Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis

Autor: Debbie H. Svendsrud, Trond Stokke, Gunnar Brunborg, Jostein Dahle, Egil Kvam

Publikováno v: Cancer Letters. 267:18-25

7,8-dihydro-8-oxo-guanine (8-oxoG) is a mutagenic DNA lesion that is induced by ultraviolet A (UVA) radiation. 8-oxoG results in increased frequency of GC-->TA transversion mutations. UVA-induced mutant frequency was measured in the guanine phosphori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be246ae3c3e3bb291314118762000c70
https://doi.org/10.1016/j.canlet.2008.03.002

Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas

Autor: E A Sivertsen, David Mu, Stine H. Kresse, Paula M. DeAngelis, Debbie H. Svendsrud, L. Smedshammer, Eivind Galteland, Leonardo A. Meza-Zepeda, Ola Myklebost, Zhenhe Suo, Trond Stokke

Publikováno v: Leukemia. 19:2313-2323

Gain of chromosome 18q and translocation t(14;18) are] frequently found in B-cell non-Hodgkin's lymphomas (B-NHL). Increased BCL2 transcription and BCL2 protein expression have been suggested to be the result of the gain. We utilized FISH, PCR and ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daa10124bc32c6660f6183640d88733
https://doi.org/10.1038/sj.leu.2403954

Nickel(II) induces microsatellite mutations in human lung cancer cell lines

Autor: David Ryberg, Shanbeh Zienolddiny, Aase B Mikalsen, Debbie H. Svendsrud, Aage Haugen

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 452:91-100

Nickel(II) is a human carcinogen causing respiratory cancers. The purpose of this study was to determine whether Ni(II) may induce microsatellite mutations in human cells. We transfected the three human lung tumor cell lines A427, HCC15 and NCI-H2009

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283757b10fcd36e04a117e1dfc84cc5a
https://doi.org/10.1016/s0027-5107(00)00060-9

Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer

Autor: Trevor Clancy, Kolbein Sundfør, Debbie H. Svendsrud, Malin Lando, Heidi Lyng, Ruth Holm, Cathinka Halle, Marit Holden, Gunnar B. Kristensen

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 17(16)

Purpose: We compared the prognostic significance of ectodomain isoforms of the epidermal growth factor receptor (EGFR), which lack the tyrosine kinase (TK) domain, with that of the full-length receptor and its autophosphorylation status in cervical c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504e8c825a331c64c04a9cc278086577
https://pubmed.ncbi.nlm.nih.gov/21737508

Genome-wide estimation of transcript concentrations from spotted cDNA microarray data

Autor: Marit Holden, Ingrid K. Glad, Debbie H. Svendsrud, Heidi Lyng, Mark A. van de Wiel, Arnoldo Frigessi

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 33(17):e143, 1-13. Oxford University Press
Frigessi, A, van de Wiel, M A, Holden, M, Svendsrud, D H, Glad, I K & Lyng, H 2005, ' Genome-wide estimation of transcript concentrations from spotted cDNA microarray data ', Nucleic Acids Research, vol. 33, no. 17, e143, pp. 1-13 . https://doi.org/10.1093/nar/gni141
Nucleic Acids Research-Methods Online, 33(17)

A method providing absolute transcript concentrations from spotted microarray intensity data is presented. Number of transcripts per microg total RNA, mRNA or per cell, are obtained for each gene, enabling comparisons of transcript levels within and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819134f75f4a1f3d37154fe190ea89f2
https://doi.org/10.1093/nar/gni141