Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Debbie L Cunningham"'
Autor:
Debbie L Cunningham, Andrew J Creese, Giulio Auciello, Steve M M Sweet, Tulin Tatar, Joshua Z Rappoport, Melissa M Grant, John K Heath
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61513 (2013)
Eps8 is involved in both cell signalling and receptor trafficking. It is a known phosphorylation substrate for two proteins involved in the fibroblast growth factor receptor (FGFR) signalling pathway: the receptor itself and Src. Here we report a dif
Externí odkaz:
https://doaj.org/article/e655224b4683456292e217457d30eff3
Autor:
Angelos Papadopoulos, Varvara Chalmantzi, Olga Mikhaylichenko, Marko Hyvönen, Dimitris Stellas, Aditi Kanhere, John Heath, Debbie L. Cunningham, Theodore Fotsis, Carol Murphy
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102133- (2021)
Human embryonic stem cells (hESCs) are an invaluable tool in the fields of embryology and regenerative medicine. Activin A and BMP4 are well-characterised growth factors implicated in pluripotency and differentiation. In the current study, hESCs are
Externí odkaz:
https://doaj.org/article/05f71f6998cd45eeb58cad3f9e82c687
Autor:
Adil R. Sarhan, Justyna Szyroka, Shabana Begum, Michael G. Tomlinson, Neil A. Hotchin, John K. Heath, Debbie L. Cunningham
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The Platelet Derived Growth Factor (PDGF) family of ligands have well established functions in the induction of cell proliferation and migration during development, tissue homeostasis and interactions between tumours and stroma. However, the
Externí odkaz:
https://doaj.org/article/0b0dbe9723e34b89ad5ea75b59b2f907
Autor:
José Luis Marín-Rubio, Laura Vela-Martín, Jack Gudgeon, Eduardo Pérez-Gómez, Frances R. Sidgwick, Matthias Trost, Debbie L. Cunningham, Javier Santos, José Fernández-Piqueras, María Villa-Morales
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15157
A reduction in FADD levels has been reported in precursor T-cell neoplasms and other tumor types. Such reduction would impact on the ability of tumor cells to undergo apoptosis and has been associated with poor clinical outcomes. However, FADD is als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86dc15180195a2cd73bf1906987520a8
Publikováno v:
Journal of proteome research. 21(4)
Protein post-translational modifications (PTMs) enable cells to rapidly change in response to biological stimuli. With hundreds of different PTMs, understanding these control mechanisms is complex. To date, efforts have focused on investigating the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2f918b9259c13ece424df966589662
https://pubmed.ncbi.nlm.nih.gov/35235327
https://pubmed.ncbi.nlm.nih.gov/35235327
Autor:
Helen J. Cooper, Katie Brookes, Andrew J. Creese, Harriet R. Ferguson, Hongyan Zhao, John K. Heath, Katherine P. B. Larkins, Anna A. Marusiak, Debbie L. Cunningham, Adil R. Sarhan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Fibroblast Growth Factor (FGF) dependent signalling is frequently activated in cancer by a variety of different mechanisms. However, the downstream signal transduction pathways involved are poorly characterised. Here a quantitative differential phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747c65f57140163ab2b08b9b528cd3d0
https://pubmed.ncbi.nlm.nih.gov/32409632
https://pubmed.ncbi.nlm.nih.gov/32409632
Autor:
Varvara Chalmantzi, Angelos Papadopoulos, Marko Hyvönen, Dimitris Stellas, Debbie L. Cunningham, Carol Murphy, Aditi Kanhere, Theodore Fotsis, Olga Mikhaylichenko, John K. Heath
Publikováno v:
Stem Cell Research, Vol 50, Iss, Pp 102133-(2021)
Human embryonic stem cells (hESCs) are an invaluable tool in the fields of embryology and regenerative medicine. Activin A and BMP4 are well-characterised growth factors implicated in pluripotency and differentiation. In the current study, hESCs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5362a4e24df6679d457a128fb230d5
https://doi.org/10.1016/j.scr.2020.102133
https://doi.org/10.1016/j.scr.2020.102133
Publikováno v:
Journal of Cell Science. 126:613-624
Summary Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development and wound healing. However, aberrant FGFR activity leads to cancer. Activated growth factor receptors undergo stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f18137dca831416d2f0c93893f8b136
https://doi.org/10.1242/jcs.116228
https://doi.org/10.1242/jcs.116228
Autor:
Adil R, Sarhan, Justyna, Szyroka, Shabana, Begum, Michael G, Tomlinson, Neil A, Hotchin, John K, Heath, Debbie L, Cunningham
Publikováno v:
Scientific Reports
The Platelet Derived Growth Factor (PDGF) family of ligands have well established functions in the induction of cell proliferation and migration during development, tissue homeostasis and interactions between tumours and stroma. However, the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7333c26dc326d575efb7b083c8fc3a67
https://pubmed.ncbi.nlm.nih.gov/28638064
https://pubmed.ncbi.nlm.nih.gov/28638064
Autor:
Neil A. Hotchin, Trushar R. Patel, Alana R. Cowell, Debbie L. Cunningham, Adil R. Sarhan, Michael G. Tomlinson, Carina Hellberg, John K. Heath
Publikováno v:
Journal of cell science. 129(15)
Focal adhesions are complex multi-molecular structures that link the actin cytoskeleton to the extracellular matrix through integrin adhesion receptors and play a key role in regulation of many cellular functions. LAR (also known as PTPRF) is a recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594faf7f06aa977ea52eb5acb51b98c2
https://pubmed.ncbi.nlm.nih.gov/27352860
https://pubmed.ncbi.nlm.nih.gov/27352860