Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Debbie Deng"'
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain po
Externí odkaz:
https://doaj.org/article/d8b8fe0a0e6941c7a811944dff8fc5cc
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the features of this landscape remain poorly understood and cannot be revealed by human cancer genotyping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24eaf900600c609cefb81d012b1d1452
https://doi.org/10.1101/2022.10.24.511787
https://doi.org/10.1101/2022.10.24.511787
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v:
Cancer Research. 83:1172-1172
Cancer progression is a quintessential example of a walk on an adaptive fitness landscape, with tumor growth depending on the cooperation of multiple driver mutations. While sequencing of tens of thousands of clinical samples has revealed a vast set
Autor:
Alex Chenchik, Russell Darst, Donato Tedesco, Mikhail Makhanov, Lester Kobzik, Paul Diehl, Debbie Deng
Publikováno v:
Cancer Research. 80:5868-5868
Novel single-cell methods for profiling clonal composition and phenotypes of genetically modified cancer cells may improve understanding of tumorigenesis and guide the development of new anti-cancer drugs. To facilitate these studies, we developed a
Autor:
Paul Diehl, Donato Tedesco, Kyle Bonneau, Mikhail Makhanov, Debbie Deng, Peiqing Sun, Alex Chenchik
Publikováno v:
Cancer Research. 75:1721-1721
RNAi loss-of-function screening with pooled shRNA expression libraries has proven to be a useful tool to identify essential cancer genes and drug resistance mechanisms in numerous cell lines in vitro. The effects of knocking down large numbers of gen
Autor:
Alex Chenchik, Peiqing Sun, Donato Tedesco, Debbie Deng, Mikhail Makhanov, Paul Diehl, Kyle Bonneau
Publikováno v:
Cancer Research. 74:4266-4266
RNAi loss-of-function screening with pooled shRNA expression libraries has proven to be a useful tool to identify essential cancer genes and drug resistance mechanisms in numerous cell lines in vitro. The effects of knocking down large numbers of gen
Autor:
Karim Hyder, Debbie Deng, Alex Chenchik, Donato Tedesco, Costas G. Frangou, Mikhail Makhanov, Paul Diehl, Kyle Bonneau
Publikováno v:
Molecular Cancer Therapeutics. 12:A12-A12
One strategy to circumvent problems with conventional chemotherapy is to develop drugs against more specific cancer targets. Another is to use molecularly targeted agent (MTA) combinations to circumvent tumor resistance and increase the therapeutic i
Autor:
Paul Diehl, Pavel G. Komarov, Alex Chenchik, Dmitry Suchkov, Michael Yeluashvili, Mikhail Makhanov, Donato Tedesco, Andrei P. Komarov, Costa Frangou, Karim Hyder, Lilya Novototzkaja, Elena A. Komarova, Andrei V. Gudkov, Debbie Deng, Kyle Bonneau
Publikováno v:
Cancer Research. 73:3160-3160
We have developed an open-source RNAi genetic screening technology, funded in part by NIH grants and freely available to the scientific community. This platform can be used for functional discovery of drug targets associated with viability and regula
Autor:
Kyle Bonneau, Peiqing Sun, Donato Tedesco, Paul Diehl, Debbie Deng, Alex Chenchik, Mikhail Makhanov
Publikováno v:
Cancer Research. 73:3172-3172
We present results of clonal analysis studies aimed at characterizing the heterogeneity of in vivo cancer cell growth in xenograft models. Using a high-throughput sequencing method, we followed the fate of thousands of individually bar-coded cancer c
Autor:
Donato Tedesco, Kyle Bonneau, Mikhail Makhanov, Debbie Deng, Karim Hyder, Paul Diehl, Gus Frangou, Alex Chenchik
Publikováno v:
Cancer Research. 72:876-876
Background: One strategy to circumvent problems with conventional chemotherapy is to develop drugs against more specific cancer targets. Another is to use molecularly targeted agent (MTA) combinations to circumvent tumor resistance and increase the t