Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Debbie Hicks†"'
Autor:
Claire Keeling, Simon Davies, Jack Goddard, Vijay Ramaswamy, Edward C. Schwalbe, Simon Bailey, Debbie Hicks, Steven C. Clifford
Publikováno v:
EClinicalMedicine, Vol 69, Iss , Pp 102469- (2024)
Summary: Background: Medulloblastoma patients with a sub-total surgical resection (STR; >1.5 cm2 primary tumour residuum post-surgery) typically receive intensified treatment. However, the association of STR with poor outcomes has not been observed c
Externí odkaz:
https://doaj.org/article/8aac62da82144c32925d2195f0158088
Autor:
Sarah Kohe, Christopher Bennett, Florence Burté, Magretta Adiamah, Heather Rose, Lara Worthington, Fatma Scerif, Lesley MacPherson, Simrandip Gill, Debbie Hicks, Edward C. Schwalbe, Stephen Crosier, Lisa Storer, Ambarasu Lourdusamy, Dipyan Mitra, Paul S. Morgan, Robert A. Dineen, Shivaram Avula, Barry Pizer, Martin Wilson, Nigel Davies, Daniel Tennant, Simon Bailey, Daniel Williamson, Theodoros N. Arvanitis, Richard G. Grundy, Steven C. Clifford, Andrew C. Peet
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104958- (2024)
Summary: Background: The malignant childhood brain tumour, medulloblastoma, is classified clinically into molecular groups which guide therapy. DNA-methylation profiling is the current classification ‘gold-standard’, typically delivered 3–4 wee
Externí odkaz:
https://doaj.org/article/7ea57b301d434c53922cf4908ce48606
Autor:
Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling ma
Externí odkaz:
https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
Autor:
Jack Goddard, Jemma Castle, Emily Southworth, Anya Fletcher, Stephen Crosier, Idoia Martin-Guerrero, Miguel García-Ariza, Aurora Navajas, Julien Masliah-Planchon, Franck Bourdeaut, Christelle Dufour, Olivier Ayrault, Tobias Goschzik, Torsten Pietsch, Martin Sill, Stefan M. Pfister, Stefan Rutkowski, Stacey Richardson, Rebecca M. Hill, Daniel Williamson, Simon Bailey, Edward C. Schwalbe, Steven C. Clifford, Debbie Hicks
Publikováno v:
Acta Neuropathologica. 145:651-666
Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MBGrp4 molecular substructures have been identified (e.g. subgroups/cytogenetics/mutations), howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31310920651d70af98043527424bb4d7
https://doi.org/10.1007/s00401-023-02566-0
https://doi.org/10.1007/s00401-023-02566-0
Autor:
Elizabeth Harris, Ana Topf, Rita Barresi, Judith Hudson, Helen Powell, James Tellez, Debbie Hicks, Anna Porter, Marta Bertoli, Teresinha Evangelista, Chiara Marini-Betollo, Ólafur Magnússon, Monkol Lek, Daniel MacArthur, Kate Bushby, Hanns Lochmüller, Volker Straub
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-12 (2017)
Abstract Background Limb girdle muscular dystrophies are a group of rare and genetically heterogeneous diseases that share proximal weakness as a common feature; however they are often lacking very specific phenotypic features to allow an accurate di
Externí odkaz:
https://doaj.org/article/756157a86465454187677c275a3b7caf
Autor:
Marina Danilenko, Masood Zaka, Claire Keeling, Stephen Crosier, Stephanie Lyman, Martina Finetti, Daniel Williamson, Rafiqul Hussain, Jonathan Coxhead, Peixun Zhou, Rebecca M. Hill, Debbie Hicks, Vikki Rand, Abhijit Joshi, Edward C. Schwalbe, Simon Bailey, Steven C. Clifford
We reconstructed the natural history and temporal evolution of the most common childhood brain malignancy, medulloblastoma, by single-cell whole-genome sequencing (sc-WGS) of tumours representing its major molecular sub-classes and clinical risk grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6652e5b40f6a83ad786dfd700d3915c7
https://nrl.northumbria.ac.uk/id/eprint/49790/8/s00401-022-02464-x.pdf
https://nrl.northumbria.ac.uk/id/eprint/49790/8/s00401-022-02464-x.pdf
Autor:
Daniel Williamson, Edward C Schwalbe, Debbie Hicks, Kimberly A Aldinger, Janet C Lindsey, Stephen Crosier, Stacey Richardson, Jack Goddard, Rebecca M Hill, Jemma Castle, Yura Grabovska, James Hacking, Barry Pizer, Stephen B Wharton, Thomas S Jacques, Abhijit Joshi, Simon Bailey, Steven C Clifford
SummaryMedulloblastoma is currently sub-classified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA-seq in large well annotated cohorts of medulloblastoma we show that transcriptionally Group3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a23c77ecac48c103e0e60126a975bf
https://doi.org/10.1101/2022.06.09.495353
https://doi.org/10.1101/2022.06.09.495353
Autor:
Jim Moore, Sarah Davies, Marc Evans, Debbie Hicks, Dipesh E Patel, Ketan Dhatariya, Zaheer Yousef, Umesh Dashora, Bethany Kelly, Philip Newland-Jones, Sharlene A. Greenwood, Angharad R. Morgan
Publikováno v:
Diabetes Therapy
Early diagnosis and effective management of type 2 diabetes (T2D) are crucial in reducing the risk of developing life-changing complications such as heart failure, stroke, kidney disease, blindness and amputation, which are also associated with signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e6c22d11bbf518656ff9892ddd75a1
https://doi.org/10.1007/s13300-020-00963-2
https://doi.org/10.1007/s13300-020-00963-2
Autor:
June James, Debbie Hicks
Publikováno v:
Practical Diabetes. 37:173-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e6799a74fa621f0e02acc2134dfedd0
https://doi.org/10.1002/pdi.2296
https://doi.org/10.1002/pdi.2296
Autor:
Philip Newland-Jones, Amar Ali, Dipesh E Patel, Debbie Hicks, Adie Viljoen, Marc Evans, June James, Kevin Fernando, David C. Wheeler, John P.H. Wilding, Nicola Milne
Publikováno v:
Diabetes Therapy
Diabetic kidney disease (DKD) is a topic of increasing concern among clinicians involved in the management of type 2 diabetes mellitus (T2DM). It is a progressive and costly complication associated with increased risk of adverse cardiovascular (CV) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2201e2bbd1fd731cddaf9979e9b2aa4e
http://europepmc.org/articles/PMC7524028
http://europepmc.org/articles/PMC7524028