Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Debbie C. Mulhearn"'
Autor:
Alexander S. Mankin, Dorota Klepacki, Olga Krasnykh, Debbie C. Mulhearn, Scott G. Franzblau, Haripriya Ramu, Nora Vazquez-Laslop
Publikováno v:
Proceedings of the National Academy of Sciences. 108:10496-10501
Specific nascent peptides in the ribosome exit tunnel can elicit translation arrest. Such ribosome stalling is used for regulation of expression of some bacterial and eukaryotic genes. The stalling is sensitive to additional cellular cues, most commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3aec78ae92f4ec3d1dd012ea67580a
https://doi.org/10.1073/pnas.1103474108
https://doi.org/10.1073/pnas.1103474108
Autor:
Bellur S. Prabhakar, Valerie Grum-Tokars, Melissa M. Coughlin, Katrina Sleeman, Michael E. Johnson, Susan C. Baker, Andrew D. Mesecar, Gangli Gong, Debbie C. Mulhearn, Arun K. Ghosh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e42e979c1f9b7d8705283233cbc3fa5
https://doi.org/10.1016/j.bmcl.2008.08.082
https://doi.org/10.1016/j.bmcl.2008.08.082
Autor:
Subhasish Tapadar, Debbie C. Mulhearn, Gary M. Klein, Juan Chen, Yufeng Chen, Molly H. Bishop, Shuo Yang, Mahmood Ghassemi, Andrew D. Mesecar, Alan P. Kozikowski, Michael E. Johnson, James L. Cook, Suresh K. Tipparaju, Mary G. Johlfs, Bernard D. Santarsiero
Publikováno v:
ChemMedChem. 3:1250-1268
The problem of increasing bacterial resistance to the current generation of antibiotics is well documented. Known resistant pathogens such as methicillin-resistant Staphylococcus aureus are becoming more prevalent, while the potential exists for deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd5412eb54328b20e41d7e3363b52ff
https://doi.org/10.1002/cmdc.200800047
https://doi.org/10.1002/cmdc.200800047
Autor:
Mark M. Rasenick, Witchuda Saengsawang, Brian T. Layden, Robert J. Donati, Michael E. Johnson, Shuo Yang, Debbie C. Mulhearn
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783(6):964-973
A number of studies have demonstrated interplay between the cytoskeleton and G protein signaling. Many of these studies have determined a specific interaction between tubulin, the building block of microtubules, and G proteins. The alpha subunits of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5f79267e4ad4a8fd5dd901ba7d95ed
Publikováno v:
The Journal of Organic Chemistry. 67:8983-8990
B3LYP/aug-cc-pVDZ and MP2/6-31+G calculations of the reactions of HS(-) with small cyclic disulfides (dithiirane, 1,2-dithietane, 1,2-dithiolane, and 1,2-dithiane) were performed to determine the reaction mechanism. For the five- and six-membered rin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c12709493f98d9afe49b8db43c7c6f
https://doi.org/10.1021/jo026223k
https://doi.org/10.1021/jo026223k
Publikováno v:
Journal of Computational Chemistry. 18:198-210
All four possible Diels-Alder reactions between 2H-phosphole and phosphaethene were examined at various theoretical levels, including HF, MP4SDQ, CCSD(T), and CASSCF. MP2/6-31G* geometry optimizations could not be employed since the potential energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2b7c42556d9206d10615ee649464e0
https://doi.org/10.1002/(sici)1096-987x(19970130)18:2<198::aid-jcc5>3.0.co
https://doi.org/10.1002/(sici)1096-987x(19970130)18:2<198::aid-jcc5>3.0.co
Autor:
Hyun Lee, Debbie C. Mulhearn, Lena Truong, Jaime Torres, Joseph L. Gatuz, Anuradha Mittal, Kavankumar Patel, Michael E. Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry
We have used a combination of virtual screening (VS) and high-throughput screening (HTS) techniques to identify novel, non-peptidic small molecule inhibitors against human SARS-CoV 3CLpro. A structure-based VS approach integrating docking and pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaf004fd5919d655e4a3c97e1092983
https://pubmed.ncbi.nlm.nih.gov/24332657
https://pubmed.ncbi.nlm.nih.gov/24332657
Publikováno v:
The Journal of Physical Chemistry. 100:3535-3540
The thiolate−disulfide exchange reaction was studied at the HF/6-31+G*, MP2/6-31+G*, MP4SDTQ/6-31+G*//MP2/6-31+G*, and CCSD(T)/6-31+G*//MP2/6-31+G* levels for three identity reactions: R1S- + R2SSR3 → R1SSR2 + R3S-, where (1) R1 = R2 = R3 = H, (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb64e9026b6e9887db111bf2651cc71
https://doi.org/10.1021/jp953335p
https://doi.org/10.1021/jp953335p
Autor:
Debbie C. Mulhearn, Steven M. Bachrach
Publikováno v:
The Journal of Organic Chemistry. 60:7110-7116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872b781e1e786cbcfd37b79e8a3f80aa
https://doi.org/10.1021/jo00127a013
https://doi.org/10.1021/jo00127a013
Publikováno v:
The Journal of Organic Chemistry. 58:7883-7890
The Menschutkin-type alkylation of substituted N-methylanilines with methyl arene sulfonates is compared to the same reaction with substituted N-phenylhydroxylamines. The a-effects are small but measurable. The Hammett p parameters are not useful in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3d52b2f435108182897fe9085a3515
https://doi.org/10.1021/jo00079a038
https://doi.org/10.1021/jo00079a038