Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Debbie Goh"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Since the discovery of induced pluripotent stem cell (iPSC) technology, there have been many attempts to create cellular models of inherited retinal diseases (IRDs) for investigation of pathogenic processes to facilitate target discovery and validati
Externí odkaz:
https://doaj.org/article/f7fbb9bbb61f4c0bb1c4db49bfb1b54c
Autor:
Swathi Lingam, Zengping Liu, Binxia Yang, Wendy Wong, Bhav Harshad Parikh, Jun Yi Ong, Debbie Goh, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Gavin S. W. Tan, Graham E. Holder, Kakkad Regha, Veluchamy Amutha Barathi, Walter Hunziker, Gopal Lingam, Xianmin Zeng, Xinyi Su
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor pr
Externí odkaz:
https://doaj.org/article/ebb00a72f8324335bf6cabbb07433c97
Autor:
Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109022- (2021)
Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which mu
Externí odkaz:
https://doaj.org/article/f2a1aa9c1fb544b5b5376bb03b90e605
Autor:
Paul V. Waldron, Fabiana Di Marco, Kamil Kruczek, Joana Ribeiro, Anna B. Graca, Claire Hippert, Nozie D. Aghaizu, Aikaterini A. Kalargyrou, Amanda C. Barber, Giulia Grimaldi, Yanai Duran, Samuel J.I. Blackford, Magdalena Kloc, Debbie Goh, Eduardo Zabala Aldunate, Robert D. Sampson, James W.B. Bainbridge, Alexander J. Smith, Anai Gonzalez-Cordero, Jane C. Sowden, Robin R. Ali, Rachael A. Pearson
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 406-421 (2018)
Summary: Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photoreceptors can restore visual function in models of inherited blindness, a process previously underst
Externí odkaz:
https://doaj.org/article/9c09c8d9a3254109b4487e9be40e1549
Autor:
Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J.I. Blackford, Laura Abelleira-Hervas, Robert D. Sampson, Ian O. Shum, Matthew J. Branch, Peter J. Gardner, Jane C. Sowden, James W.B. Bainbridge, Alexander J. Smith, Emma L. West, Rachael A. Pearson, Robin R. Ali
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 820-837 (2017)
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that
Externí odkaz:
https://doaj.org/article/8a49ca1b0cdf4a038147dab24006d255
Autor:
Kamil Kruczek, Anai Gonzalez-Cordero, Debbie Goh, Arifa Naeem, Mindaugas Jonikas, Samuel J.I. Blackford, Magdalena Kloc, Yanai Duran, Anastasios Georgiadis, Robert D. Sampson, Ryea N. Maswood, Alexander J. Smith, Sarah Decembrini, Yvan Arsenijevic, Jane C. Sowden, Rachael A. Pearson, Emma L. West, Robin R. Ali
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1659-1674 (2017)
The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retinas derived f
Externí odkaz:
https://doaj.org/article/4b46b88060114033ab080d3c4bf48091
Autor:
Aaron Tan, Debbie Goh, Yasmin Farhatnia, Natasha G, Jing Lim, Swee-Hin Teoh, Jayakumar Rajadas, Mohammad S Alavijeh, Alexander M Seifalian
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77112 (2013)
In situ endothelialization of cardiovascular implants has emerged in recent years as an attractive means of targeting the persistent problems of thrombosis and intimal hyperplasia. This study aimed to investigate the efficacy of immobilizing anti-CD3
Externí odkaz:
https://doaj.org/article/06223a95f9ee42b297850079221bd57c
Autor:
Debbie Goh, Zengping Liu, Gavin Tan, Walter Hunziker, Veluchamy A Barathi, Jun Yi Ong, Daniel Soo Lin Wong, Graham E. Holder, Xianmin Zeng, Gopal Lingam, Bhav Harshad Parikh, Swathi Lingam, Wendy Wong, Queenie Shu Woon Tan, Binxia Yang, Xinyi Su, Kakkad Regha
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor precursors
Publikováno v:
Genes. 13:344
Inherited retinal diseases (IRDs) represent a genetically and clinically heterogenous group of diseases that can eventually lead to blindness. Advances in sequencing technologies have resulted in better molecular characterization and genotype–pheno
Autor:
Kara Grise, Ugur Kale, Debbie Goh, Nathan Calvert, Mete Akcaoglu, Leah Devine, Theresa Cullen
Publikováno v:
TechTrends. 62:574-584
Computational thinking is one of the skills critical for successfully solving problems posed in a technology driven and complex society. The limited opportunities in school settings to help students develop computational thinking skills underscores t