Prior exposure to inhaled allergen enhances anti-viral immunity and T cell priming by dendritic cells.

Autor: Debbie C P Lee, Neil Q Tay, Marini Thian, Nayana Prabhu, Kazuki Furuhashi, David M Kemeny

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190063 (2018)

Influenza and asthma are two of the major public health concerns in the world today. During the 2009 influenza pandemic asthma was found to be the commonest comorbid illness of patients admitted to hospital. Unexpectedly, it was also observed that as

Externí odkaz: https://doaj.org/article/f5fcf46f3c5847f0a1ecea640542dcad

Priming with high and low respiratory allergen dose induces differential CD4+ T helper type 2 cells and IgE/IgG1 antibody responses in mice

Autor: Yen Leong Chua, David M. Kemeny, Kenneth H. S. Wong, Ka H. Liong, Debbie C. P. Lee, Kazuki Furuhashi, Qian Zhou, Paul Edward Hutchinson, Guo H. Teo

Publikováno v: Immunology. 151:227-238

Sensitization of allergic patients normally takes place over several years and is the result of repeated exposure to low levels of allergen. Most mouse asthma models use a high dose of allergen administered over a short period. We have investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::897d93148b0117dd4b4c338ebefbf24f
https://doi.org/10.1111/imm.12726

Priming with high and low respiratory allergen dose induces differential CD4

Autor: Kazuki, Furuhashi, Yen L, Chua, Kenneth H S, Wong, Qian, Zhou, Debbie C P, Lee, Ka H, Liong, Guo H, Teo, Paul E, Hutchinson, David M, Kemeny

Publikováno v: Immunology. 151(2)

Sensitization of allergic patients normally takes place over several years and is the result of repeated exposure to low levels of allergen. Most mouse asthma models use a high dose of allergen administered over a short period. We have investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a115af1207c88e5680c23d9d3b53f585
https://pubmed.ncbi.nlm.nih.gov/28190273

Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life

Autor: Simone A. Walker, Debbie C. P. Lee, Lisa G. Gregory, James Buckley, Andrew Bush, Sejal Saglani, Adam J. Byrne, Clare M. Lloyd, Seif O. Shaheen

Publikováno v: Thorax

Background Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e227e90c284bc90e73576b65d3dee9d8
http://hdl.handle.net/10044/1/21296

CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection

Autor: Peter J. M. Openshaw, Jürgen Schwarze, Cecilia Johansson, James A. Harker, Sowsan F Atabani, John S. Tregoning, Debbie C. P. Lee

Publikováno v: Lee, D C P, Harker, J A E, Tregoning, J S, Atabani, S F, Johansson, C, Schwarze, J & Openshaw, P J M 2010, ' CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection ', Journal of Virology, vol. 84, no. 17, pp. 8790-8 . https://doi.org/10.1128/JVI.00796-10

Regulatory CD4 + T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention. Here we observed that following respiratory syncytial virus (RSV) infection, CD4 + Fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4798b4b710417b0936190a44aaa2fc
http://hdl.handle.net/10044/1/21948