SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children

Autor: Chintan K. Gandhi, Neal J. Thomas, Ye Meixia, Debbie Spear, Chenqi Fu, Shouhao Zhou, Rongling Wu, Garrett Keim, Nadir Yehya, Joanna Floros

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

We studied associations of persistent respiratory morbidity (PRM) at 6 and 12 months after acute respiratory failure (ARF) in previously healthy children with single-nucleotide polymorphisms (SNPs) of surfactant protein (SP) genes. Of the 250 enrolle

Externí odkaz: https://doaj.org/article/7d8a3a6955584acab6a4f9de4e9c15d9

Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial

Autor: Eliotte L. Hirshberg, Jamin L. Alexander, Lisa A. Asaro, Kerry Coughlin-Wells, Garry M. Steil, Debbie Spear, Cheryl Stone, Vinay M. Nadkarni, Michael S.D. Agus, Michael Agus, David Wypij, Lisa Asaro, Vinay Nadkarni, Vijay Srinivasan, Katherine Biagas, Peter M. Mourani, Ranjit Chima, Neal J. Thomas, Simon Li, Alan Pinto, Christopher Newth, Amanda Hassinger, Kris Bysani, Kyle J. Rehder, Edward Vincent Faustino, Sarah Kandil, Eliotte Hirshberg, Kupper Wintergerst, Adam Schwarz, Dayanand Bagdure, Lauren Marsillio, Natalie Cvijanovich, Nga Pham, Michael Quasney, Heidi Flori, Myke Federman, Sholeen Nett, Neethi Pinto, Shirley Viteri, James Schneider, Shivanand Medar, Anil Sapru, Patrick McQuillen, Christopher Babbitt, John C. Lin, Philippe Jouvet, Ofer Yanay, Christine Allen, Peter Luckett, James Fackler, Thomas Rozen

Publikováno v: Chest. 160:919-928

BACKGROUND The use of electronic clinical decision support (CDS) systems for pediatric critical care trials is rare. We sought to describe in detail the use of a CDS tool (Children's Hospital Euglycemia for Kids Spreadsheet [CHECKS]), for the managem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eacdb212b62832f6c548105ca607ba48
https://doi.org/10.1016/j.chest.2021.04.049

Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation

Autor: Zissis C. Chroneos, Margaret Mathewson, Daniel J. McKeone, Steven D. Hicks, E. Scott Halstead, Todd M. Umstead, Ming Wang, Debbie Spear, Priti G. Dalal, Neal J. Thomas

Publikováno v: Pediatr Crit Care Med

Objectives To identify and compare serum and lower respiratory tract fluid biomarkers of lung injury using well-characterized mouse models of lung injury. To explore the relationship between these preclinical biomarkers and clinical outcomes in a dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8268f5424a9c116739c82fd97c5f9446
https://pubmed.ncbi.nlm.nih.gov/33278219

Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States

Autor: Sapna R. Kudchadkar, Archana Nelliot, Ronke Awojoodu, Dhananjay Vaidya, Chani Traube, Tracie Walker, Dale M. Needham, Michael S. D. Agus, Kerry Coughlin-Wells, Christopher J. Babbitt, Sangita Basnet, Allison Spenner, Christine Bailey, Kristen N. Lee, Deanna Behrens, Ramona Donovan, Kristina A. Betters, Marguerite O. Canter, Meredith F. Bone, Sara VandenBranden, Gokul Kris Bysani, Maddie Chrisman, Ericka L. Fink, LeeAnn Christie, Jean Christopher, Christina Cifra, Weerapong Lilitwat, David S. Cooper, Alicia Rice, Allison S. Cowl, Jason W. Custer, Melissa G. Chung, Danielle Van Damme, Kristen A. Smith, Rebecca Dixon, Molly V. Dorfman, Ashley Mancini, Sharon P. Dial, Jane L. Di Gennaro, Leslie A. Dervan, Lesley Doughty, Laura Benken, Mark C. Dugan, Judith Ben Ari, Melanie Cooper Flaigle, Vianne Smith, Shira J. Gertz, Katherine Gregersen, Shamel A. Abd-Allah, Justin Hamrick, Katherine Irby, Jodi Herbsman, Yasir M. Al-Qaqaa, John Holcroft, Erin Hulfish, Kathleen Culver, Susan Hupp, Andrea DeMonbrun, Kelechi Iheagwara, Shelli Lavigne-Sims, Christine Joyce, Pradip Kamat, Cheryl Stone, Sameer S. Kamath, Melissa Harward, Priscilla Kaszubski, Joanne Daguanno, Robert P. Kavanagh, Debbie Spear, Yu Kawai, Karen Fryer, Bree Kramer, Erin M. Kreml, Brian T. Burrows, Andrew W. Kiragu, John Lane, Truc M. Le, Stacey R. Williams, John C. Lin, Amanda Florin, Peter M. Luckett, Tammy Robertson, Vanessa N. Madrigal, Ashleigh B. Harlow, Barry Markovitz, Fernando Beltramo, Michael C. McCrory, Robin L. McKinney, Maryam Y. Naim, Asha G. Nair, Ravi Thiagarajan, Shilpa Narayan, Kathleen Murkowski, Keshava Murthy Narayana Gowda, Jhoclay See, Pooja A. Nawathe, William E. Novotny, Cynthia Keel, Peter Oishi, Neelima Marupudi, Laura Ortmann, A. M. Iqbal O’Meara, Nikki Miller Ferguson, Megan E. Peters, Neethi Pinto, Allison Kniola, Courtney M. Rowan, Jill Mazurczyk, Shilpa Shah, Sage Lachman, Marcy N. Singleton, Sholeen T. Nett, Michael C. Spaeder, Jenna V. Zschaebitz, Thomas Spentzas, Sue S. Sreedhar, Katherine M. Steffen, Michelle Chen, Anne Stormorken, Allison Blatz, Sachin D. Tadphale, Robert C. Tasker, John F. Griffin, Tammy L. Uhl, Karen H. Walson, Cynthia Bates, Christopher M. Watson, Mary Lynn Sheram, Cydni N. Williams, Aileen Kirby, Michael Wolf, Kellet Lowry, Heather A. Wolfe, Andrew R. Yates, Brian Beckman

Publikováno v: Crit Care Med

With decreasing mortality in PICUs, a growing number of survivors experience long-lasting physical impairments. Early physical rehabilitation and mobilization during critical illness are safe and feasible, but little is known about the prevalence in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa3d6af989c3afa3d2e142170070297
https://europepmc.org/articles/PMC7539558/

Association of SNP–SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure

Autor: Joanna Floros, Susan L. DiAngelo, Chintan Gandhi, Chixiang Chen, Garrett Keim, Rongling Wu, Nithyananda Thorenoor, Lili Yang, Nadir Yehya, Neal J. Thomas, Debbie Spear

Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 4
Journal of Clinical Medicine, Vol 9, Iss 1183, p 1183 (2020)

The hallmarks of pediatric acute respiratory failure (ARF) are dysregulated inflammation and surfactant dysfunction. The objective is to study association of surfactant protein (SP) genes&rsquo
single nucleotide polymorphisms (SNPs) with ARF and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b251b307b78f80b4ae4a283d1dd9b43