment of tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450a3099650ce6826184f19654a70796
https://doi.org/10.1158/2326-6066.c.6548555.v1
https://doi.org/10.1158/2326-6066.c.6548555.v1
Autor:
Sanne Samuels, M.R. Buist, Henry Zijlmans, Ekaterina S. Jordanova, J.P. van Straalen, Gemma G. Kenter, Debbie M. Ferns, D. Meijer
Publikováno v:
Tissue Antigens. 85:476-483
Downregulation of major histocompatibility complex class I chain-related molecule A (MICA) and upregulation of human leukocyte antigen G (HLA-G) on the tumor cells are important immune escape mechanisms for different epithelial tumors. In addition, u
Autor:
Maaike C G Bleeker, Tanja D. de Gruijl, Debbie M. Ferns, A. Marijne Heeren, Gemma G. Kenter, Ekaterina S. Jordanova, Sanne Samuels
Publikováno v:
Journal for Immunotherapy of Cancer, 4. BioMed Central
Ferns, D M, Heeren, A M, Samuels, S, Bleeker, M C G, de Gruijl, T D, Kenter, G G & Jordanova, E S 2016, ' Classical and non-classical HLA class I aberrations in primary cervical squamous-and adenocarcinomas and paired lymph node metastases ', Journal for Immunotherapy of Cancer, vol. 4 . https://doi.org/10.1186/s40425-016-0184-3
Journal for immunotherapy of cancer, 4. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Ferns, D M, Heeren, A M, Samuels, S, Bleeker, M C G, de Gruijl, T D, Kenter, G G & Jordanova, E S 2016, ' Classical and non-classical HLA class I aberrations in primary cervical squamous-and adenocarcinomas and paired lymph node metastases ', Journal for Immunotherapy of Cancer, vol. 4 . https://doi.org/10.1186/s40425-016-0184-3
Journal for immunotherapy of cancer, 4. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Background Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells by downregulation of classical human leukocyte antigens (HLA) and overexpression of non-classical HLA. This is the first study to investigate HLA expression
Autor:
Marrije R. Buist, Debbie M. Ferns, Ido P. Kema, Ekaterina S. Jordanova, Gemma G. Kenter, Hans W. Nijman
Publikováno v:
OncoImmunology, 4(2):e981457. Landes Bioscience
Oncoimmunology, 4(2). Landes Bioscience
OncoImmunology, 4(2):981457. Taylor & Francis Group
Ferns, D M, Kema, I P, Buist, M R, Nijman, H W, Kenter, G G & Jordanova, E S 2015, ' Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival ', OncoImmunology, vol. 4, no. 2, e981457 . https://doi.org/10.4161/2162402X.2014.981457
Oncoimmunology, 4(2). Landes Bioscience
OncoImmunology, 4(2):981457. Taylor & Francis Group
Ferns, D M, Kema, I P, Buist, M R, Nijman, H W, Kenter, G G & Jordanova, E S 2015, ' Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival ', OncoImmunology, vol. 4, no. 2, e981457 . https://doi.org/10.4161/2162402X.2014.981457
The expression of the immunomodulating enzyme indoleamine-2,3-dioxygenase (IDO) suppresses T-lymphocyte function, thus correlating with poor survival in a variety of cancer patients. IDO degrades the essential amino acid tryptophan leading to immunos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f708867029e92a33a0c0fa6848f6a3
https://research.vumc.nl/en/publications/e93df455-855e-440f-9d7c-100efe0bc40d
https://research.vumc.nl/en/publications/e93df455-855e-440f-9d7c-100efe0bc40d
Autor:
Debbie M. Ferns, Sanne Samuels, Dafni Chondronasiou, Gemma G. Kenter, Ekaterina S. Jordanova, Bas D. Koster, A. Marijne Heeren, Tanja D. de Gruijl
Publikováno v:
Heeren, A M, Koster, B D, Samuels, S, Ferns, D M, Chondronasiou, D, Kenter, G G, Jordanova, E S & de Gruijl, T D 2015, ' High and Interrelated Rates of PD-L1(+)CD14(+) Antigen-Presenting Cells and Regulatory T Cells Mark the Microenvironment of Metastatic Lymph Nodes from Patients with Cervical Cancer ', Cancer Immunology Research, vol. 3, no. 1, pp. 48-58 . https://doi.org/10.1158/2326-6066.CIR-14-0149
Cancer immunology research, 3(1), 48-58. American Association for Cancer Research Inc.
Cancer Immunology Research, 3(1), 48-58. American Association for Cancer Research Inc.
Cancer immunology research, 3(1), 48-58. American Association for Cancer Research Inc.
Cancer Immunology Research, 3(1), 48-58. American Association for Cancer Research Inc.
A better understanding of the microenvironment in relation to lymph node metastasis is essential for the development of effective immunotherapeutic strategies against cervical cancer. In the present study, we investigated the microenvironment of tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d3f819e6edf37b0c1e9f768e12263c
https://research.vumc.nl/en/publications/44464971-8374-4cd6-b191-889b5dca5948
https://research.vumc.nl/en/publications/44464971-8374-4cd6-b191-889b5dca5948
Autor:
Bas D. Koster, Marijne Heeren, Gemma G. Kenter, Ekaterina S. Jordanova, Debbie M. Ferns, Sanne Samuels, Dafni Chondronasiou, Tanja D. de Gruijl
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts A better understanding of the microenvironment in relation to lymph node metastasis is essential for the development of effective immunotherapeutic strategies against cervical cancer. In the present study, we investigated the microe