Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Debbie Hsu"'
Autor:
Bryan A. Kramer, Kevin Whelan, Yoshinori Sekiguchi, Shigeyuki Chaki, Pureza Vallar, Michael Morgan, Graeme Semple, Thuy-Anh Tran, William Thomsen, Dipanjan Sengupta, Juyi Choi, Debbie Hsu, Andrew J. Grottick, Kosuke Kanuma, Erin K. Hauser, Ning Zou, Martin Casper, Sangdon Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6166-6171
A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was not
Autor:
Bill Thomsen, Mariko Nishiguchi, Debbie Hsu, Graeme Semple, Katsunori Omodera, Bryan A. Kramer, Kosuke Kanuma, Takeo Funakoshi, Martin Casper, Thuy-Anh Tran, Yoshinori Sekiguchi, Shigeyuki Chaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3853-3856
The optimization of a series of 4-(dimethylamino)quinazoline antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. The combination of the elaboration of both the linker portion and the terminal phenyl ring provided N-(cis
Autor:
Debbie Hsu, Thuy-Anh Tran, Nigel Robert Arnold Beeley, Kosuke Kanuma, Bill Thomsen, Mariko Nishiguchi, Graeme Semple, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Bryan A. Kramer, Katsunori Omodera, Martin Casper
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(10)
A series of 4-(dimethylamino)quinazoline based antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. This series was derived from a lead compound, AR129330, identified by HTS of a GPCR-directed library using a functional