Výsledky vyhledávání - "Debbie L Lang"

Akademický článek

Combination of low calcium with Y-27632 rock inhibitor increases the proliferative capacity, expansion potential and lifespan of primary human keratinocytes while retaining their capacity to differentiate into stratified epidermis in a 3D skin model.

Autor: Xanthe L Strudwick, Debbie L Lang, Louise E Smith, Allison J Cowin

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123651 (2015)

Human keratinocytes are difficult to isolate and have a limited lifespan. Traditionally, immortalised keratinocyte cell lines are used in vitro due to their ability to bypass senescence and survive indefinitely. However these cells do not fully retai

Externí odkaz: https://doaj.org/article/521d93d846ee4fa3824aebbc97d27fe1

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Combination of low calcium with Y-27632 rock Inhibitor increases the proliferative capacity, expansion potential and lifespan of primary human keratinocytes while retaining their capacity to differentiate into stratified epidermis in a 3D skin model

Autor: Louise E. Smith, Allison J. Cowin, Debbie L. Lang, Xanthe L. Strudwick

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123651 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e057d794cc588142c4c0b6c68e53c2
https://hdl.handle.net/11541.2/115018

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Screening patients referred to a metabolic clinic for lysosomal storage disorders

Autor: Maria Fuller, Peter J. Meikle, Debbie L. Lang, Michael Fietz, Justin N. Tucker, Caroline J. Dean, John Joseph Hopwood

Publikováno v: Journal of medical genetics. 48(6)

Background Lysosomal protein profiling is being developed as a high throughput method to screen populations for lysosomal storage disorders (LSD). Design 1415 blood spots from patients referred to a metabolic clinic for LSD were screened using a sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7747b1d1d3f5f22dafb6889d5c61b2
https://pubmed.ncbi.nlm.nih.gov/21415080

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Effect of cisternal sulfamidase delivery in MPS IIIA Huntaway dogs--a proof of principle study

Autor: John J. Hopwood, Robert D. Jolly, Kim M. Hemsley, Barbara King, Dyane Auclair, Debbie L. Lang, Elizabeth J. Norman, Caroline J. Dean, Allison C. Crawley, Maria Fuller

Publikováno v: Molecular genetics and metabolism. 98(4)

Mucopolysaccharidosis type IIIA (MPS IIIA) results from lack of functional sulfamidase (SGSH), a lysosomal enzyme. Its substrate, heparan sulfate, and other secondarily-stored compounds subsequently accumulate primarily within the central nervous sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27176fbd5edfd3938f26ecbf3c1bd37e
https://pubmed.ncbi.nlm.nih.gov/19699666

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Stabilising normal and mis-sense variant alpha-glucosidase

Autor: Revecca Kakavanos, Debbie L. Lang, Doug A. Brooks, Peter J. Meikle, John J. Hopwood

Publikováno v: FEBS letters. 580(18)

alpha-Glucosidase (EC 3.2.1.3) is a lysosomal enzyme that hydrolyses alpha-1,4- and alpha-1,6-linkages of glycogen to produce free glucose. A deficiency in alpha-glucosidase activity results in glycogen storage disorder type II (GSD II), also called

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14005b7ccd435163e0092efd05c7233
https://pubmed.ncbi.nlm.nih.gov/16846599

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Newborn screening for lysosomal storage disorders

Autor: John J. Hopwood, Dallas J. Grasby, Douglas A. Brooks, Michael Fietz, Henrik Simonsen, Alison M. Whittle, Michelle Bockmann, Caroline J. Dean, Debbie L. Lang, Peter J. Meikle, Maria Fuller

Publikováno v: Molecular genetics and metabolism. 88(4)

Lysosomal storage disorders (LSD) are chronic progressive diseases that have a devastating impact on the patient and family. Most patients are clinically normal at birth but develop symptoms early in childhood. Despite no curative treatment, a number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad3e6ac229577c0e99545ac71e5af08
https://pubmed.ncbi.nlm.nih.gov/16600651

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