Abstract B44: ImmTAC molecules: Beyond HLA-A*02:01—the identification and isolation of dual-HLA-specific T cell receptors

Autor: Maria Busz, Linda Hibbert, Luke Williams, Elizabeth E. Evans, Karolina Lech, Joseph Dukes, Annelise Vuidepot, Vanessa L. Clark, Sarah K. Bailey, Alice Barkell, Bent K. Jakobsen, Kathy Hale, Michelle Teng, Debbie E. Wright, Alasdair Gunn

Publikováno v: Cancer Immunology Research. 8:B44-B44

ImmTAC (Immune mobilizing monoclonal TCRs against cancer) molecules are a new class of bi-specific biologic that combine a T-cell receptor (TCR)-targeting system with an anti-CD3 effector function to activate highly potent and specific T-cell respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e66605e7ed8d63d45c0d40fa19ee87a6
https://doi.org/10.1158/2326-6074.tumimm18-b44

Murid herpesvirus-4 lacking thymidine kinase reveals route-dependent requirements for host colonization

Autor: Debbie E. Wright, Philip G. Stevenson, Michael Gill, Christopher M. Smith, Janet S. May

Publikováno v: The Journal of General Virology

Gammaherpesviruses infect at least 90 % of the world's population. Infection control is difficult, in part because some fundamental features of host colonization remain unknown, for example whether normal latency establishment requires viral lytic fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d846dc351f0e7bd73a46fb5ef78a9592
http://europepmc.org/articles/PMC2885060

Erratum: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome

Autor: Alan Tracey, Lucy Barr, Karen Holt, Stephen J. Trevanion, Bob Plumb, Daniel Leongamornlert, Paul Wray, Carol Churcher, J. C. Davis, Ruth Gilderthorp, Christine Lloyd, Adrienne Hunt, Michelle Smith, Britt Kilian, Martina Konantz, Jeff Almeida-King, Richard M. Clark, Nick Barker, Kirsty Ambridge, Susan J. Clark, Karen Oliver, Glen Threadgold, Yong Gu, Jane E. Loveland, David Lloyd, Guy Griffiths, Ronald H.A. Plasterk, Karen McLaren, Sarah Pelan, Sarah Nichol, Kenric Leung, Rebecca Woodmansey, Sharmin Begum, Cigdem Eser, Sophie Palmer, Jacqueline Brown, Ian M Sealy, James Torrance, J Lovell, John E. Collins, Sara Widaa, A M Kimberley, A Tromans, Richard Pandian, Judith Konantz, Maria Geisler, Carlos Torroja, N Sycamore, Sancha Martin, Darren Barker, Amanda Rapp, Monte Westerfield, Silke Rudolph-Geiger, Zemin Ning, José Afonso Guerra-Assunção, Clare Riddle, Rebecca Glithero, Daniel P. Kelly, Nicholas Matthews, Pieter J. de Jong, Nigel P. Carter, Camille Berthelot, Fengtang Yang, A K Babbage, Graham Clark, Andrea Berger, Robert Andrews, C Griffiths, Jennifer Harrow, Gerd Jörg Rauch, Steve Searle, J. M. Wallis, Christa Lanz, Ruby Banerjee, William Chow, Jan Hinnerk Vogel, Matthieu Muffato, David Elliott, Mathias Teucke, Derek L. Stemple, Debbie E. Wright, Deepa Manthravadi, Gavin K. Laird, Sarah Sims, M Mashreghi-Mohammadi, David S. Saunders, Lena Karotki, P Garner, Paul Heath, Jane Rogers, Ines Gehring, J Garnett, Charles Lee, Philip Howden, John H. Postlethwait, Robert Geisler, Sarah Donaldson, Elizabeth Langley, Claire Raisen, Katherine Auger, Javier Herrero, Beiyuan Fu, Carol Scott, Zübeyde Ersan-Ürün, Mario Caccamo, Sean Humphray, Gary L A Barker, S. Whitehead, Darren Ware, Baoli Zhu, Jianxiang Chi, Jonathan Wood, Nigel Fosker, Sarah McGuire, Stephan C. Schuster, Chris Clee, Martina Oberländer, Daria Gordon, Clare Murnane, Romke Koch, Emma Gray, Beverley J. Mortimore, Harminder Sehra, Joanna Collins, Hugues Roest Crollius, Kirsten McLay, Kerstin Howe, Lauren Dyer, Christopher Stevens, Andrew D. Ellington, Kazutoyo Osoegawa, Stuart McLaren, Christopher N. Johnson, Giselle Kerry, Helen Beasley, Georgios Panagiotidis, Christiane Nüsslein Volhard, Tina Eyre, Horst Geiger, Jennifer Yen, Matthew Ellwood, Christine P. Bird, N Corby, Matthew Dunn, Darren Grafham, Günter Raddatz, Matthew Humphries, Anette Kirn, Yi Zhou, James D. Cooper, John Burton, Simon D. M. White, Anton J. Enright, Dave Willey, Tim Hubbard, Rebekah Hall, Michael Kay, Matthew D. Clark, Matthew Jones, Glenn Harden, C. D. Skuce, Lauren Robertson, Leonard I. Zon, Lucy Matthews, Jeffrey C. Barrett, Michael A. Quail, Emma J. Kenyon, Leonor T. Quintais, Benjamin Phillimore, S Hammond, Carl Henderson, Joanna Harley, Elliot Harrison, Cordelia Langford, Christopher M. Dooley, Sean Maguire

Publikováno v: Nature. 505:248-248

Nature 496, 498–503 (2013); doi:10.1038/nature12111 In this Letter, five authors were inadvertently omitted: Sharmin Begum and Christine Lloyd from the Wellcome Trust Sanger Institute, and Christa Lanz, Gunter Raddatz and Stephan C. Schuster from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4a7cb7d9ba994f1e878030cea016661
https://doi.org/10.1038/nature12813

An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules.

Autor: Harper, Jane¹, Adams, Katherine J.², Bossi, Giovanna¹, Wright, Debbie E.¹, Stacey, Andrea R.¹, Bedke, Nicole¹, Martinez-Hague, Ruth¹, Blat, Dan¹, Humbert, Laure¹, Buchanan, Hazel¹, Le Provost, Gabrielle S.¹, Donnellan, Zoe¹, Carreira, Ricardo J.¹, Paston, Samantha J.¹, Weigand, Luise U.¹, Canestraro, Martina¹, Sanderson, Joseph P.², Botta Gordon-Smith, Sophie¹, Lowe, Kate L.¹, Rygiel, Karolina A.¹

Publikováno v: PLoS ONE. 10/15/2018, Vol. 13 Issue 10, p1-19. 19p.